Target Validation Information
Target ID T53748
Target Name Enoyl-ACP reductase
Target Type
Successful
Drug Potency against Target 2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol Drug Info IC50 = 440 nM [528892]
4-(2,4-dichloro-phenoxy)-biphenyl-3-ol Drug Info IC50 = 140 nM [528892]
BUTEIN Drug Info Ki = 14 nM [528645]
4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol Drug Info IC50 = 190 nM [529962]
2-(2,4-dichlorophenoxy)-5-methylphenol Drug Info IC50 = 200 nM [528892]
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol Drug Info IC50 = 290 nM [529962]
5-butyl-2-(2,4-dichlorophenoxy)phenol Drug Info IC50 = 480 nM [529962]
MORIN Drug Info IC50 = 5000 nM [528213]
FISETIN Drug Info IC50 = 1000 nM [528213]
OROIDIN Drug Info Ki = 800 nM [529012]
5-chloro-2-(2-chloro-4-hydroxyphenoxy)phenol Drug Info IC50 = 220 nM [527778]
3,7-dihydroxy-flavone Drug Info IC50 = 10000 nM [528213]
GALLOCATECHIN GALLATE Drug Info IC50 = 500 nM [528213]
ISORHAMNETIN Drug Info IC50 = 5000 nM [528213]
5-chloro-2-(2-chloro-4-nitrophenoxy)phenol Drug Info IC50 = 180 nM [527778]
(-)-CATECHINGALLATE Drug Info Ki = 40 nM [528213]
EPIGALOCATECHIN GALLATE Drug Info Ki = 8 nM [528645]
2-(2,4-dichlorophenoxy)-5-isobutylphenol Drug Info IC50 = 180 nM [529962]
2-(2,4-dichlorophenoxy)-5-ethylphenol Drug Info IC50 = 110 nM [528892]
4-(2,4-dichloro-phenoxy)-4'-fluoro-biphenyl-3-ol Drug Info IC50 = 38 nM [528892]
2-(2,4-dichlorophenoxy)-5-propylphenol Drug Info IC50 = 210 nM [528892]
2-(2,4-dichlorophenoxy)-5-isopentylphenol Drug Info IC50 = 120 nM [529962]
4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol Drug Info IC50 = 230 nM [529962]
2-(4-amino-2-chlorophenoxy)-5-chlorophenol Drug Info IC50 = 360 nM [527778]
4-(2,4-dichloro-phenoxy)-2'-methyl-biphenyl-3-ol Drug Info IC50 = 440 nM [528892]
5-benzyl-2-(2,4-dichlorophenoxy)phenol Drug Info IC50 = 71 nM [529962]
2-(2,4-dichlorophenoxy)-5-phenethylphenol Drug Info IC50 = 76 nM [529962]
4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile Drug Info IC50 = 49 nM [528892]
2-(4-chloro-2-hydroxyphenoxy)benzenaminium Drug Info IC50 = 7000 nM [529962]
3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzamide Drug Info IC50 = 120 nM [527778]
Triclosan Drug Info IC50 = 100 nM [552683]
References
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 528645J Med Chem. 2007 Feb 22;50(4):765-75. Epub 2007 Jan 31.Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 529012Bioorg Med Chem. 2007 Nov 1;15(21):6834-45. Epub 2007 Aug 22.Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
Ref 527778Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. Epub 2005 Sep 29.Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 527778Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. Epub 2005 Sep 29.Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528645J Med Chem. 2007 Feb 22;50(4):765-75. Epub 2007 Jan 31.Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 527778Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. Epub 2005 Sep 29.Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 528892J Biol Chem. 2007 Aug 31;282(35):25436-44. Epub 2007 Jun 13.X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
Ref 529962Eur J Med Chem. 2009 Jul;44(7):3009-19. Epub 2009 Jan 19.Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Ref 527778Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. Epub 2005 Sep 29.Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Ref 552683Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis. Curr Top Med Chem. 2007;7(5):489-98.

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