Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09OYA
|
|||
| Former ID |
DIB018821
|
|||
| Drug Name |
alpha-methyl-5-HT
|
|||
| Synonyms |
alpha-Me-5-HT; alpha-methylserotonin
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C11H14N2O
|
|||
| Canonical SMILES |
CC(CC1=CNC2=C1C=C(C=C2)O)N
|
|||
| InChI |
1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3
|
|||
| InChIKey |
LYPCGXKCQDYTFV-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 304-52-9
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
7402877, 7978666, 8151425, 14797321, 26751772, 29221287, 46530747, 47217002, 47365424, 47440491, 47515544, 47662519, 47885616, 48035362, 50104459, 57321141, 77795200, 85209844, 90341561, 103182897, 103926819, 104299625, 124750028, 124880621, 124880622, 128560036, 134341330, 135649924, 137005041, 140189870, 143298771, 163240508, 164780431, 170539560, 179236039, 216242915, 225119218, 226725872
|
|||
| ChEBI ID |
CHEBI:48295
|
|||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 152). | |||
| REF 2 | Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. | |||
| REF 3 | Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. | |||
| REF 4 | Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. | |||
| REF 5 | Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. Mol Pharmacol. 2000 Nov;58(5):877-86. | |||
| REF 6 | The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60. | |||
| REF 7 | High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. J Neurochem. 1999 May;72(5):2127-34. | |||
| REF 8 | [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology. 1997 Apr-May;36(4-5):671-9. | |||
| REF 9 | Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. J Neurochem. 1998 Nov;71(5):2169-77. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.