Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06093 | Target Info | |||
| Target Name | Rho-associated protein kinase 2 (ROCK2) | ||||
| Synonyms |
p164 ROCK-2; Rho-associated, coiled-coil-containing protein kinase II; Rho-associated, coiled-coil-containing protein kinase 2; Rho kinase 2; ROCK-II; KIAA0619
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|
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| Target Type | Successful Target | ||||
| Gene Name | ROCK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 21 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(2-Methoxyethyl)-3-(4-methyl-1,4-diazepan-1-yl)-5-(pyridin-4-yl)pyrazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590238; SCHEMBL13226148; BDBM50309111
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
1-[(1R)-2,3-Dihydro-1H-inden-1-yl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2569131; CHEMBL4114172; BDBM199334; US9221808, 1ct
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| Activity |
IC50 = 52470 nM
|
[2] | |||
| Compound Name |
5-(2-Aminopyridin-4-yl)-3-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591271; SCHEMBL12439974; BDBM50309101
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| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
Nicotinamide, N-(4-pyridyl)-
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Investigative | Compound Info | ||
| Synonyms |
4-Pyridylnicotinamide; N-(4-Pyridyl)nicotinamide; CHEMBL67352; N-(pyridin-4-yl)pyridine-3-carboxamide; BRN 0151186; 3-pyridinecarboxamide, N-4-pyridinyl-; N-Pyridin-4-yl-nicotinamide; Oprea1_539866; 5-22-09-00163 (Beilstein Handbook Reference); SCHEMBL14880208; CTK5C1284; DTXSID30214739; ZINC1513093; 3-pyridyl-N-(4-pyridyl)carboxamide; BDBM50279877; STK395634; 3-Pyridinecarboxamide,N-4-pyridinyl-; AKOS003277605; MCULE-5492045990; ST45023569; Q4637196
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| Activity |
IC50 = 55900 nM
|
[3] | |||
| Compound Name |
3-(4-Methyl-1,4-diazepan-1-yl)-5-(3-methylpyridin-4-yl)pyrazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601935; SCHEMBL12439966; BDBM50309100
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
1-(1H-Indazol-5-yl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2023148; SCHEMBL15147870; ZINC5642583; BDBM50382698; AKOS024378986; MCULE-9325869187; N-(1H-indazol-5-yl)(phenylamino)carboxamide; ST51023794
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| Activity |
IC50 = 61800 nM
|
[3] | |||
| Compound Name |
3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(2-piperidin-4-yl-ethyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589845; SCHEMBL307709; BDBM50308895; 3-[[(4-cyanophenyl)carbamoylamino]methyl]-N-(2-piperidin-4-ylethyl)benzamide
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| Activity |
IC50 = 65000 nM
|
[4] | |||
| Compound Name |
N-(4-Aminomethyl-phenyl)-3-[3-(4-cyano-phenyl)-ureidomethyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590826; SCHEMBL307067; BDBM50308860; N-[4-(aminomethyl)phenyl]-3-[[(4-cyanophenyl)carbamoylamino]methyl]benzamide
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| Activity |
IC50 = 70000 nM
|
[4] | |||
| Compound Name |
3-[3-(3-Chloro-4-amido-phenyl)-ureidomethyl]-N-(4-dimethylaminomethyl-phenyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591355; SCHEMBL10159843; BDBM50308857
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| Activity |
IC50 = 74000 nM
|
[4] | |||
| Compound Name |
Chembl4167272
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Investigative | Compound Info | ||
| Synonyms |
Cyclizidine B; BDBM50286631
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4171044
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|
Investigative | Compound Info | ||
| Synonyms |
Cyclizidine G; BDBM50286624
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin-6-ylcarbamoyl)-benzyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597126; SCHEMBL306739; BDBM50308873; 3,4-dimethoxy-N-[[3-(1,2,3,4-tetrahydroisoquinolin-6-ylcarbamoyl)phenyl]methyl]benzamide
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(4-Methyl-1,4-diazepan-1-yl)-5-(2-methylpyridin-4-yl)pyrazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589656; BDBM50309099
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4174482
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|
Investigative | Compound Info | ||
| Synonyms |
Cyclizidine E; BDBM50286625
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Cyclizidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4172688; (+)-Cyclizidine; BDBM50286626
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4163816
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|
Investigative | Compound Info | ||
| Synonyms |
Cyclizidine D; BDBM50286629
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3,4-Dimethoxy-N-{3-[2-(1-methyl-piperidin-3-yl)-ethylcarbamoyl]-benzyl}-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604789; SCHEMBL306732; BDBM50308893; 3,4-dimethoxy-N-[[3-[2-(1-methylpiperidin-3-yl)ethylcarbamoyl]phenyl]methyl]benzamide
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|
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| Activity |
IC50 = 102000 nM
|
[4] | |||
| Compound Name |
N-{3-[3-(4-Cyano-phenyl)-ureidomethyl]-phenyl}-3-piperidin-3-yl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589844; SCHEMBL306941; BDBM50308892; N-[3-[[(4-cyanophenyl)carbamoylamino]methyl]phenyl]-3-piperidin-3-ylpropanamide
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|
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| Activity |
IC50 = 110000 nM
|
[4] | |||
| Compound Name |
5-Aminoindazole
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|
Investigative | Compound Info | ||
| Synonyms |
1H-Indazol-5-amine; 5-Amino-1H-indazole; 2H-Indazol-5-amine; 1H-Indazole-5-amine; 5-Indazolamine; 1H-Indazole, 5-amino-; 5-AMINOBENZOPYRAZOLE; 1H-Indazol-5-ylamine; 5-Amino-indazole; MFCD00037975; 1~{h}-Indazol-5-Amine; UNII-A5B06TDT72; CHEMBL17551; MLS000069421; A5B06TDT72; Indazol-5-ylamine; 1H-indazole-5-ylamine; SMR000059094; EINECS 242-971-5; NSC 44676; 5aminoindazole; 5-aminoindazol; AI3-52443; 5-aminoazaindole; 5-Aminoisoindazole; PubChem8628; 1-H-indazol-5-amine; 5-Aminoindazole, 97%; Opera_ID_1647; ACMC-1C7ZX; cid_88012; KSC179Q3T; MLS001076528; SCHEMBL117208; DTXSID2066480; CTK0H9839; CTK3H5141; HMS2232B16; HMS3371D15; ZINC152290; ACN-S003653; ALBB-021330; BCP00021; NSC44676; ANW-23596; BBL104266; BDBM50304148; NSC-44676; SBB006576; STL558474; AKOS005203106; AB01685; AC-1055; BCP9000065; CS-W008621; MCULE-2886869012; SB11754; SDCCGMLS-0003169.P003; VP20129; NCGC00018111-01; NCGC00018111-02; NCGC00018111-03; NCGC00018111-04; AK-23803; BR-23803; DA-00909; SC-02100; SY002725; TS-01719; DB-013846; A0797; AM20030258; FT-0620016; FT-0762293; ST50984730; X4400; L-1479; 12836-EP2281563A1; 12836-EP2295412A1; 12836-EP2295413A1; 12836-EP2295432A1; 12836-EP2316831A1; AB00384262-15; AE-562/40222977; W-206426; F2108-0020
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|
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| Activity |
IC50 = 119700 nM
|
[3] | |||
| Compound Name |
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-3-trifluoromethyl-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589102; SCHEMBL307408; BDBM50308865
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|
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| Activity |
IC50 = 160000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 22 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Chloro-N-pyridin-4-ylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022282; SCHEMBL15140751; BDBM50382699; AKOS019797121
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|
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| Activity |
IC50 = 221400 nM
|
[3] | |||
| Compound Name |
3-[3-(3-Amido-phenyl)-ureidomethyl]-N-(4-dimethylaminomethylphenyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603162; SCHEMBL10159840; BDBM50308856
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|
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| Activity |
IC50 = 240000 nM
|
[4] | |||
| Compound Name |
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-3-methyl-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604249; SCHEMBL307149; BDBM50308867; N-[[3-[[4-[(dimethylamino)methyl]phenyl]carbamoyl]phenyl]methyl]-4-methoxy-3-methylbenzamide
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|
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| Activity |
IC50 = 266000 nM
|
[4] | |||
| Compound Name |
5-Bromo-N-(pyridin-4-yl)pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1566648; 5-bromo-N-(pyridin-4-yl)nicotinamide; 5-bromo-N-pyridin-4-ylpyridine-3-carboxamide; MLS000099903; SCHEMBL15140299; 5-bromo-N-4-pyridinylnicotinamide; HMS2481J17; BDBM50382700; STK865618; ZINC38140742; AKOS003597332; MCULE-8348193797; SDCCGMLS-0010285.P002; SMR000081042; ST45023554; (5-bromo(3-pyridyl))-N-(4-pyridyl)carboxamide; Z57474837
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|
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| Activity |
IC50 = 357200 nM
|
[3] | |||
| Compound Name |
5-(4-Fluorophenyl)-N-pyridin-4-ylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2023145; SCHEMBL15140558; BDBM50382702
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|
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| Activity |
IC50 > 400000 nM
|
[7] | |||
| Compound Name |
4-(4-Fluorophenyl)-N-pyridin-4-ylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2023144; SCHEMBL15140686; BDBM50382701
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|
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| Activity |
IC50 > 400000 nM
|
[7] | |||
| Compound Name |
3-Chloro-N-[3-(4-dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-trifluoromethoxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602437; SCHEMBL307125; BDBM50308864
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|
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| Activity |
IC50 = 670000 nM
|
[4] | |||
| Compound Name |
N-[3-(Isoquinolin-6-ylcarbamoyl)-benzyl]-3,4-dimethoxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597734; BDBM50308891
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|
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| Activity |
IC50 = 685000 nM
|
[4] | |||
| Compound Name |
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589827; SCHEMBL307583; BDBM50308869; N-[4-[(dimethylamino)methyl]phenyl]-3-[[(4-methoxybenzoyl)amino]methyl]benzamide
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|
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| Activity |
IC50 = 1300000 nM
|
[4] | |||
| Compound Name |
3-[3-(3,4-Dimethoxy-phenyl)-ureidomethyl]-N-(2-piperidin-3-ylethyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602238; SCHEMBL307684; BDBM50308882; 3-[[(3,4-dimethoxyphenyl)carbamoylamino]methyl]-N-(2-piperidin-3-ylethyl)benzamide
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|
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| Activity |
IC50 = 1600000 nM
|
[4] | |||
| Compound Name |
4-Cyano-N-[3-(4-dimethylaminomethyl-phenylcarbamoyl)-benzyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589117; SCHEMBL307789; BDBM50308863; 3-[[(4-cyanobenzoyl)amino]methyl]-N-[4-[(dimethylamino)methyl]phenyl]benzamide
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|
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| Activity |
IC50 = 1700000 nM
|
[4] | |||
| Compound Name |
3-[2-(3,4-Dimethoxy-phenyl)-acetylamino]-N-(2-piperidin-3-ylethyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592715; BDBM50308890
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|
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| Activity |
IC50 = 3200000 nM
|
[4] | |||
| Compound Name |
3-[(3,4-Dimethoxy-benzenesulfonylamino)-methyl]-N-(2-piperidin-3-yl-ethyl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603157; BDBM50308883
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|
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| Activity |
IC50 > 6000000 nM
|
[4] | |||
| Compound Name |
N-(3,4-Dimethoxy-benzyl)-N-(2-piperidin-3-yl-ethyl)-isophthalamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592714; BDBM50308885
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|
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| Activity |
IC50 > 6000000 nM
|
[4] | |||
| Compound Name |
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-3,4-dihydroxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590072; BDBM50308868
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|
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| Activity |
IC50 > 6000000 nM
|
[4] | |||
| Compound Name |
3,4-Dimethoxy-N-[3-(2-piperidin-3-yl-ethylcarbamoyl)-phenyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592299; BDBM50308884
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|
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| Activity |
IC50 > 6000000 nM
|
[4] | |||
| Compound Name |
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-3-methoxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590323; SCHEMBL306324; BDBM50308870; N-[4-[(dimethylamino)methyl]phenyl]-3-[[(3-methoxybenzoyl)amino]methyl]benzamide
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|
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| Activity |
IC50 > 7000000 nM
|
[4] | |||
| Compound Name |
4-Methoxy-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)-benzyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596708; BDBM50308889
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|
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| Activity |
IC50 > 7000000 nM
|
[4] | |||
| Compound Name |
3-[(3,4-Dimethoxyphenyl)carbamoylamino]-N-(2-piperidin-3-ylethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163034; BDBM50378682
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|
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| Activity |
IC50 > 7000000 nM
|
[4] | |||
| Compound Name |
3-Methoxy-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)-benzyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591914; BDBM50308888
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|
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| Activity |
IC50 > 7000000 nM
|
[4] | |||
| Compound Name |
3,4-Dimethyl-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)-benzyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610211; BDBM50308886
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|
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| Activity |
IC50 > 7000000 nM
|
[4] | |||
| Compound Name |
1,3-Benzodioxole-5-carboxylic acid 3-(2-pyridin-4-yl-ethylcarbamoyl)-benzylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597534; BDBM50308887
Click to Show/Hide
|
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| Activity |
IC50 > 7000000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2,3-Diaminopyrazines as Rho kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1137-40. | ||||
| REF 2 | US patent application no. 9221808B2, Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use | ||||
| REF 3 | US patent application no. 9409868B2, Inhibitors of rho associated protein kinases (ROCK) and methods of use | ||||
| REF 4 | Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. J Med Chem. 2010 Jan 28;53(2):759-77. | ||||
| REF 5 | Cyclizidine-Type Alkaloids from Streptomyces sp. HNA39. J Nat Prod. 2018 Feb 23;81(2):394-399. | ||||
| REF 6 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 7 | Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J Med Chem. 2012 Mar 8;55(5):2474-8. | ||||
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