Target Information

Target General Infomation
Target ID
T55860
Former ID
TTDI02194
Target Name
OX40 ligand
Gene Name
TNFSF4
Synonyms
CD252; Glycoprotein Gp34; OX40L; TAX transcriptionally-activated glycoprotein 1; Tumor necrosis factor ligand superfamily member 4; TNFSF4
Target Type
Clinical Trial
Disease Asthma [ICD10: J45]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
BioChemical Class
Cytokine: tumor necrosis factor
UniProt ID
P23510
Sequence
MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQ
SIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQ
KDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEF
CVL
Drugs and Mode of Action
Drug(s) MEDI6383 Drug Info Phase 1 Solid tumours [549576]
RG7888 Drug Info Phase 1 Solid tumours [525142]
R4930 Drug Info Discontinued in Phase 2 Asthma [548706]
Modulator R4930 Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TSLP Signaling Pathway
Reactome TNFs bind their physiological receptors
WikiPathways Vitamin D Receptor Pathway
TSLP Signaling Pathway
References
Ref 525142ClinicalTrials.gov (NCT02410512) A Dose-Escalation Study of the Safety and Pharmacokinetics of MOXR0916 and MPDL3280A in Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
Ref 548706Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027884)
Ref 549576Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041453)
Ref 544456Anti-tumor efficacy and biomarker evaluation of agonistic anti-OX40 antibodies in preclinical models. J Immunother Cancer. 2014; 2(Suppl 3): P105.
Ref 549704J Clin Oncol 33, 2015 (suppl; abstr 3056).

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