miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-10b-5p | ||||
miRNA Stemloop AC | MI0000267 | ||||
miRNA Stemloop ID | hsa-mir-10b | ||||
Sequence | uacccuguagaaccgaauuugug | ||||
TTD Target(s) Regulated by This miRNA | Peroxisome proliferator-activated receptor alpha (PPARA) | Successful Target | Target Info | [1] | |
PI3-kinase alpha (PIK3CA) | Successful Target | Target Info | [2] | ||
RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Target Info | [3] | ||
Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [4] | ||
Retinoic acid-inducible gene-1 (RIG-1) | Clinical trial Target | Target Info | [5] | ||
Syndecan-1 (SDC1) | Clinical trial Target | Target Info | [6] | ||
Notch-1 receptor (NOTCH1) | Clinical trial Target | Target Info | [4] | ||
Platelet glycoprotein Ib alpha (CD42b) | Clinical trial Target | Target Info | [7] | ||
Kruppel like factor 4 (KLF4) | Clinical trial Target | Target Info | [8] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [9] | ||
Cyclic AMP-responsive element-binding protein (CREB1) | Literature-reported Target | Target Info | [10] | ||
Neuropilin-2 (NRP2) | Clinical trial Target | Target Info | [11] | ||
Melanoma differentiation-associated protein 6 (CDKN1A) | Literature-reported Target | Target Info | [12] | ||
Multiple tumor suppressor 1 (CDKN2A) | Literature-reported Target | Target Info | [12] | ||
Muscleblind-like protein 1 (MBNL2) | Literature-reported Target | Target Info | [13] | ||
T-lymphoma invasion and metastasis 1 (TIAM1) | Literature-reported Target | Target Info | [14] | ||
Protein(s) Regulated by This miRNA | Bcl-2-like protein 11 | Regulated Protein | [12] | ||
Breast cancer type 1 susceptibility protein | Regulated Protein | [16] | |||
CUB and sushi domain-containing protein 1 | Regulated Protein | [17] | |||
Homeobox protein Hox-B3 | Regulated Protein | [18] | |||
Homeobox protein Hox-D10 | Regulated Protein | [19] | |||
Klotho | Regulated Protein | [20] | |||
Microtubule-associated protein RP/EB family member 1 | Regulated Protein | [21] | |||
Muscleblind-like protein 1 | Regulated Protein | [13] | |||
Muscleblind-like protein 3 | Regulated Protein | [13] | |||
Neurofibromin | Regulated Protein | [23] | |||
Nuclear receptor corepressor 2 | Regulated Protein | [24] | |||
Nuclear receptor subfamily 4 group A member 3 | Regulated Protein | [11] | |||
Oxidoreductase HTATIP2 | Regulated Protein | [26] | |||
Paired box protein Pax-6 | Regulated Protein | [4] | |||
Piezo-type mechanosensitive ion channel component 1 | Regulated Protein | [28] | |||
Programmed cell death protein 4 | Regulated Protein | [29] | |||
Serine/Arginine-related protein 53 | Regulated Protein | [13] | |||
Serine/arginine-rich splicing factor 1 | Regulated Protein | [30] | |||
Squamous cell carcinoma antigen recognized by T-cells 3 | Regulated Protein | [13] | |||
Transcription factor AP-2 gamma | Regulated Protein | [12] | |||
Transformer-2 protein homolog beta | Regulated Protein | [30] | |||
Tropomyosin alpha-1 chain | Regulated Protein | [29] | |||
Zinc finger E-box-binding homeobox 1 | Regulated Protein | [2] | |||
References | |||||
REF 1 | Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD. J Gastroenterol Hepatol. 2010 Jan;25(1):156-63. | ||||
REF 2 | MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation. Cell Physiol Biochem. 2015;35(6):2169-80. | ||||
REF 3 | MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One. 2009 Aug 18;4(8):e6677. | ||||
REF 4 | MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis. 2012 Oct 4;3:e398. | ||||
REF 5 | Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b. Biochem Biophys Res Commun. 2014 Oct 31;453(4):772-7. | ||||
REF 6 | Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion. Fertil Steril. 2013 Mar 1;99(3):871-881.e1. | ||||
REF 7 | MicroRNAs 10a and 10b Regulate the Expression of Human Platelet Glycoprotein Ib for Normal Megakaryopoiesis. Int J Mol Sci. 2016 Nov 9;17(11). pii: E1873. | ||||
REF 8 | MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 2009 May 15;137(4):647-58. | ||||
REF 9 | The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression. Mol Oncol. 2013 Jun;7(3):531-42. | ||||
REF 10 | Oncogenic cAMP responsive element binding protein 1 is overexpressed upon loss of tumor suppressive miR-10b-5p and miR-363-3p in renal cancer. Oncol Rep. 2016 Apr;35(4):1967-78. | ||||
REF 11 | Heparin impairs angiogenesis through inhibition of microRNA-10b. J Biol Chem. 2011 Jul 29;286(30):26616-27. | ||||
REF 12 | Human glioma growth is controlled by microRNA-10b. Cancer Res. 2011 May 15;71(10):3563-72. | ||||
REF 13 | Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 1;8(3):268-87. | ||||
REF 14 | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer. 2015 Jan;18(1):43-54. | ||||
REF 15 | Human glioma growth is controlled by microRNA-10b. Cancer Res. 2011 May 15;71(10):3563-72. | ||||
REF 16 | Identification of miR-10b, miR-26a, miR-146a and miR-153 as potential triple-negative breast cancer biomarkers.Cell Oncol (Dordr). 2015 Dec;38(6):433-42. | ||||
REF 17 | miR-10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 (CSMD1).BMC Cancer. 2016 Oct 18;16(1):806. | ||||
REF 18 | miR-10b Inhibits Apoptosis and Promotes Proliferation and Invasion of Endometrial Cancer Cells via Targeting HOXB3.Cancer Biother Radiopharm. 2016 Aug;31(6):225-31. | ||||
REF 19 | Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.Nature. 2007 Oct 11;449(7163):682-8. | ||||
REF 20 | microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.Mol Biosyst. 2015 Jul;11(7):2051-9. | ||||
REF 21 | Epigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer.Epigenetics. 2011 Jun;6(6):740-51. | ||||
REF 22 | Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 1;8(3):268-87. | ||||
REF 23 | MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1.Cancer Sci. 2010 Sep;101(9):1997-2004. | ||||
REF 24 | MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2.Cell Death Differ. 2011 Jul;18(7):1089-98. | ||||
REF 25 | Heparin impairs angiogenesis through inhibition of microRNA-10b. J Biol Chem. 2011 Jul 29;286(30):26616-27. | ||||
REF 26 | microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF- actions.Oncogene. 2014 Sep 18;33(38):4664-74. | ||||
REF 27 | MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis. 2012 Oct 4;3:e398. | ||||
REF 28 | MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells.Ann Surg Oncol. 2012 Sep;19(9):3065-71. | ||||
REF 29 | Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells.Int J Oncol. 2012 Sep;41(3):1005-12. | ||||
REF 30 | MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2/ASF).J Biol Chem. 2011 Feb 11;286(6):4150-64. | ||||
REF 31 | MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation. Cell Physiol Biochem. 2015;35(6):2169-80. |
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