Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | MTOR complex 2 (RICTOR) | Literature-reported | Target Info | ||
UniProt ID | RICTR_HUMAN | ||||
Gene Name | RICTOR | ||||
Gene ID | 253260 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Serine/threonine-protein kinase mTOR (mTOR) | Target Info | PPI Info | [1] | |
RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [3] | ||
Interacting Clinical trial Target(s) | Glycogen synthase kinase-3 beta (GSK-3B) | Target Info | PPI Info | [2] | |
NAD-dependent deacetylase sirtuin-1 (SIRT1) | Target Info | PPI Info | [4] | ||
Ribosomal protein S6 kinase beta-1 (S6K1) | Target Info | PPI Info | [5] | ||
Target of rapamycin complex 2 MAPKAP1 (MTORC2) | Target Info | PPI Info | [6] |
References | Top | ||||
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REF 1 | SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37. | ||||
REF 2 | ER stress inhibits mTORC2 and Akt signaling through GSK-3-mediated phosphorylation of rictor. Sci Signal. 2011 Feb 22;4(161):ra10. | ||||
REF 3 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18;307(5712):1098-101. | ||||
REF 4 | Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 1;291(1):198-214. | ||||
REF 5 | Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem. 2005 May 20;280(20):19445-8. | ||||
REF 6 | Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10;39(5):797-808. |
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