Target Information
Target General Infomation | |||||
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Target ID |
T86918
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Former ID |
TTDS00397
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Target Name |
Pancreatic alpha-amylase
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Gene Name |
AMY2A
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Synonyms |
1,4-alpha-D-glucan glucanohydrolase; PA; AMY2A
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Target Type |
Clinical Trial
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Disease | Cystic fibrosis [ICD9: 277; ICD10: E84] | ||||
Pancreatic disease [ICD10: K85-K86] | |||||
BioChemical Class |
Glycosylases
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UniProt ID | |||||
EC Number |
EC 3.2.1.1
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Sequence |
MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGL LDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAG SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG FVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP RQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQP FTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGI KIYVSDDGKAHFSISNSAEDPFIAIHAESKL |
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Drugs and Mode of Action | |||||
Inhibitor | 4,6-Dideoxy-4-Amino-Alpha-D-Glucose | Drug Info | [551393] | ||
5-Hydroxymethyl-Chonduritol | Drug Info | [551393] | |||
6-Deoxy-Alpha-D-Glucose | Drug Info | [551393] | |||
Acarbose Derived Hexasaccharide | Drug Info | [551393] | |||
Acarviostatin III03 | Drug Info | [536633] | |||
Acarviostatin IV03 | Drug Info | [536633] | |||
Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen | Drug Info | [536748] | |||
Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen | Drug Info | [536748] | |||
Beta-D-Glucose | Drug Info | [551393] | |||
Hydroxycitric acid | Drug Info | [536413] | |||
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam | Drug Info | [551391] | |||
Pyroglutamic Acid | Drug Info | [551393] | |||
Modulator | Liprotamase | Drug Info | [549848] | ||
Pancrecarb | Drug Info | [550604] | |||
References | |||||
Ref 536413 | Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82. Epub 2007 May 3. | ||||
Ref 536633 | Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92. Epub 2008 Jan 26. | ||||
Ref 536748 | Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30. Epub 2008 Jun 14. |
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