Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T32240
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| Former ID |
TTDC00251
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| Target Name |
Interleukin-15
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| Gene Name |
IL15
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| Synonyms |
IL-15; IL15
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| Target Type |
Discontinued
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| Disease | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06] | ||||
| Function |
Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
|
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| BioChemical Class |
Cytokine: interleukin
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| Target Validation |
T32240
|
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| UniProt ID | |||||
| Sequence |
MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKI
EDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANN SLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Jak-STAT signaling pathway | |||||
| TNF signaling pathway | |||||
| Intestinal immune network for IgA production | |||||
| HTLV-I infection | |||||
| Herpes simplex infection | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| FSH Signaling Pathway | |||||
| Leptin Signaling Pathway | |||||
| PANTHER Pathway | Interleukin signaling pathway | ||||
| WikiPathways | Cytokines and Inflammatory Response | ||||
| References | |||||
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