Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03TDN
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| Former ID |
DIB018510
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| Drug Name |
1-naphthylpiperazine
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| Synonyms |
1-(1-Naphthyl)piperazine; 1-Naphthylpiperazine; 57536-86-4; 1-(naphthalen-1-yl)piperazine; 1-naphthalen-1-ylpiperazine; 1-Naphthalen-1-yl-piperazine; CHEMBL277120; Piperazine, 1-(1-naphthalenyl)-; Piperazine,1-(1-naphthalenyl)-; 4-(naphth-1-yl)piperazine; Naphthylpiperazine; GTPL3; Lopac-S-003; AC1Q1INU; N-(1-naphthyl)piperazine; 4-(1-naphthyl)piperazine; Biomol-NT_000100; N-(1- naphthyl)piperazine; N-(1-naphthyl)-piperazine; N-(1-naphthyl) piperazine; AC1L1B9K; 4-(1-naphthyl) piperazine; 1-(naphth-1-yl)piperazine; Oprea1_621306; 1-NP
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C14H16N2
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| Canonical SMILES |
C1CN(CCN1)C2=CC=CC3=CC=CC=C32
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| InChI |
1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
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| InChIKey |
VNICFCQJUVFULD-UHFFFAOYSA-N
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| CAS Number |
CAS 57536-86-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5195350, 8151097, 11111754, 15195770, 24439684, 26755723, 36664359, 47216961, 47515510, 47515511, 47885589, 48185169, 48334697, 50111260, 57320874, 77298398, 85209805, 85788302, 90341223, 103086821, 103154609, 103183489, 103904019, 103920682, 104297461, 108138382, 117358857, 124750299, 124881352, 124881353, 125540784, 129499449, 129614306, 134224151, 134340784, 135081755, 135649669, 135693357, 137011689, 140305635, 162222858, 162875336, 165815772, 179235687, 184551215, 223749344, 226590908, 248606579
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| ChEBI ID |
CHEBI:108599
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3). | |||
| REF 2 | Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. | |||
| REF 3 | 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. | |||
| REF 4 | 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. | |||
| REF 5 | Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. | |||
| REF 6 | Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. | |||
| REF 7 | Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. | |||
| REF 8 | Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76. | |||
| REF 9 | Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. | |||
| REF 10 | Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. | |||
| REF 11 | 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11. | |||
| REF 12 | Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. | |||
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