Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F4NS
|
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| Former ID |
DNC004616
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| Drug Name |
Mozavaptan
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| Drug Type |
Small molecular drug
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| Indication | Hyponatraemia [ICD10:E87.1] | Approved | [1], [2], [3] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C27H29N3O2
|
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| InChI |
InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
|
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| InChIKey |
WRNXUQJJCIZICJ-UHFFFAOYSA-N
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| CAS Number |
CAS 137975-06-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7980203, 10238465, 14929794, 29300265, 49876628, 50784549, 57339461, 85210057, 85856507, 92251402, 92720235, 103283744, 103938054, 104408167, 118843944, 125340574, 126522418, 126584454, 126620153, 126667663, 129623867, 131298331, 134341821, 135075013, 135650774, 137249480, 142385824, 152035180, 162009841, 162011504, 164826782, 170466304, 172914187, 174527391, 179149887, 206246079, 211535800, 223434818, 223658567, 225355504, 227838631, 241033722, 242059895, 252215844, 252472557
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| Target and Pathway | |||||
| Target(s) | Vasopressin V1b receptor | Target Info | Inhibitor | [4] | |
| Vasopressin V2 receptor | Target Info | Inhibitor | [4] | ||
| Vasopressin V1a receptor | Target Info | Inhibitor | [4] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contractionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Pathway Interaction Database | Arf6 trafficking events | ||||
| PathWhiz Pathway | Vasopressin Regulation of Water Homeostasis | ||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors | |||||
| G alpha (s) signalling events | |||||
| Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors | |||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| Regulation of Water Balance by Renal Aquaporins | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2197). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001739) | ||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 4 | J Med Chem. 1981 May;24(5):496-9.New analgesic drugs derived from phencyclidine. | ||||
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