Target Information

Target General Infomation
Target ID
T94482
Former ID
TTDR00855
Target Name
Interleukin-20
Gene Name
IL20
Synonyms
Four alpha helix cytokine ZCYTO10; IL-20; UNQ852/PRO1801; IL20
Target Type
Clinical Trial
Disease Psoriasis [ICD9: 696; ICD10: L40]
Function
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
BioChemical Class
Cytokine: interleukin
UniProt ID
Q9NYY1
Sequence
MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI
DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK
KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
Drugs and Mode of Action
Drug(s) NN-8226 Drug Info Phase 2 Psoriasis [524692]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
References
Ref 524692ClinicalTrials.gov (NCT02097264) A Trial Investigating the Mechanism of Action of NNC0109-0012 (Anti-IL-20 mAb) Through Synovial Biopsies in Subjects With Rheumatoid Arthritis and an Inadequate Response to Methotrexate. U.S. National Institutes of Health.
Ref 551834Handbook of Therapeutic Antibodies. 2014. 1. Page(995).

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