Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T46465
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Former ID |
TTDR00106
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Target Name |
Plasmepsin 2
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Synonyms |
Aspartic hemoglobinase II; PFAPD; Plasmepsin II
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Target Type |
Discontinued
|
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Disease | Malaria [ICD10: B54] | ||||
BioChemical Class |
Peptidase
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Target Validation |
T46465
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UniProt ID | |||||
EC Number |
EC 3.4.23.39
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Sequence |
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL |
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Drugs and Mode of Action | |||||
Inhibitor | E-64 | Drug Info | [538124] | ||
KNI-10006 | Drug Info | [531036] | |||
KNI-10033 | Drug Info | [528767] | |||
KNI-10061 | Drug Info | [528767] | |||
KNI-10062 | Drug Info | [528767] | |||
KNI-10074 | Drug Info | [529771] | |||
KNI-10079 | Drug Info | [529771] | |||
KNI-10080 | Drug Info | [529771] | |||
KNI-10081 | Drug Info | [529771] | |||
KNI-10087 | Drug Info | [529771] | |||
KNI-10088 | Drug Info | [529771] | |||
KNI-10092 | Drug Info | [529771] | |||
KNI-10093 | Drug Info | [529771] | |||
KNI-10094 | Drug Info | [529771] | |||
KNI-10095 | Drug Info | [529771] | |||
KNI-10106 | Drug Info | [529771] | |||
KNI-10113 | Drug Info | [529771] | |||
KNI-10124 | Drug Info | [529771] | |||
KNI-10125 | Drug Info | [529771] | |||
KNI-10152 | Drug Info | [529771] | |||
KNI-10155 | Drug Info | [529771] | |||
KNI-10216 | Drug Info | [529771] | |||
KNI-10217 | Drug Info | [529771] | |||
KNI-10232 | Drug Info | [528767] | |||
KNI-10255 | Drug Info | [529771] | |||
KNI-10256 | Drug Info | [529771] | |||
KNI-10260 | Drug Info | [529771] | |||
KNI-10265 | Drug Info | [529771] | |||
KNI-10266 | Drug Info | [529771] | |||
KNI-10282 | Drug Info | [529771] | |||
KNI-10283 | Drug Info | [529771] | |||
KNI-10313 | Drug Info | [528767] | |||
KNI-10314 | Drug Info | [528767] | |||
KNI-10315 | Drug Info | [528767] | |||
KNI-10316 | Drug Info | [528767] | |||
KNI-10332 | Drug Info | [528767] | |||
KNI-10341 | Drug Info | [528767] | |||
KNI-10342 | Drug Info | [528767] | |||
KNI-10368 | Drug Info | [528767] | |||
KNI-10369 | Drug Info | [529771] | |||
KNI-10372 | Drug Info | [528767] | |||
KNI-10526 | Drug Info | [529771] | |||
KNI-10527 | Drug Info | [529771] | |||
KNI-10529 | Drug Info | [529771] | |||
KNI-10538 | Drug Info | [531036] | |||
KNI-10539 | Drug Info | [529771] | |||
KNI-10541 | Drug Info | [529771] | |||
KNI-10737 | Drug Info | [531036] | |||
KNI-10740 | Drug Info | [531036] | |||
KNI-10741 | Drug Info | [531036] | |||
KNI-10742 | Drug Info | [531036] | |||
KNI-10743 | Drug Info | [531036] | |||
KNI-10758 | Drug Info | [531036] | |||
KNI-10759 | Drug Info | [531036] | |||
KNI-10760 | Drug Info | [531036] | |||
KNI-10761 | Drug Info | [531036] | |||
KNI-10762 | Drug Info | [531036] | |||
KNI-10763 | Drug Info | [531036] | |||
KNI-1293 | Drug Info | [529771] | |||
KNI-227 | Drug Info | [528767] | |||
KNI-727 | Drug Info | [535366] | |||
Leupeptin | Drug Info | [536365] | |||
N-(R-Carboxy-Ethyl)-Alpha-(S)-(2-Phenylethyl) | Drug Info | [551393] | |||
Pepstatin | Drug Info | [536365] | |||
PS-154636-1 | Drug Info | [534798] | |||
PS-222036 | Drug Info | [534798] | |||
PS-444035 | Drug Info | [534798] | |||
PS-662477 | Drug Info | [534798] | |||
PS-725074 | Drug Info | [534798] | |||
PS-777621 | Drug Info | [528560] | |||
References | |||||
Ref 528560 | J Med Chem. 2006 Dec 14;49(25):7440-9.High antiplasmodial activity of novel plasmepsins I and II inhibitors. | ||||
Ref 528767 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. Epub 2007 Mar 21.Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. | ||||
Ref 529771 | Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. Epub 2008 Oct 10.Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. | ||||
Ref 531036 | Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. Epub 2010 Jun 25.Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. | ||||
Ref 534798 | Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20.Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. | ||||
Ref 535366 | Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target. Biochemistry. 2002 Feb 19;41(7):2273-80. | ||||
Ref 536365 | Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6. |
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