Target Validation Information
Target ID T14912
Target Name Induced myeloid leukemia cell differentiation protein Mcl-1
Target Type
Clinical Trial
Drug Potency against Target TW-37 Drug Info IC50 = 1030 nM [528469]
NSC-180246 Drug Info IC50 = 3944.08 nM [531262]
MORIN Drug Info IC50 = 2988.26 nM [531262]
GNF-PF-5134 Drug Info IC50 = 9187.06 nM [531262]
NSC-66209 Drug Info IC50 = 5376.77 nM [531262]
SULFURETIN Drug Info IC50 = 1534.63 nM [531262]
CEPHALOCHROMIN Drug Info IC50 = 1491.9 nM [531262]
ROSMARINIC ACID Drug Info IC50 = 2025.72 nM [531262]
AMENTOFLAVONE Drug Info IC50 = 1634.07 nM [531262]
GNF-PF-1591 Drug Info IC50 = 19733.2 nM [531262]
BITHIONOL Drug Info IC50 = 1898.89 nM [531262]
QEDIIRNIARHLAQVGDSMDR Drug Info IC50 = 52 nM [528469]
GNF-PF-3955 Drug Info IC50 = 3567.91 nM [531262]
ALTENUSIN Drug Info IC50 = 4147.65 nM [531262]
The Effect of Target Knockout, Knockdown or Genetic Variations Administration of ABT-737 to Mcl-1 knockout mice induced severe liver apoptosis, suggesting that t uMor-specific inhibition of Mcl-1 is required for therapeutic purposes [528469]
References
Ref 528469J Med Chem. 2006 Oct 19;49(21):6139-42.Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 528469J Med Chem. 2006 Oct 19;49(21):6139-42.Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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