Drug Information

Drug General Information
Drug ID
D0N1HE
Former ID
DIB021112
Drug Name
UCL1848
Synonyms
UCL-1848
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539468]
Structure
Download
2D MOL
Formula
C28H34N4+2
InChI
InChI=1S/C28H32N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22H,1-2,7-10,17-20H2/p+2
InChIKey
IOXVWOJJNCBJBX-UHFFFAOYSA-P
PubChem Compound ID
9811445
PubChem Substance ID
44847429, 56239371, 78806371, 103990335, 104037955, 135651296, 174489640, 242097400
Target and Pathway
Target(s) KCa2.1 Target Info Blocker (channel blocker) [525697]
KCa2.3 Target Info Blocker (channel blocker) [526131]
KCa2.2 Target Info Blocker (channel blocker) [526016]
References
Ref 539468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2321).
Ref 525697The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30.
Ref 526016Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13;276(15):12249-56. Epub 2001 Jan 22.
Ref 526131SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34.

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