Target Information

Target General Infomation
Target ID
T10735
Former ID
TTDC00027
Target Name
Histidine decarboxylase
Gene Name
HDC
Synonyms
HDC
Target Type
Clinical Trial
Disease Pruritus [ICD9: 698; ICD10: L29]
Skin infections [ICD9: 680-709; ICD10: L00-L99]
Function
Catalyzes the biosynthesis of histamine from histidine.
BioChemical Class
Carbon-carbon lyase
Target Validation
T10735
UniProt ID
P19113
EC Number
EC 4.1.1.22
Sequence
MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGD
IERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVM
DWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESC
LNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVF
VCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFT
FNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSV
KLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLT
ENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCT
SQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGL
HLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPT
EASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQA
MV
Structure
4E1O
Drugs and Mode of Action
Drug(s) BF-Derm1 Drug Info Phase 2 Skin infections [547936]
ALPHA-FMH Drug Info Phase 1 Pruritus [468247]
Modulator ALPHA-FMH Drug Info [532504]
Inhibitor AMA Drug Info [543399]
BF-Derm1 Drug Info [550362]
Brocresine Drug Info [536583], [537766]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Histidine metabolism
Metabolic pathways
PANTHER Pathway Histamine synthesis
CCKR signaling map ST
PathWhiz Pathway Histidine Metabolism
WikiPathways Biogenic Amine Synthesis
Metabolism of amino acids and derivatives
References
Ref 468247(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5189).
Ref 547936Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020550)
Ref 532504Alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures. Mol Pharmacol. 1985 Aug;28(2):191-9.
Ref 536583Histamine in brain--its role in regulation of seizure susceptibility. Epilepsy Res. 1991 Nov-Dec;10(2-3):111-8.
Ref 537766Effects of brocresine (NSD-1055) and cycloheximide on amino acid decarboxylase activities in gastric mucosa of normal and vagally denervated rats. Br J Pharmacol. 1972 Dec;46(4):688-95.
Ref 543399(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1274).
Ref 550362Clinical pipeline report, company report or official report of Biofrontera (2009).

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