Target Information

Target General Infomation
Target ID
T25317
Former ID
TTDI02057
Target Name
Cholestenol delta-isomerase
Gene Name
EBP
Synonyms
3betahydroxysteroidDelta(8),Delta(7)isomerase; D8D7 sterol isomerase; Delta(8)Delta(7) sterol isomerase; Emopamilbinding protein; EBP
Target Type
Clinical Trial
Disease Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
BioChemical Class
Intramolecular oxidoreductases
UniProt ID
Q15125
EC Number
EC 5.3.3.5
Sequence
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
Drugs and Mode of Action
Drug(s) SR-31747 Drug Info Phase 2 Rheumatoid arthritis [534643]
Modulator SR-31747 Drug Info [534643]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Cholesterol biosynthesis III (via desmosterol)
Cholesterol biosynthesis I
Superpathway of cholesterol biosynthesis
KEGG Pathway Steroid biosynthesis
Metabolic pathways
References
Ref 534643Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.
Ref 534643Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.

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