Target Information

Target General Infomation
Target ID
T86115
Former ID
TTDC00328
Target Name
mRNA of ApoC-III
Gene Name
APOC3
Synonyms
mRNA of Apo-CIII; mRNA of ApoC-III; mRNA of Apolipoprotein C3; APOC3
Target Type
Clinical Trial
Disease Inflammation; High triglycerides; Atherosclerosis; Metabolic syndrome [ICD9: 277.7, 414.0, 440; ICD10: E88.81, I70]
Function
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
BioChemical Class
Apolipoprotein
UniProt ID
P02656
Sequence
MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQAR
GWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
Drugs and Mode of Action
Drug(s) ISIS-APOCIII Drug Info Phase 1 Inflammation; High triglycerides; Atherosclerosis; Metabolic syndrome [551052]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway PPAR signaling pathway
Reactome Chylomicron-mediated lipid transport
HDL-mediated lipid transport
Retinoid metabolism and transport
WikiPathways Statin Pathway
PPAR Alpha Pathway
Visual phototransduction
Lipid digestion, mobilization, and transport
References
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).

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