| Drug General Information |
| Drug ID |
D0W3IQ
|
| Former ID |
DNC013159
|
| Drug Name |
D[Val4]AVP
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C46H65N13O11S2
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Vasopressin V2 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Oxytocin receptor |
Target Info |
Inhibitor |
[1]
|
| Vasopressin V1b receptor |
Target Info |
Inhibitor |
[1]
|
| Vasopressin V1a receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
|
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Oxytocin signaling pathwayhsa04020:Calcium signaling pathway
|
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Vascular smooth muscle contractionhsa04020:Calcium signaling pathway
|
|
Vascular smooth muscle contraction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
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PANTHER Pathway
|
Oxytocin receptor mediated signaling pathway
|
|
Pathway Interaction Database
|
Arf6 trafficking events
|
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PathWhiz Pathway
|
Vasopressin Regulation of Water Homeostasis
|
|
Reactome
|
Vasopressin-like receptors
|
|
G alpha (s) signalling events
|
|
Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors
|
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G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
|
|
G alpha (q) signalling events
|
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WikiPathways
|
GPCRs, Class A Rhodopsin-like
|
|
Regulation of Water Balance by Renal Aquaporins
|
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
|
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Myometrial Relaxation and Contraction Pathways
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Oxytocin signaling
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR downstream signaling
|
| References |
| REF 1 | J Med Chem. 2007 Feb 22;50(4):835-47.Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. |
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