Target Information

Target General Infomation
Target ID
T00419
Former ID
TTDI02195
Target Name
Fast skeletal muscle troponin complex
Gene Name
TNNC2
Synonyms
Beta-TnTF; Fast skeletal muscle troponin T; TNNI2; TNNT3; TnTf; Troponin C, skeletal muscle; Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; Troponin T, fast skeletal muscle; fTnT; TNNC2
Target Type
Clinical Trial
Disease Muscle fatigue [ICD9: 780.7; ICD10: R53]
Muscular atrophy [ICD9: 728.2; ICD10: M62.5]
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
BioChemical Class
Troponin
UniProt ID
P02585
Sequence
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAII
EEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIF
RASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
Drugs and Mode of Action
Drug(s) CK-2017357 Drug Info Phase 2 Muscle fatigue [523056], [543035]
CK-2127107 Drug Info Phase 1 Muscular atrophy [549466]
Modulator CK-2017357 Drug Info [531804], [532793]
CK-2127107 Drug Info [531804]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
PathWhiz Pathway Muscle/Heart Contraction
Reactome Striated Muscle Contraction
WikiPathways Striated Muscle Contraction
Muscle contraction
References
Ref 523056ClinicalTrials.gov (NCT01131013) A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication. U.S. National Institutes of Health.
Ref 543035(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8280).
Ref 549466Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037810)
Ref 531804Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5.
Ref 532793Effect of tirasemtiv, a selective activator of the fast skeletal muscle troponin complex, in patients with peripheral artery disease. Vasc Med. 2014 May 28;19(4):297-306.

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