Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- CDK2 | 1-[4-(2-Hydroxy-ethyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-6,7-dihydro-2H-pyrano[3,4-c]pyrrol-4-one | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic 28 (FTI-2347) | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 1-(3-fluoro-4-(2-(pyrimidin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| Ftase --- FPTase | Chaetomellic acid B | Drug Info |
| MMP3 --- MMP8 | 2-(5-Pyridin-2-yl-thiophen-2-ylmethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylcarbamoyl)-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(2-Pyridin-4-yl-ethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N1-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-methyl-N3-phenylmalonamide | Drug Info |
| Ftase --- FPTase | 6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one | Drug Info |
| MMP9 --- MMP14 | N-{(S)-1-[(R)-2-(4-Benzyloxy-phenyl)-1-dimethylcarbamoyl-ethylcarbamoyl]-2-phenyl-ethyl}-N'-hydroxy-oxalamide | Drug Info |
| VEGFR2 --- CSrc | CHEMBL383593 | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(1-oxy-pyridine-3-carbonyl)-piperidin-4-yl]-ethanone | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-chlorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | isobutyl4-(7-amino-3-(3-(4-(2-aminoacetyl)piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamate | Drug Info |
| Ftase --- FPTase | Isobutyric acid 2-((10R,13S)-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester | Drug Info |
| mTOR --- DNPK1 | CHEMBL179242 | Drug Info |
| VEGFR2 --- CSrc | 4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol | Drug Info |
| Ftase --- FPTase | (+/-)4-{2-[4-(9-bromo-4-chloro-1-methyl-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yliden)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(3-(dimethylamino)propyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | N-1,3-benzodioxol-4-yl-7-(3-pyrrolidin-1-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)furan-2-carboxamide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(dimethylamino)phenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | 2-Methyl-5-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol | Drug Info |
| Ftase --- FPTase | [4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-imidazol-1-yl-methanone | Drug Info |
| mTOR --- PI3K gamma | 4-(6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- FGFR1 | N-(4-Benzyloxy-butyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| Ftase --- FPTase | NA | Drug Info |
| mTOR --- PI3K gamma | (3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)methanol | Drug Info |
| VEGFR2 --- TEK | (E/Z)-4-(2-(6-phenyl-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 2-Benzyloxy-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| NET --- SERT | 1-(2-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-imidazolidin-2-one | Drug Info |
| VEGFR2 --- TEK | 3-ethyl-19-methyl-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-iodo-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NET --- SERT | 2-(1-Ethyl-4-methyl-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| VEGFR2 --- TEK | rac-9-cyclopentyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-3-yl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-4-(4-Acetylpiperazin-1-yl)but-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(2-methylpropyl)-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-morpholinoethoxy)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 3-(2-(6-aminopyridin-3-yl)ethynyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | N-Isobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | SID124349952 | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-{(1E)-4-[4-(methylsulfonyl)piperazin-1-yl]but-1-en-1-yl}nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-ethylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4-carboxylic acid | Drug Info |
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