Drug General Information
Drug ID
D0R2VH
Former ID
DIB018571
Drug Name
2-oleoyl-LPA
Synonyms
2-acyl-1LPA; 2Acyl-LPA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539953]
Structure
Download
2D MOL
Formula
C21H41O7P
InChI
InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)28-20(18-22)19-27-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
InChIKey
ZOOLJLSXNRZLDH-KTKRTIGZSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Lysophosphatidic acid receptor Edg-2 Target Info Agonist [525840]
Lysophosphatidate-3 receptor Target Info Agonist [525840]
LPA2 receptor Target Info Agonist [525840]
G protein-coupled receptor 35 Target Info Agonist [530825]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Gap junction
Pathways in cancerhsa04015:Rap1 signaling pathway
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-416476:G alpha (q) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Myometrial Relaxation and Contraction Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
References
Ref 539953(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2936).
Ref 525840Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett. 2000 Jul 28;478(1-2):159-65.
Ref 530825GPR35 is a novel lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2010 Apr 30;395(2):232-7.

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