Target Information

Target General Infomation
Target ID
T92124
Former ID
TTDC00219
Target Name
Tumor necrosis factor receptor superfamily member 4
Gene Name
TNFRSF4
Synonyms
ACT35 antigen; CD134 antigen; Cell surface receptor OX40; OX40 antigen; OX40L receptor; TAX-transcriptionally activated glycoprotein 1 receptor; TNFRSF4
Target Type
Clinical Trial
Disease Prostate cancer [ICD9: 185; ICD10: C61]
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
BioChemical Class
Transmembrane protein
Target Validation
T92124
UniProt ID
P43489
Sequence
MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQ
NTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYK
PGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQ
GPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLL
RRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI
Structure
1D0A; 2HEV; 2HEY
Drugs and Mode of Action
Drug(s) Anti-OX40 mab Drug Info Phase 1 Prostate cancer [532531]
Modulator Anti-OX40 mab Drug Info [543513]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway IL2 Signaling Pathway
Wnt Signaling Pathway
Pathway Interaction Database Downstream signaling in na&amp
#xef
ve CD8+ T cells
Reactome TNFs bind their physiological receptors
References
Ref 532531OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 2013 Dec 15;73(24):7189-98.
Ref 543513(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1873).

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