Target Information

Target General Infomation
Target ID
T32855
Former ID
TTDR00478
Target Name
Neurotrophin-3
Gene Name
NTF3
Synonyms
HDNF; NGF-2; NT-3; Nerve growth factor 2; Neurotrophic factor; NTF3
Target Type
Discontinued
Disease Central nervous system disease [ICD10: G00-G99]
Constipation [ICD9: 564; ICD10: K59.0]
Function
Seems to promote the survival of visceral and proprioceptive sensory neurons.
BioChemical Class
NGF-beta family
UniProt ID
P20783
Sequence
MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQ
STLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLM
EDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIK
TGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWI
RIDTSCVCALSRKIGRT
Structure
1SG1; 1WWW; 2IFG; 4EDW; 4EDX; 1B8K; 1BND; 1NT3; 3BUK
Drugs and Mode of Action
Drug(s) NT-3 Drug Info Discontinued in Phase 2 Constipation [468135], [545887]
ReN-1826 Drug Info Terminated Central nervous system disease [547600]
Modulator NT-3 Drug Info [527621]
Inhibitor ReN-1826 Drug Info [528418]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Pathway Interaction Database SHP2 signaling
p75(NTR)-mediated signaling
Neurotrophic factor-mediated Trk receptor signaling
Trk receptor signaling mediated by the MAPK pathway
WikiPathways BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
References
Ref 468135(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5033).
Ref 545887Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005227)
Ref 547600Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017722)
Ref 527621NT-3. Takeda/Regeneron/Amgen. IDrugs. 2001 Jul;4(7):820-4.
Ref 528418Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J Allergy Clin Immunol. 2006 Sep;118(3):597-605. Epub 2006 Jul 3.

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