Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 7alpha-[(4R,8R)-4,8,12-trimethyltridecyl]estra-1,3,5-trien-3,17beta-diol | Drug Info |
| MMP13 --- MMP1 | (S)-N-hydroxy-4-(4-(7-hydroxyhept-2-ynyloxy)phenylsulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid benzhydryl-amide | Drug Info |
| Erbeta --- ER | 6-(4-Hydroxy-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-naphthalen-2-ol; hydrochloride | Drug Info |
| MMP13 --- MMP1 | 4-benzylbenzyl(2-(cyclobutylmethyl)-3-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-oxopropyl)phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N,6-triethyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide] | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(3-hydroxy-phenyl)-3,4-dihydro-2H-quinolin-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-1-[4-(5-fluoro-2-methyl-benzyloxy)-benzenesulfonyl]-3-methyl-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (2-amino-phenyl)-amide | Drug Info |
| Erbeta --- ER | (S)-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(3-methylpyrrolidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzenesulfonyl]-5-hydroxy-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 7-Chloro-9,10-dihydro-phenanthrene-2-carboxylic acid | Drug Info |
| Erbeta --- ER | [5-Hydroxy-2-(4-hydroxy-phenyl)-naphtho[2,1-b]thiophen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | N-Hydroxy-2-(4-methoxy-benzenesulfonylamino)-2-methyl-propionamide | Drug Info |
| ABL --- Src | 4-(4-Chloro-2-fluoro-5-methoxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | SID24807318 | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(3-[1,2,3]triazol-1-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2-methylphenyl)-5,7-dihydroxy-4(3H)-quinazolinone | Drug Info |
| MMP13 --- MMP9 | N-hydroxy-2-(4-methoxyphenylsulfonyl)-2-propylpentanamide | Drug Info |
| PDGFR --- Src | 8-Methyl-2-(pyridin-4-ylamino)-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| Erbeta --- ER | CHEMBL2135534 | Drug Info |
| MMP2 --- HER2 | (1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)-5,7-dimethylbenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MMP2 --- MMP1 | N-Hydroxy-N-[1-(4-thiophen-2-yl-phenoxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID534102 | Drug Info |
| Erbeta --- mRNA of AR | SID4243681 | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-(4-phenyl-piperazin-1-yl)-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL254192 | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-methoxy-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829250 | Drug Info |
| Ftase --- FPTase | 4-(1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid 3-cyclohexyl-1-thiazol-5-yl-propyl ester | Drug Info |
| MMP2 --- MMP13 | N-benzyl-1-(4-(1-cyclopropyl-4-(hydroxycarbamoyl)piperidin-4-ylsulfonyl)phenyl)-N-methylpiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(trifluoromethyl)-9H-pyrido[3,4-b]indole | Drug Info |
| Ftase --- FPTase | 3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl-benzamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-2-(tetrahydro-2H-pyran-4-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-chlorophenyl)-N,N,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(5-((R)-2-amino-3-mercaptopropylamino)biphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2,5-dimethoxyphenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-bromo-4-(3-hydroxyphenyl)-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(3,4-dimethylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-ethyl-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(4'-Bromo-biphenyl-4-yl)-2-butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-3-amino-1-(4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-2,2-dimethylpropan-1-one | Drug Info |
| Ftase --- FPTase | 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| MMP2 --- MMP3 | 2-{4-[3'-(2-dimethylamino-ethoxy)-2-methyl-biphenyl-4-yl]-piperidine-1-sulfonyl}-N-hydroxy-2-methyl-propionamide | Drug Info |
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