miRNA General Information
miRNA Mature ID hsa-let-7e-5p
miRNA Stemloop AC MI0000066
miRNA Stemloop ID hsa-let-7e
Sequence ugagguaggagguuguauaguu
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Thrombopoietin receptor (MPL) Successful Target Target Info [2]
Matrix metalloproteinase-9 (MMP-9) Clinical trial Target Target Info [3]
Aurora kinase B (AURKB) Clinical trial Target Target Info [4]
Polo-like kinase 1 (PLK1) Clinical trial Target Target Info [5]
Enhancer of zeste homolog 2 (EZH2) Successful Target Target Info [6]
TRAIL receptor 2 (TRAIL-R2) Clinical trial Target Target Info [7]
G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Target Info [8]
Insulin-like growth factor-I (IGF1) Clinical trial Target Target Info [9]
Zinc finger protein A20 (TNFAIP3) Literature-reported Target Target Info [10]
Apoptosis antigen ligand (CD178) Literature-reported Target Target Info [11]
N-myc proto-oncogene protein (MYCN) Literature-reported Target Target Info [12]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [13]
Protein(s) Regulated by This miRNA AT-rich interactive domain-containing protein 3A Regulated Protein [14]
Eukaryotic translation initiation factor 3 subunit J Regulated Protein [15]
Protein argonaute-1 Regulated Protein [16]
Protein lin-28 homolog A Regulated Protein [4]
Proto-oncogene Wnt-1 Regulated Protein [18]
Structural maintenance of chromosomes protein 1A Regulated Protein [15]
REF 1 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 2 miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood. 2010 Jul 22;116(3):437-45.
REF 3 miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia. Cell Death Dis. 2014 Feb 6;5:e1048.
REF 4 LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res. 2013 Aug 1;73(15):4872-84.
REF 5 Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition. RNA Biol. 2015;12(7):690-700.
REF 6 Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin. Oncogenesis. 2013 Oct 7;2:e75.
REF 7 Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology. 2014 Jan;146(1):278-90.
REF 8 Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e. J Biol Chem. 2011 Nov 25;286(47):40531-5.
REF 9 Upstream and downstream mechanisms for the promoting effects of IGF-1 on differentiation of spermatogonia to primary spermatocytes. Life Sci. 2014 Apr 17;101(1-2):49-55.
REF 10 Let-7 miRNAs Modulate the Activation of NF-B by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis. PLoS One. 2015 Jun 25;10(6):e0121256.
REF 11 Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG. Thromb Res. 2016 Feb;138:30-36.
REF 12 Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma. Br J Cancer. 2011 Jul 12;105(2):296-303.
REF 13 High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol Cancer. 2007 Jan 14;6:5.
REF 14 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma.Cancer Lett. 2017 Jul 10;398:37-45.
REF 15 A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 2004 May 15;18(10):1165-78.
REF 16 Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.J Clin Invest. 2013 Mar;123(3):1057-67.
REF 17 LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res. 2013 Aug 1;73(15):4872-84.
REF 18 MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation.Blood. 2009 Jul 9;114(2):404-14.

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