| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T97713 | ||||
| Target Name | Inosine-5'-monophosphate dehydrogenase 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Mycophenolic hydroxamic acid | Drug Info | IC50 = 350 nM | [1] | |
| Mycophenolic bis(sulfonamide) | Drug Info | Ki = 18200 nM | [2] | ||
| Tiazofurin adenine dinucleotide | Drug Info | Ki = 100 nM | [3] | ||
| Azathioprine | Drug Info | IC50 = 500 nM | [4] | ||
| References | |||||
| REF 1 | Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. Epub 2010 Sep 18.Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells amongthe mycophenolic acid derivatives. | ||||
| REF 2 | Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. Epub 2008 Jun 10.Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. | ||||
| REF 3 | J Med Chem. 2007 Dec 27;50(26):6685-91. Epub 2007 Nov 27.Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. | ||||
| REF 4 | AMPA receptor antagonists as potential anticonvulsant drugs. Curr Top Med Chem. 2005;5(1):31-42. | ||||
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