Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00WMV
|
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| Former ID |
DIB021111
|
||||
| Drug Name |
UCL1684
|
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| Synonyms |
UCL-1684
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C34H30N4+2
|
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| InChI |
InChI=1S/C34H28N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20H,21-24H2/p+2
|
||||
| InChIKey |
HZWVJPDDZQOYGA-UHFFFAOYSA-P
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | KCa2.1 | Target Info | Blocker (channel blocker) | [2] | |
| KCa2.2 | Target Info | Blocker (channel blocker) | [3] | ||
| KCa2.3 | Target Info | Blocker (channel blocker) | [4] | ||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2320). | ||||
| REF 2 | Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. | ||||
| REF 3 | Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. | ||||
| REF 4 | SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34. | ||||
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