miRNA General Information
miRNA Mature ID hsa-miR-214-5p
miRNA Stemloop AC MI0000290
miRNA Stemloop ID hsa-mir-214
Sequence ugccugucuacacuugcugugc
TTD Target(s) Regulated by This miRNA Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [1]
Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [2]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [3]
Cyclin-dependent kinase 3 (CDK3) Clinical trial Target Target Info [1]
E3 ubiquitin protein ligase Itchy (ITCH) Literature-reported Target Target Info [4]
Transcription factor E2F2 (E2F2) Literature-reported Target Target Info [1]
Protein(s) Regulated by This miRNA Ras association domain-containing protein 5 Regulated Protein [5]
REF 1 miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators. Oncotarget. 2016 Jan 5;7(1):929-45.
REF 2 MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells. J Biol Chem. 2016 Jul 8;291(28):14662-76.
REF 3 Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. Oncol Rep. 2015 Jun;33(6):3061-8.
REF 4 Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection. Mol Med Rep. 2015 Jul;12(1):1258-64.
REF 5 MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genet Mol Res. 2017 Mar 8;16(1).

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