Target Information

Target General Infomation
Target ID
T95446
Former ID
TTDI01943
Target Name
Cytochrome P450 reductase
Gene Name
POR
Synonyms
CPR; NADPHcytochrome P450 reductase; P450R; POR
Target Type
Discontinued
Disease Breast cancer [ICD9: 174, 175; ICD10: C50]
Dermatitis [ICD9: 692.9; ICD10: L20-L30]
Pruritus [ICD9: 698; ICD10: L29]
Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
BioChemical Class
Oxidoreductases acting on NADH or NADPH
UniProt ID
P16435
EC Number
EC 1.6.2.4
Sequence
MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTL
TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLA
DLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEH
FNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEES
SIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHL
MHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHP
FPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWV
VEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYET
KAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPF
IGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQS
HKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVD
YIKKLMTKGRYSLDVWS
Drugs and Mode of Action
Drug(s) Encapsulated cells Drug Info Discontinued in Phase 2 Breast cancer [546933]
DuP-630 Drug Info Terminated Dermatitis [545582]
DuP-983 Drug Info Terminated Pruritus [545462]
Modulator DuP-630 Drug Info [550870]
DuP-983 Drug Info [550870]
Encapsulated cells Drug Info [527680]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Superpathway of tryptophan utilization
Superpathway of melatonin degradation
Melatonin degradation I
Vitamin D&lt
sub&gt
3&lt
/sub&gt
biosynthesis
Bile acid biosynthesis, neutral pathway
WikiPathways Oxidation by Cytochrome P450
References
Ref 545462Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003352)
Ref 545582Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003777)
Ref 546933Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011277)
Ref 527680Peritoneal cancer treatment with CYP2B1 transfected, microencapsulated cells and ifosfamide. Cancer Gene Ther. 2006 Jan 1;13(1):65-73.
Ref 550870CN patent application no. 1096855, Composition produced by treatment and induction of nitrogen mono oxide synthase expressed matter, and use thereof.

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