Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T11911
|
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| Former ID |
TTDI03307
|
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| Target Name |
KCa2.1
|
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| Gene Name |
KCNN1
|
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| Synonyms |
KCNN1
|
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| Target Type |
Clinical Trial
|
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| Disease | Myeloneuropathy [ICD10: G04.1] | ||||
| UniProt ID | |||||
| Sequence |
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS DCG |
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| Drugs and Mode of Action | |||||
| Drug(s) | dequalinium | Drug Info | Clinical trial | Myeloneuropathy | [1] |
| Blocker (channel blocker) | apamin | Drug Info | [2] | ||
| dequalinium | Drug Info | [2] | |||
| tetraethylammonium | Drug Info | [3] | |||
| UCL1684 | Drug Info | [3] | |||
| UCL1848 | Drug Info | [4] | |||
| Activator | EBIO | Drug Info | [3] | ||
| References | |||||
| REF 1 | Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83. | ||||
| REF 2 | Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. | ||||
| REF 3 | Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. | ||||
| REF 4 | The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30. | ||||
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