Target Information

Target General Infomation
Target ID
T83192
Former ID
TTDR00032
Target Name
Ciliary neurotrophic factor
Gene Name
CNTF
Synonyms
CNTF
Target Type
Clinical Trial
Disease Huntington's disease [ICD9: 294.1, 333.4; ICD10: F02.2, G10]
Ovarian cancer [ICD9: 183; ICD10: C56]
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
BioChemical Class
Ciliary neurotrophic factor
UniProt ID
P26441
Sequence
MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVAS
TDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFA
YQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFIS
SHQTGIPARGSHYIANNKKM
Drugs and Mode of Action
Drug(s) CNTF, Syntex-Synergen, cell therapy Drug Info Phase 2 Huntington's disease [523794]
NT-501 CNTF Drug Info Phase 1/2 Ovarian cancer [523988]
Modulator CNTF, Syntex-Synergen, cell therapy Drug Info [534370], [534385]
NT-501 CNTF Drug Info [551424]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Differentiation Pathway
References
Ref 523794ClinicalTrials.gov (NCT01530659) Retinal Imaging of Subjects Implanted With Ciliary Neurotrophic Factor (CNTF)-Releasing Encapsulated Cell Implant for Early-stage Retinitis Pigmentosa. U.S. National Institutes of Health.
Ref 523988ClinicalTrials.gov (NCT01648452) CNTF Implants for CNGB3 Achromatopsia. U.S. National Institutes of Health.
Ref 534370Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature. 1997 Mar 27;386(6623):395-9.
Ref 534385Reliability of maximal voluntary isometric contraction testing in a multicenter study of patients with amyotrophic lateral sclerosis. Syntex/Synergen Neuroscience Joint Venture rhCNTF ALS Study Group. Muscle Nerve. 1997 Jun;20(6):691-5.
Ref 551424Clinical pipeline report, company report or official report of Neurotech.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.