Target Information

Target General Infomation
Target ID
T19579
Former ID
TTDC00026
Target Name
Interleukin-2 receptor subunit beta
Gene Name
IL2RB
Synonyms
CD122; High affinity IL-2 receptor subunit beta; IL-2 receptor; P70-75; p75; IL2RB
Target Type
Clinical Trial
Disease Glioblastoma multiforme [ICD9: 191; ICD10: C71]
Head and neck cancer; Human immunodeficiency virus infection [ICD9:140-149, 140-229, 279.3; ICD10: C07-C14, C32-C33, B20-B26]
Unspecified [ICD code not available]
Function
Receptor for interleukin-2. Thisbeta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Target Validation
T19579
UniProt ID
P14784
Sequence
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQ
VHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMA
IQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEE
APLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
IPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDV
QKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFT
NQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCT
FPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVP
DLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQ
ELQGQDPTHLV
Drugs and Mode of Action
Drug(s) AFTVac Drug Info Phase 2 Glioblastoma multiforme [526997]
Leukocyte interleukin Drug Info Phase 1 Head and neck cancer; Human immunodeficiency virus infection [524718]
Modulator DAB-486-IL-2 Drug Info
Leukocyte interleukin Drug Info [533675]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Measles
HTLV-I infection
Transcriptional misregulation in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL12-mediated signaling events
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Downstream signaling in na&amp
#xef
ve CD8+ T cells
Reactome GPVI-mediated activation cascade
gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
Inflammatory Response Pathway
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 524718ClinicalTrials.gov (NCT02115919) Safety Study of Multikine in the Treatment of Perianal Warts. U.S. National Institutes of Health.
Ref 526997Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004 Mar 1;10(5):1574-9.
Ref 526997Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004 Mar 1;10(5):1574-9.
Ref 533675Leukocyte Interleukin, Inj. (LI) augmentation of natural killer cells and cytolytic T-lymphocytes. Immunopharmacol Immunotoxicol. 1995 May;17(2):247-64.

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