Target Information
Target General Infomation | |||||
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Target ID |
T85616
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Former ID |
TTDC00075
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Target Name |
Thioredoxin
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Gene Name |
TXN
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Synonyms |
ADF; ATL-derived factor; SASP; Surface associated sulphydryl protein; TXN
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Target Type |
Clinical Trial
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
Function |
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
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BioChemical Class |
Thioredoxin
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Target Validation |
T85616
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UniProt ID | |||||
Sequence |
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV |
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Drugs and Mode of Action | |||||
Drug(s) | PX-12 | Drug Info | Phase 2 | Cancer | [1] |
Inhibitor | Acetate Ion | Drug Info | [2] | ||
Cacodylate Ion | Drug Info | [2] | |||
PX-12 | Drug Info | [3], [4], [5] | |||
Pathways | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
RANKL Signaling Pathway | |||||
PANTHER Pathway | Hypoxia response via HIF activation | ||||
Oxidative stress response | |||||
Pathway Interaction Database | p38 MAPK signaling pathway | ||||
Signaling events mediated by PTP1B | |||||
TNF receptor signaling pathway | |||||
PathWhiz Pathway | Purine Metabolism | ||||
Reactome | Oxidative Stress Induced Senescence | ||||
Detoxification of Reactive Oxygen Species | |||||
TP53 Regulates Metabolic Genes | |||||
The NLRP3 inflammasome | |||||
WikiPathways | NRF2 pathway | ||||
Nuclear Receptors Meta-Pathway | |||||
Detoxification of Reactive Oxygen Species | |||||
Human Complement System | |||||
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||||
TNF alpha Signaling Pathway | |||||
Metabolism of nucleotides | |||||
Selenium Micronutrient Network | |||||
References | |||||
REF 1 | The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. J Lab Clin Med. 2006 Feb;147(2):83-90. | ||||
REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
REF 3 | A Phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2109-14. | ||||
REF 4 | Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jun;29(5):359-73. | ||||
REF 5 | 2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Mol Cancer Ther. 2008 Jan;7(1):143-51. |
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