Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16117 | Target Info | |||
| Target Name | Nitric-oxide synthase brain (NOS1) | ||||
| Synonyms |
Peptidyl-cysteine S-nitrosylase NOS1; Nitric oxide synthase, brain; Neuronal NOS; NOS, type I; NOS type I; NNOS; NC-NOS; N-NOS; BNOS
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| Target Type | Clinical trial Target | ||||
| Gene Name | NOS1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 145 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chlorzoxazone
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|
Approved | Compound Info | ||
| Synonyms |
Biomioran; CLW; Chloroxazone; Chlorsoxazone; Chlorzoxane; Chlorzoxazon; Chlorzoxazona; Chlorzoxazonum; Clorzoxazona; Escoflex; Klorzoxazon; Mioran; Miotran; Myoflexin; Myoflexine; Neoflex; Nyoflex; Paraflex; Parafon; Pathorysin; Relaxazone; Remofleks; Remular; Solaxin; Component of Parafon Forte; McNeil Brand of Chlorzoxazone; Ortho Brand of Chlorzoxazone; Parafon Forte; Parafon Forte DSC; Strifon Forte Dsc; C 4397; Chlorzoxazonum [INN-Latin]; Clorzoxazona [INN-Spanish]; EZE-DS; Muscol (TN); Paraflex (TN); Parafon Forte (TN); Remular-S; Usaf ma-10; Chlorzoxazone [INN:BAN:JAN]; Chlorzoxazone (JAN/USP/INN); 2-Hydroxy-5-chlorobenzoxazole; 5-Chlorbenzoxazolin-2-on; 5-Chloro-1,3-benzoxazol-2(3H)-one; 5-Chloro-2(3H)-benzoxazolone; 5-Chloro-2-benzoxazolinone; 5-Chloro-2-benzoxazolol; 5-Chloro-2-benzoxazolone; 5-Chloro-2-hydroxybenzoxazole; 5-Chloro-3(H)-2-benzoxazolone; 5-Chlorobenzoksazolinon-2; 5-Chlorobenzoksazolinon-2 [Polish]; 5-Chlorobenzoksazolon-2; 5-Chlorobenzoksazolon-2 [Polish]; 5-Chlorobenzoxazol-2-one; 5-Chlorobenzoxazolidone; 5-Chlorobenzoxazolone; 5-chloro-1,3-benzoxazol-2-ol; 5-chloro-3H-1,3-benzoxazol-2-one; 5-chlorobenzoxazolin-2-one
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
GW274150
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Phase 2 | Compound Info | ||
| Synonyms |
GW274150; GW-274150; UNII-0ZZF1V8G63; 0ZZF1V8G63; CHEMBL114551; SCHEMBL120693; L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-; GTPL9849; ZINC2004483; BDBM50086467; AKOS030526714; DB12237; CS-5419; HY-12119; GW-274150;GW 274150; [2-[(1-iminoethyl) amino]ethyl]-L-homocysteine; (S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid; (2S)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid
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| Activity |
IC50 = 144543.98 nM
|
[2] | |||
| Compound Name |
Aminoguanidine
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Phase 1 | Compound Info | ||
| Synonyms |
aminoguanidine; Pimagedine; Hydrazinecarboximidamide; Guanyl hydrazine; Monoaminoguanidine; 2-aminoguanidine; 79-17-4; Imino semicarbazide; Aminate base; 2-azanylguanidine; Pimagedine [INN]; GUANIDINE, AMINO-; 1-aminoguanidine; UNII-SCQ4EZQ113; Hydrazinecarboximidamide(9CI); CCRIS 3511; EINECS 201-183-1; Aminoguanidine, Hemisulfate; SCQ4EZQ113; CHEMBL225304; CHEBI:40618; HAMNKKUPIHEESI-UHFFFAOYSA-N; guanylhydrazine; GER-11; AGU; amino guanidine; 1-amino-guanidine; Aminoguanidine (AG); Tocris-0787; Carbonohydrazonic diamide; INCB3284
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| Activity |
IC50 = 118000 nM
|
[3] | |||
| Compound Name |
2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
37910-79-5; n-(4-nitrophenacyl)imidazole; CHEMBL162549; 2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone; Ethanone, 2-(1H-imidazol-1-yl)-1-(4-nitrophenyl)-; AC1Q5DPC; 2-imidazol-1-yl-1-(4-nitrophenyl)ethanone; AC1Q1XG1; SCHEMBL5730977; AC1L1F83; CTK1A9243; DTXSID00275594; BDBM50240895; ZINC19595447; AKOS009984680; 2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone; I90114; alpha-(1H-Imidazole-1-yl)-4'-nitroacetophenone; 2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)-ethanone
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| Activity |
Ki = 105000 nM
|
[4] | |||
| Compound Name |
6-Hydroxymethylpterin
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Investigative | Compound Info | ||
| Activity |
IC50 = 180000 nM
|
[5] | |||
| Compound Name |
2-Methyl-octahydro-benzo[b][1,4]thiazepin-(4E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186360; BDBM50155781
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-Methyl-1,3-benzoxazol-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
5-Methylbenzo[d]oxazol-2(3H)-one; 5-methyl-3H-1,3-benzoxazol-2-one; CHEMBL101439; 5-Methyl-3H-benzooxazol-2-one; NSC280710; 5-methyl-2,3-dihydro-1,3-benzoxazol-2-one; 5-methyl-2-benzoxazolinone; SCHEMBL243203; SCHEMBL8346086; 5-Methyl-3H-benzoxazol-2-one; 5-Methylbenzoxazol-2(3H)-one; CTK4F0372; 2(3H)-Benzoxazolone,5-methyl-; DTXSID20314111; 5-Methylbenzo[d]oxazol-2-one .; ZINC163634; 2(3H)-Benzoxazolone, 5-methyl-; 2-Hydroxy-5-methylbenzo[d]oxazole; ACT08265; ALBB-013600; BDBM50290810; MFCD02090048; STK878620; AKOS000404382; MCULE-6074705530; NSC-280710; 5-methyl-1,3-benzoxazol-2 (3H)-one; FT-0683761; V4530; EN300-51496; W-9071; 5-Methyl-1,3-benzoxazol-2(3H)-one, AldrichCPR
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
6-Methyl-[1,4]thiazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188073; BDBM50155791; AKOS006379603
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5(N-Phenylthiocarbamoyl)-5,6,7,8-tetrahydropterin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100113; BDBM50115167; 2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pteridine-5-carbothioic acid phenylamide
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
6,7-Dihydro-5H-cyclopenta[b]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
2-amino-6,7-dihydro-5h-1-pyrindine; CHEMBL292690; 5H,6H,7H-cyclopenta[b]pyridin-2-amine; 5H-Cyclopenta[b]pyridin-2-amine, 6,7-dihydro-; SCHEMBL3162510; BDBM50091795; ZINC18531795; AKOS004120953; 6,7-Dihydro-5H-[1]pyrindin-2-ylamine; Z1198183883
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Hexahydro-indolizin-(3E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185600; BDBM50150925
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-[4-(1-Aminoethylideneamino)phenyl]acetic acid;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL555389
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
5-Methyloxazolo[5,4-b]pyridin-2-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97163; SCHEMBL15046535; BDBM50290813; ZINC26724637; 5-Methyl-1H-oxazolo[5,4-b]pyridin-2-one; 5-methyloxazolo[5,4-b]pyridin-2(1H)-one; 5-methyl[1,3]oxazolo[5,4-b]pyridin-2-ol
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
5-Fluorobenzo[d]oxazol-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
5-Fluoro-1,3-benzoxazol-2(3H)-one; 5-Fluoro-2(3H)-benzoxazolone; 5-fluoro-3H-1,3-benzoxazol-2-one; 5-Fluoro-3H-benzooxazol-2-one; CHEMBL101266; MFCD08059539; 5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one; 5-Fluorobenzoxazol-2(3H)-one; NSC146763; ACMC-20am3n; 5-fluoro-benzoxazol-2-one; 5-Fluoro-2-benzoxazolinone; 5-Fluorobenzoxazolin-2-one; SCHEMBL244162; 5-Fluoro-3H-benzoxazol-2-one; CTK4B9228; KS-00000SFR; 2(3H)-Benzoxazolone,5-fluoro-; DTXSID50301852; 5-fluoro-3-hydrobenzoxazol-2-one; 5-Fluoro-2-hydroxybenzo[d]oxazole; ZINC1728885; BDBM50290804; EBD177944; SBB086882; AKOS011655126; 5-Fluoro-2(3H)-benzoxazolone, 96%; CCG-339791; DS-9112; NSC-146763; 5-fluoranyl-3H-1,3-benzoxazol-2-one; 5-Fluoro-2,3-dihydrobenzoxazole-2-one; AK157798; BP-13411; SY101449; CS-0038220; Z9761; A-8554; A806789; J-006548; Z1889710358
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Acetimidoylamino-Benzoic Acid HCl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540555
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
5-Methyl-4,5-dihydro-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185505; 5-methyl-4,5-dihydro-thiazol-2-ylamine; 2-amino-5-methylthiazoline; SCHEMBL6637787; SCHEMBL9870593; 2-amino-5-methyl-2-thiazoline; 5-methyl-1,3-thiazolidin-2-imine; BDBM50150913; AKOS006220699; MCULE-5641549444; 5-Methyl-thiazolidin-(2E)-ylideneamine; Thiazole, 2-amino-4,5-dihydro-5-methyl-; 5-Methyl-4,5-dihydro-1,3-thiazol-2-amine #
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-Cyclopropyl-pyrazole-1-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL502771; CHEMBL543853; BDBM50095173; BDBM50271649; N-Cyclopropyl-1H-pyrazole-1-carboxamidine; N-Cyclopropyl-1H-pyrazole-1-carboximidamide; N-Cyclopropyl-pyrazole-1-carboxamidine; hydrochloride
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| Activity |
Ki = 50000 nM
|
[4] | |||
| Compound Name |
Hexahydro-thiazolo[3,4-a]pyridin-(3Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185867; BDBM50150934
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Methyl 2-[4-(1-aminoethylideneamino)phenyl]acetate;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL545256
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
Ethyl 4''-amino-1H,1''H-spiro[piperidine-4,2''-thieno[3,2-d]pyrimidine]-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL170176; BDBM50124528; ethyl 4''-aminospiro[hexahydropyridine-4,2''-(1'',2''-dihydrothieno[3,2-d]pyrimidine)]-1-carboxylate
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
4-Methyl-1,3-benzoxazol-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
4-Methylbenzoxazol-2(3H)-one; 4-Methyl-3H-benzooxazol-2-one; CHEMBL320850; 4-methyl-3H-benzoxazol-2-one; MFCD16742805; 4-methyl-2,3-dihydro-1,3-benzoxazol-2-one; methyl-benzoxazolinone; SCHEMBL1285749; 4-Methylbenzoxazole-2(3H)-one; 4-methyl-3H-benz-oxazol-2-one; 2(3H)-Benzoxazolone, 4-methyl-; 2-Hydroxy-4-methylbenzo[d]oxazole; KS-00003T1Q; 4-methylbenzo[d]oxazol-2(3H)-one; BDBM50290809; ZINC26728949; AKOS011655123; SB22918; SY130158; TS-01951; DB-123531; 4-METHYL-3H-1,3-BENZOXAZOL-2-ONE
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Phenyl-4,5-dihydro-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183268; SCHEMBL6257456; 4-phenyl-1,3-thiazolidin-2-imine; BDBM50150917; MCULE-6223280688; 4-Phenyl-thiazolidin-(2E)-ylideneamine
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N'-(4-Hydroxyphenyl)ethanimidamide;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542912
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
N'-(4-Methoxyphenyl)ethanimidamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL544093; SR-01000439374; SR-01000439374-1
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
N-[3-(Aminomethyl)phenyl]-N'-methylethanimidamide;dihydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL544559
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
5-Chloro-2-mercaptobenzoxazole
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Investigative | Compound Info | ||
| Synonyms |
5-chlorobenzo[d]oxazole-2-thiol; 5-chloro-1,3-benzoxazole-2-thiol; 5-Chlorobenzooxazole-2-thiol; 5-Chlorobenzo[d]oxazole-2(3H)-thione; 5-chloro-benzooxazole-2-thiol; 2(3H)-Benzoxazolethione, 5-chloro-; 5-chloro-3H-1,3-benzoxazole-2-thione; 2-Mercapto-5-chlorobenzoxazole; 5-Chloro-2-thioxobenzoxazoline; 2-Benzoxazolethiol, 5-chloro-; BENZOXAZOLE, 5-CHLORO-2-MERCAPTO-; 5-Chloranyl-3~{h}-1,3-Benzoxazole-2-Thione; CHEMBL99703; 5-CHLOROBENZOXAZOLE-2-THIOL; MFCD00175241; 5-chloro-3-hydrobenzoxazole-2-thione; 2-Benzoxazolinethione, 5-chloro-; NSC 26187; NSC26187; PubChem8704; ACMC-20am4o; Maybridge1_007032; SCHEMBL777690; 5-chloro-2-mercapto-benzoxazol; CTK6H2118; HMS561H14; DTXSID10177419; ZINC349058; 5-Chloro-2-mercaptobenzo[d]oxazole; 5-Chloro-3H-benzooxazole-2-thione; ACT09314; ALBB-004124; BCP15804; CS-M1396; EBD24321; BBL025677; BDBM50290805; CCG-54507; NSC-26187; SBB003707; STK502094; 5-Chloro-2-mercaptobenzoxazole, 97%; 5-Chlorobenzo[d]oxazole-2(3H)thione; AKOS000116656; AKOS015912994; AB04398; AS07121; DS-2753; MCULE-7527631705; KS-00000F42; 2-Benzoxazolinethione, 5-chloro- (8CI); 5-Chloro-1,3-benzoxazole-2(3H)-thione; AK111072; AM803553; BP-10021; ST059829; AB0005810; DB-021258; DB-029117; BB 0240843; FT-0638260; Z4453; 2(3H)-Benzoxazolethione, 5-chloro- (9CI); EN300-04022; 4B-098; M-7804; 5-chloro-2,3-dihydro-1,3-benzoxazole-2-thione; 876C193; SR-01000643599-1; W-201953; Q27456066; Z56824483
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[(1R)-1-Amino-4-(diaminomethylideneamino)butyl]boronic acid;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448330; BDBM50071730
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
3-Phenyl-3,4-dihydro-2h-pyrrol-5-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364781; BRN 0472717; 3,4-Dihydro-3-phenyl-2H-pyrrol-5-amine; 2H-Pyrrol-5-amine, 3,4-dihydro-3-phenyl-; 4-Phenylpyrrolidin-2-imine; 5-22-10-00040 (Beilstein Handbook Reference); SCHEMBL11497728; DTXSID80945001; BDBM50150918; 4-Phenyl-pyrrolidin-(2Z)-ylideneamine
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-(1-aminoethylideneamino)benzoate;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542909
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
2,3,6,7-Tetrahydro-1H-1,4-diazepin-5-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361049; SCHEMBL2760930; [1,4]Diazepan-(5E)-ylideneamine; BDBM50155793; AKOS006379981
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-Oxo-2,3-dihydrobenzo[d]oxazole-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
2-Oxo-2,3-dihydro-benzooxazole-5-carbonitrile; CHEMBL319485; 2-OXO-3H-1,3-BENZOXAZOLE-5-CARBONITRILE; 2-oxo-2,3-dihydro-1,3-benzoxazole-5-carbonitrile; 5-Benzoxazolecarbonitrile, 2,3-dihydro-2-oxo-; SCHEMBL1423023; 5-Cyano-2-hydroxybenzo[d]oxazole; 1843AJ; BDBM50290817; MFCD11845136; ZINC26742571; AKOS022794309; SB35165; DA-08511; 2,3-dihydro-2-oxo-5-benzoxazolecarbonitrile; FT-0719546; Z-5879; Z2752201053
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
N'-[4-(2-Morpholin-4-yl-2-oxoethyl)phenyl]ethanimidamide;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL539802
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
Cbz-L-Arg NO2-L-Dbu-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98383; BDBM50090933
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| Activity |
Ki = 52000 nM
|
[11] | |||
| Compound Name |
4-Propyl-pyrrolidin-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361909; SCHEMBL7592097; SCHEMBL13750953; BDBM50150931; AKOS006376872; 3-propyl-3,4-dihydro-2H-pyrrol-5-amine
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| Activity |
IC50 = 53000 nM
|
[7] | |||
| Compound Name |
S-{2-[(E)-(1-Aminoethylidene)amino]ethyl}-L-cysteine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL351787; SCHEMBL5511756; CTK0A7450; DTXSID10658511; BDBM50086461; S-[2-(1-Iminoethylamino)ethyl]-L-cysteine; L-Cysteine, S-[2-[(1-iminoethyl)amino]ethyl]-; (R)-3-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-propionic acid; (2R)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]propanoic acid
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| Activity |
IC50 = 53000 nM
|
[12] | |||
| Compound Name |
Benzyl (2S)-2-[[(2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoyl]amino]-3-phenylpropanoate;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202112
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| Activity |
Ki = 55000 nM
|
[13] | |||
| Compound Name |
1-[6-(4-Bromophenoxy)hexyl]imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL484291; CTK4J8550; DTXSID00385783; ZINC6110405; BDBM50271514; MCULE-1315668982; 1-(6-(4-bromophenoxy)hexyl)-1H-imidazole; SR-01000207233; SR-01000207233-1
Click to Show/Hide
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| Activity |
Ki = 57000 nM
|
[4] | |||
| Compound Name |
4-[[Amino(ethylsulfanyl)methylidene]amino]benzoic acid;hydroiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL552852
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| Activity |
Ki = 58000 nM
|
[14] | |||
| Compound Name |
(2R)-2-Amino-2-[2-(diaminomethylideneamino)ethylsulfanylmethyl]-3-methoxypropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916075
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[15] | |||
| Compound Name |
7-Methoxy-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800530; BDBM50418853
Click to Show/Hide
|
||||
| Activity |
IC50 = 58884.37 nM
|
[2] | |||
| Compound Name |
4-Piperidino-6-(4-methoxyphenyl)pteridine-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451487; SCHEMBL5512348; BDBM50081590; ZINC13474484; 6-(4-methoxyphenyl)-4-piperidin-1-ylpteridin-2-amine; 6-(4-Methoxy-phenyl)-4-piperidin-1-yl-pteridin-2-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
N-Pentyl-1H-pyrazole-1-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468421; CHEMBL553998; BDBM50095178; N-Pentyl-pyrazole-1-carboxamidine; hydrochloride
Click to Show/Hide
|
||||
| Activity |
Ki = 60000 nM
|
[4] | |||
| Compound Name |
1-(4-(3-Bromophenoxy)butyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482686; 1-[4-(3-Bromophenoxy)butyl]-1H-imidazole; BDBM50271549
Click to Show/Hide
|
||||
| Activity |
Ki = 60000 nM
|
[4] | |||
| Compound Name |
3-(4-Benzoyl-phenyl)-propionic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419723; PHS-176; BDBM50115169
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
Ethyl 4-[(4-chloropyridin-2-yl)amino]piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221660; SCHEMBL21067374; BDBM36400; DB07306; CID24894151; Q27096533; Ethyl 4-[(4-chloropyridin-2-yl)amino]piperidine-1-carboxylate, 10
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[16] | |||
| Compound Name |
2-Amino-6-phenoxymethyl-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101267; BDBM50115137
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[5] | |||
| Compound Name |
Propyl N'-[4-(trifluoromethyl)phenyl]carbamimidothioate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541552
Click to Show/Hide
|
||||
| Activity |
Ki = 64000 nM
|
[14] | |||
| Compound Name |
(S)-2-Amino-6-(1H-imidazol-5-yl)hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484913; BDBM50271554
Click to Show/Hide
|
||||
| Activity |
Ki = 65000 nM
|
[4] | |||
| Compound Name |
2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98102; SCHEMBL3760493; BDBM50115154; 2-amino-6-(4-fluorophenyl)-1H-pteridin-4-one; 2-Amino-6-(4-fluoro-phenyl)-3H-pteridin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 65510 nM
|
[17] | |||
| Compound Name |
(S)-3-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157958; BDBM50086468
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[12] | |||
| Compound Name |
5-Chloro-3-[(methyl-phenethyl-amino)-methyl]-3H-benzooxazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317806; BDBM50290812
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[1] | |||
| Compound Name |
(4-Amino-5-fluorospiro[1H-quinazoline-2,4'-piperidine]-1'-yl)-thiophen-3-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL170580; SCHEMBL7939630; BDBM50124525; 5''-fluoro-1-(thien-3-ylcarbonyl)-1''H-spiro[piperidine-4,2''-quinazolin]-4''-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[9] | |||
| Compound Name |
(S)-2-Amino-7-(1-phenyl-1H-imidazol-5-yl)heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450160; BDBM50271593
Click to Show/Hide
|
||||
| Activity |
Ki = 70000 nM
|
[4] | |||
| Compound Name |
6-Acetimidoylamino-2-amino-5-fluoro-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172867; BDBM50139792; 2-amino-6-(1-aminoethylideneamino)-5-fluorohexanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 70400 nM
|
[18] | |||
| Compound Name |
N',N'-Dimethyl-6-(4-methoxyphenyl)pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100932; SCHEMBL5513451; BDBM50081580; 6-(4-methoxyphenyl)-4-N,4-N-dimethylpteridine-2,4-diamine; 6-(4-Methoxy-phenyl)-N*4*,N*4*-dimethyl-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[5] | |||
| Compound Name |
2-(2-Methylimidazol-1-yl)-1-(4-nitrophenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447987; SCHEMBL5738976; CTK1B1278; DTXSID80438963; BDBM50271594; 2-(2-methyl-imidazol-1-yl)-1-(4-nitrophenyl)-ethanone; 2-(2-methyl-1H-imidazol-1-yl)-1-(4-nitrophenyl)ethanone; Ethanone, 2-(2-methyl-1H-imidazol-1-yl)-1-(4-nitrophenyl)-
Click to Show/Hide
|
||||
| Activity |
Ki = 74000 nM
|
[4] | |||
| Compound Name |
1-(3-(4-(Trifluoromethyl)phenoxy)propyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483706; SCHEMBL8685446; BDBM50271515
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[4] | |||
| Compound Name |
N*4*,N*4*-Dimethyl-6-p-tolyl-pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101513; SCHEMBL5516535; BDBM50115157; ZINC13474471; 4-N,4-N-dimethyl-6-(4-methylphenyl)pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[5] | |||
| Compound Name |
(S)-2-Amino-5-(1-phenyl-1H-imidazol-5-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485526; BDBM50271591
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[4] | |||
| Compound Name |
2-Amino-6-decyloxymethyl-5,6,7,8-tetrahydro-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101494; BDBM50115173
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[5] | |||
| Compound Name |
4-Morpholino-6-phenylpteridine-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98577; SCHEMBL5317835; BDBM50081593; 4-morpholin-4-yl-6-phenylpteridin-2-amine; 4-Morpholin-4-yl-6-phenyl-pteridin-2-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[5] | |||
| Compound Name |
2-Amino-6-naphthalen-1-yl-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188157; BDBM50170721
Click to Show/Hide
|
||||
| Activity |
IC50 = 85100 nM
|
[17] | |||
| Compound Name |
(2R)-2-Amino-3-[(2R)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951128
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[15] | |||
| Compound Name |
2-Amino-6-methylsulfanylmethyl-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318704; BDBM50115149
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[5] | |||
| Compound Name |
2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101495; BDBM50115136
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[5] | |||
| Compound Name |
Methyl (2R)-5-[[amino(nitramido)methylidene]amino]-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]pentanoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204425
Click to Show/Hide
|
||||
| Activity |
Ki = 90000 nM
|
[13] | |||
| Compound Name |
Methyl (2R)-2-[[(2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoyl]amino]-3-phenylpropanoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202113
Click to Show/Hide
|
||||
| Activity |
Ki = 92000 nM
|
[13] | |||
| Compound Name |
N-(4-Isobutyrylamino-6,7-diphenyl-pteridin-2-yl)-isobutyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101598; BDBM50115127
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[5] | |||
| Compound Name |
1-(4-(4-(Trifluoromethyl)phenoxy)butyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503013; BDBM50271516
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[4] | |||
| Compound Name |
4-(4-Ethoxy-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112198; BDBM50148166
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[19] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrol-1-yl]-N-methylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911980; BDBM50356499
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
3-Chloro-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-chloro-2H-indazole; 1H-Indazole, 3-chloro-; 3-Chloroindazole; UNII-UYV55A79UH; UYV55A79UH; CHEMBL596385; 3-Chloro-1H-indazole, 99%; 2H-Indazole, 3-chloro-; NSC42179; EINECS 249-444-9; 1H-Indazole,3-chloro-; 3-Chloroindazole, 97%; ACMC-1CIO6; KSC205K5H; SCHEMBL844487; CTK1A5553; DTXSID60183363; NSC44503; ZINC3852548; ANW-51462; BBL018266; BDBM50304147; GEO-00691; MFCD00067527; NSC-42179; NSC-44503; SBB004051; STL134669; AKOS005744919; AKOS024124975; AB02730; DS-0475; FS-2830; MCULE-6762044487; KS-0000101Q; AK-25715; BP-21251; BR-25715; NCI60_003959; ST059595; AB0024003; BB 0218332; FT-0615296; FT-0615487; W5175; S-5787; AC-907/25014153; W-200283
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
2-[3-(1,3-Benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]-N,N-dimethylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911995; SCHEMBL3558781; BDBM50356493
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Benzyl-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911885; SCHEMBL3567859; BDBM50356507
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
n-Methyl-3,4,5,6-tetrahydropyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268294; NSC157920; 2-PYRIDINAMINE, 3,4,5,6-TETRAHYDRO-N-METHYL-; N-methyliminopiperidine; N-Methyl-2-piperidinimine; N-methyl-2,3,4,5-tetrahydropyridin-6-amine; SCHEMBL7623417; SCHEMBL10070969; CTK4G8884; DTXSID60303342; ZINC5158898; BDBM50062144; Methyl-piperidin-(2Z)-ylidene-amine; AKOS006349763; MCULE-3924232585; NE60857; NSC-157920; 2,3,4,5-tetrahydro-6-(methylamino)pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
CID 11575808
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911996; SCHEMBL3565001; BDBM50356501
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-Methyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-Methylpiperidin-2-imine; CHEMBL266980; 1-methyl-piperidin-2-ylideneamine; 2-imino-1-methylpiperidine; 2-imino-1 -methylpiperidine; SCHEMBL7622419; DTXSID00498746; BDBM50062141; 1-Methyl-piperidin-(2Z)-ylideneamine; AKOS010784835
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(S)-2-Amino-6-(1-phenyl-1H-imidazol-5-yl)hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485527; BDBM50271592
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[4] | |||
| Compound Name |
[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911997; SCHEMBL3567034; BDBM50356503
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-N'-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)propan-2-yl]ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911979; SCHEMBL13037156; BDBM50356500
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
CID 11523510
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911891; SCHEMBL3561903; BDBM50356513; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-(1H-indol-5-ylmethyl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Methyl-(2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314472; BDBM50117564; (3aR)-N-Methyl-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-(2,3,3a,9b-Tetrahydro-1H-cyclopenta[c]quinolin-4-yl)-hydroxylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85525; BDBM50117572; N-[(3aR)-2,3,3aalpha,9balpha-Tetrahydro-1H-cyclopenta[c]quinoline-4-yl]hydroxylamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
4-((2-Tert-Butyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801484; SCHEMBL4106170; BDBM50348717; 4-[(2-tert-butylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911892; BDBM50356515
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[2-[1,3-Benzodioxol-5-ylmethyl(methyl)amino]ethyl]-2-imidazol-1-yl-6-methylpyrimidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911988; BDBM50356502
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
4-(4'-Amino-1'-ethyl-5'-fluorospiro[piperidine-4,2'-quinazoline]-1-carbonyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221658; BDBM36398; CID24894150; 4-(4'-Amino-1'-ethyl-5'-fluorospiro[piperidine-4,2'-quinazoline]-1-carbonyl)benzonitrile, 5
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[16] | |||
| Compound Name |
3,4-Dimethoxy-2-(methylsulfanylmethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800525; BDBM50418848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112247; ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate; ethyl 4-(2-pyridinylamino]-1-piperidinecarboxylate; SCHEMBL5879617; BDBM50148171; ZINC13580405; AKOS008921980; ethyl 4-(pyridin-2-ylamino)piperidin-1-carboxylate; 4-(Pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1185460; SCHEMBL232295; BDBM50418843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
CID 11631971
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911889; SCHEMBL3566838; BDBM50356511
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-ylmethylamino)-N-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911983; SCHEMBL13037135; BDBM50356498
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[2-(1,3-Benzodioxol-5-ylmethoxy)ethyl]-1-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911989; SCHEMBL3569287; BDBM50356497
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)butan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911981; SCHEMBL20435490; BDBM50356484
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(S)-3-(3-Acetimidoylamino-propoxy)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157074; BDBM50086471; O-[3-(1-Iminoethylamino)propyl]-L-serine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(R)-3-(3-Acetimidoylamino-propylsulfanyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158297; BDBM50086465; S-[3-(1-Iminoethylamino)propyl]-L-cysteine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]ethanimidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217211
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
CID 11703771
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911888; SCHEMBL3562304; BDBM50356510
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
4-Propyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6657; BDBM50062130; 4-Propyl-piperidin-(2Z)-ylideneamine; DA-09530; FT-0751966; 4-propyl-2,3,4,5-tetrahydropyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157846; SCHEMBL5515300; BDBM50086460; 2-amino-4-[2-(1-aminoethylideneamino)ethylsulfonyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
7-Acetimidoylamino-2-amino-heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127739; SCHEMBL8065968; BDBM50030276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N,4,6-Trimethylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112139; (4,6-Dimethyl-pyridin-2-yl)-methyl-amine; 4,6-dimethyl-2-methylaminopyridine; SCHEMBL943294; BDBM50148165; AKOS006351330
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
7,8,9,10,11,11a-Hexahydro-6aH-cyclohepta[c]quinolin-6-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87886; BDBM50117563; (6aR)-7,8,9,10,11,11abeta-Hexahydro-6abetaH-cyclohepta[c]quinoline-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[23] | |||
| Compound Name |
3-[3-(1-Iminoethylamino)propylsulfonyl]-L-alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157190; BDBM50086463; (R)-3-(3-Acetimidoylamino-propane-1-sulfonyl)-2-amino-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4,5-Dimethoxy-2-(methylsulfanylmethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800524; BDBM50418858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[3-[(3-Imidazol-1-yl-1,2,4-thiadiazol-5-yl)-methylamino]propyl]-1,3-benzodioxole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909664; SCHEMBL13037136; BDBM50356514
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-({1H-Imidazo[4,5-c]pyridin-2-ylsulfanyl}methyl)-4-methoxypyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800349; BDBM50418857
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155318; SCHEMBL5512623; BDBM50086469; 2-amino-4-[2-(1-aminoethylideneamino)ethylsulfinyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(S)-Pyrrolidine-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783098; SCHEMBL13070967; (2S)-pyrrolidine-2-carboximidamide; BDBM50346533; ZINC71280869
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(R)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155316; SCHEMBL120694; BDBM50086470; s-[2-(1-iminoethylamino)ethyl]-d-homocysteine; (2R)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911982; SCHEMBL3556339; BDBM50356482
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
CID 11624646
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911887; SCHEMBL3562730; BDBM50356509; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-[(4-methoxyphenyl)methyl]-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
CID 11609610
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911890; SCHEMBL3562106; BDBM50356512; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methyl-N-(pyridin-4-ylmethyl)propane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
3-(2-Butenyl)-5-iminohexahydro-1,4-oxazepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89431; SCHEMBL8552252; BDBM50104657; ((E)-3-But-2-enyl)-[1,4]oxazepan-(5Z)-ylideneamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 108000 nM
|
[27] | |||
| Compound Name |
Benzyl (2S)-5-[[amino(nitramido)methylidene]amino]-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]pentanoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202110
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[13] | |||
| Compound Name |
1-Benzyl-3-(2-isobutyrylamino-4-oxo-6,7-diphenyl-4,6,7,8-tetrahydro-3H-pteridine-5-carbonyl)-pyridinium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321741; PHS-72; BDBM50115130
Click to Show/Hide
|
||||
| Activity |
IC50 = 111100 nM
|
[17] | |||
| Compound Name |
2-[(4-Ethoxyphenyl)methyl]-1-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-nitrobenzimidazole;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215669
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[25] | |||
| Compound Name |
1H-Indazol-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Amino-1H-indazole; 2H-Indazol-7-amine; 7-Aminoindazole; 1H-Indazol-7-ylamine; MFCD00022790; CHEMBL463676; 1H-indazole-7-ylamine; NSC44675; 7-Amino-1H-indazole, 95%; EINECS 244-391-8; NSC 170661; BRN 0003640; 7-AMININDAZOLE; PubChem20891; AI3-52441; 1H-indazol-7-amine, 1; SCHEMBL655480; 7-Amino-1H-indazole, 97%; SCHEMBL13724990; CTK1A4342; CTK3H5138; DTXSID10175718; ZINC112557; ALBB-008668; BCP27106; ANW-44467; BDBM50271275; NSC170661; SBB002545; STK505485; AKOS001438952; AC-3120; MCULE-9439787670; NSC-170661; PB12978; KS-000003I4; AK-27872; SC-22469; SY003896; AB0038001; ST4094305; A4620; CS-0008181; FT-0638121; Y5344; EN300-28544; 3P-091; 43A969; C-1058; 4-25-00-02526 (Beilstein Handbook Reference); W-206629; Q27451589; Z235348069
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[21] | |||
| Compound Name |
2-Amino-propionic acid 2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359988; BDBM50170719
Click to Show/Hide
|
||||
| Activity |
IC50 = 116900 nM
|
[17] | |||
| Compound Name |
7-(2-Methoxyethoxy)-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800531; SCHEMBL5036601; BDBM50418859
Click to Show/Hide
|
||||
| Activity |
IC50 = 123026.88 nM
|
[2] | |||
| Compound Name |
1-[2-(4-Bromophenoxy)ethyl]imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482687; 1-(2-(4-bromophenoxy)ethyl)-1H-imidazole; 1-[2-(4-BROMOPHENOXY)ETHYL]-1H-IMIDAZOLE; SMR000111237; MLS000106861; SCHEMBL8684965; CTK4F4889; DTXSID10357754; HMS2503G09; ZINC431592; BDBM50271550; AKOS009098238; MCULE-5448682586; W-8162; AB00086082-01
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[4] | |||
| Compound Name |
1-(3-(4-Bromophenoxy)propyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484300; Cambridge id 5364823; ZINC3106044; BDBM50271512; MCULE-8380400719; AB00083118-01; SR-01000207174; SR-01000207174-1
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[4] | |||
| Compound Name |
2-Imidazol-1-yl-1-(4-phenylphenyl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482911; SCHEMBL11270111; BDBM50271644; AKOS011036182; 1-Biphenyl-4-yl-2-imidazol-1-yl-ethanol; 2-(1H-Imidazole-1-yl)-1-(1,1'-biphenyl-4-yl)ethanol
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[4] | |||
| Compound Name |
4-Azido-benzoic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317367; BDBM50115125; 4-Azidobenzoic acid (2-amino-4-oxo-3,4-dihydropteridine-6-yl)methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[5] | |||
| Compound Name |
N',N'-Dibenzyl-6-phenylpteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101399; SCHEMBL5514521; BDBM50081589; 4-N,4-N-dibenzyl-6-phenylpteridine-2,4-diamine; N*4*,N*4*-Dibenzyl-6-phenyl-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 129300 nM
|
[17] | |||
| Compound Name |
2-Benzyloxycarbonylamino-propionic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98051; BDBM50115139
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[5] | |||
| Compound Name |
H-Phe-Arg(NO2)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95147; BDBM50059644; L-Nitroarginine-L-phenylalanine ,with 2M of hydrochloric acid
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[13] | |||
| Compound Name |
4-[3-(Trifluoromethyl)-3H-diazirine-3-yl]benzoic acid (2,4-diaminopteridine-6-yl)methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319369
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[5] | |||
| Compound Name |
2-Amino-6-(1-aminoethylideneamino)-5,5-difluorohexanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536253
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[18] | |||
| Compound Name |
6-Methyl-7,8-dihydropterin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Amino-6-Methyl-7,8-Dihydropteridin-4(3h)-One; CHEMBL317940; 2-amino-6-methyl-7,8-dihydro-3H-pteridin-4-one; 2-amino-6-methyl-7,8-dihydro-1H-pteridin-4-one; SCHEMBL7362054; SCHEMBL18898471; CTK4D4761; DTXSID80309649; BDBM50115126; NSC212476; NSC-212476; 2-amino-4-hydroxy-6-methyl-7,8-dihydropteridine; 2-amino-6-methyl-7,8-dihydro-4(3H)-pteridinone; 4(3H)-Pteridinone,2-amino-7,8-dihydro-6-methyl-; Q27454406
Click to Show/Hide
|
||||
| Activity |
IC50 = 145000 nM
|
[5] | |||
| Compound Name |
D-Nitroarginine,methoxy-D-phenylalanine,with 2M of hydrochloric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97782; BDBM50059647
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[13] | |||
| Compound Name |
N-((5S,6R)-5-Amino-6,7-dihydroxy-heptyl)-acetamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164596; BDBM50063301; (2R,3S)-3-Amino-7-[(1-iminoethyl)amino]-1,2-heptanediol
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[28] | |||
| Compound Name |
(S)-2-Amino-8-(1H-imidazol-5-yl)octanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447489; BDBM50271590
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[4] | |||
| Compound Name |
3-Chloro-6-nitro-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Indazole, 3-chloro-6-nitro-; 3-Chloro-6-nitroindazole; 3-chloro-6-nitro-2H-indazole; CHEMBL596229; MFCD00010741; EINECS 256-631-9; NSC 84179; BRN 0013651; 3-Chloro-6-Nitro(1H)Indazole; NSC84179; 4-23-00-01068 (Beilstein Handbook Reference); SCHEMBL2926701; WLN: T56 BMNJ DG HNW; CTK4J2834; 1H-Indazole,3-chloro-6-nitro-; DTXSID40198632; KS-00000DH2; ZINC4877343; ANW-56809; BDBM50304145; NSC-84179; SBB054704; AKOS005072678; FA-0802; MCULE-4697934788; PB24540; 3-CHLORO-6-NITRO (1H)INDAZOLE; AK100069; QC-11264; SY020996; AB0050922; DB-051796; FT-0639913; Z2719; Q-1384; J-512302
Click to Show/Hide
|
||||
| Activity |
IC50 = 158000 nM
|
[21] | |||
| Compound Name |
3-(1H-Imidazol-5-ylmethyl)-L-alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
L-Homohistidine; CHEMBL484914; SCHEMBL1769375; SCHEMBL21689931; DTXSID40487230; ZINC6694499; BDBM50271552; (2S)-2-azaniumyl-4-(1H-imidazol-5-yl)butanoate; (S)-2-amino-4-(1H-imidazol-5-yl)butanoic acid; (2S)-2-amino-4-(1H-imidazol-5-yl)butanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 170000 nM
|
[4] | |||
| Compound Name |
Benzoic acid 2-amino-5-benzoyl-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101216; BDBM50115145
Click to Show/Hide
|
||||
| Activity |
IC50 = 172000 nM
|
[5] | |||
| Compound Name |
1-(2-Biphenyl-4-yl-ethyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL455224; BDBM50271643; 1-[2-(1,1'-Biphenyl-4-yl)ethyl]-1H-imidazole
Click to Show/Hide
|
||||
| Activity |
Ki = 175000 nM
|
[4] | |||
| Compound Name |
Imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Imidazole; Glyoxaline; Imidazol; Iminazole; Miazole; 1,3-Diazole; Glyoxalin; Imutex; 1,3-Diaza-2,4-cyclopentadiene; Pyrro(b)monazole; USAF EK-4733; Pyrro[b]monazole; Formamidine, N,N'-vinylene-; Glioksal [Polish]; Glioksal; Methanimidamide, N,N'-1,2-ethenediyl-; CCRIS 3345; AI3-24703; UNII-7GBN705NH1; NSC 60522; BRN 0103853; N,N'-vinyleneformamidine; MFCD00005183; CHEMBL540; 7GBN705NH1; DTXSID2029616; N,N'-1,2-ethenediylmethanimidamide; Imidazole, 99%; Imidazole, ACS reagent; DSSTox_CID_9616; DSSTox_RID_78788; DSSTox_GSID_29616; Imidazole, 99+%, crystalline; 1H-imidazol; Imidazole (8CI); NSC51860; Imidazole, puriss. p.a., >=99.5% (GC); EINECS 206-019-2; NSC 51860; Immidazole; imidazole-; 1-H-imidazole; Imidazole, Reagent; {Pyrro[b]monazole}; 1,4-cyclopentadiene; Imidazole, ACS grade; ACMC-1CPAG; 1H-Imidazole (9CI); Formamidine,N'-vinylene-; bmse000096; bmse000790; WLN: T5M CNJ; EC 206-019-2; NCIStruc1_001975; NCIStruc2_000693; Imidazole, LR, >=99%; 5-23-04-00191 (Beilstein Handbook Reference); KSC203M9T; MLS001055465; BDBM7882; Imidazole-buffered saline (5X); CTK1A3699; HSDB 8449; 1,3-Diaza-2,4-cyclopentadiene-; Imidazole, ReagentPlus(R), 99%; ZINC901039; Imidazole, for synthesis, 99.5%; BCP26547; HY-D0837; KS-000002NA; NSC60522; Methanimidamide,N'-1,2-ethenediyl-; Tox21_201504; Tox21_303345; ANW-26483; BBL009685; NSC-60522; s6006; SBB040815; STK362967; AKOS000120177; AM82000; CS-5135; DB03366; MCULE-1410806694; Imidazole, BioUltra, >=99.5% (GC); NCGC00090984-01; NCGC00090984-02; NCGC00257344-01; NCGC00259055-01; 2,4-Diazonia-2,4-cyclopentadiene-1-ide; AK-76381; BP-11451; SC-18719; SMR000057825; ST097249; 1,3-Diaza-2,4-cyclopentadiene;Glyoxaline; Imidazole, SAJ special grade, >=99.0%; Imidazole, Vetec(TM) reagent grade, 98%; DB-002018; Imidazole, 0.5M buffer solution, pH 6.0; Imidazole, 0.5M buffer solution, pH 7.0; Imidazole, 0.5M buffer solution, pH 7.5; FT-0627179; FT-0670295; I0001; I0014; I0288; I0290; Imidazole, >=99% (titration), crystalline; Imidazole Zone Refined (number of passes:30); Imidazole, ACS reagent, >=99% (titration); 2519-EP0930075A1; 2519-EP1441224A2; 2519-EP2269977A2; 2519-EP2269978A2; 2519-EP2269985A2; 2519-EP2269990A1; 2519-EP2269991A2; 2519-EP2269992A1; 2519-EP2270002A1; 2519-EP2270006A1; 2519-EP2270008A1; 2519-EP2270010A1; 2519-EP2270011A1; 2519-EP2270014A1; 2519-EP2270015A1; 2519-EP2270113A1; 2519-EP2270505A1; 2519-EP2272509A1; 2519-EP2272510A1; 2519-EP2272516A2; 2519-EP2272517A1; 2519-EP2272537A2; 2519-EP2272813A2; 2519-EP2272817A1; 2519-EP2272825A2; 2519-EP2272827A1; 2519-EP2272828A1; 2519-EP2272832A1; 2519-EP2272838A1; 2519-EP2272839A1; 2519-EP2272840A1; 2519-EP2272841A1; 2519-EP2272848A1; 2519-EP2272849A1; 2519-EP2272935A1; 2519-EP2272972A1; 2519-EP2272973A1; 2519-EP2274983A1; 2519-EP2275102A1; 2519-EP2275395A2; 2519-EP2275401A1; 2519-EP2275404A1; 2519-EP2275409A1; 2519-EP2275411A2; 2519-EP2275412A1; 2519-EP2275413A1; 2519-EP2275414A1; 2519-EP2276085A1; 2519-EP2277848A1; 2519-EP2277858A1; 2519-EP2277872A1; 2519-EP2277880A1; 2519-EP2280000A1; 2519-EP2280005A1; 2519-EP2280009A1; 2519-EP2281563A1; 2519-EP2281813A1; 2519-EP2281815A1; 2519-EP2281818A1; 2519-EP2281819A1; 2519-EP2281824A1; 2519-EP2284149A1; 2519-EP2284150A2; 2519-EP2284151A2; 2519-EP2284152A2; 2519-EP2284153A2; 2519-EP2284155A2; 2519-EP2284156A2; 2519-EP2284157A1; 2519-EP2284164A2; 2519-EP2284169A1; 2519-EP2284920A1; 2519-EP2286812A1; 2519-EP2286915A2; 2519-EP2287140A2; 2519-EP2287148A2; 2519-EP2287150A2; 2519-EP2287161A1; 2519-EP2287162A1; 2519-EP2287165A2; 2519-EP2287166A2; 2519-EP2287167A1; 2519-EP2289868A1; 2519-EP2289871A1; 2519-EP2289884A1; 2519-EP2289890A1; 2519-EP2289894A2; 2519-EP2292586A2; 2519-EP2292590A2; 2519-EP2292592A1; 2519-EP2292593A2; 2519-EP2292596A2; 2519-EP2292597A1; 2519-EP2292604A2; 2519-EP2292606A1; 2519-EP2292610A1; 2519-EP2292611A1; 2519-EP2292612A2; 2519-EP2292613A1; 2519-EP2292617A1; 2519-EP2292619A1; 2519-EP2292620A2; 2519-EP2292621A1; 2519-EP2292630A1; 2519-EP2295401A2; 2519-EP2295402A2; 2519-EP2295406A1; 2519-EP2295414A1; 2519-EP2295415A1; 2519-EP2295419A2; 2519-EP2295421A1; 2519-EP2295426A1; 2519-EP2295427A1; 2519-EP2295429A1; 2519-EP2295432A1; 2519-EP2295433A2; 2519-EP2295434A2; 2519-EP2295550A2; 2519-EP2298731A1; 2519-EP2298732A1; 2519-EP2298742A1; 2519-EP2298743A1; 2519-EP2298744A2; 2519-EP2298755A1; 2519-EP2298763A1; 2519-EP2298766A1; 2519-EP2298767A1; 2519-EP2298770A1; 2519-EP2298772A1; 2519-EP2298774A1; 2519-EP2298776A1; 2519-EP2298778A1; 2519-EP2298783A1; 2519-EP2298828A1; 2519-EP2299509A1; 2519-EP2300438A1; 2519-EP2301534A1; 2519-EP2301536A1; 2519-EP2301538A1; 2519-EP2301912A2; 2519-EP2301913A1; 2519-EP2301914A1; 2519-EP2301916A2; 2519-EP2301918A1; 2519-EP2301921A1; 2519-EP2301926A1; 2519-EP2301929A1; 2519-EP2301930A1; 2519-EP2301931A1; 2519-EP2301932A1; 2519-EP2301933A1; 2519-EP2301934A1; 2519-EP2301935A1; 2519-EP2301937A1; 2519-EP2301940A1; 2519-EP2301983A1; 2519-EP2302003A1; 2519-EP2302015A1; 2519-EP2305219A1; 2519-EP2305250A1; 2519-EP2305637A2; 2519-EP2305640A2; 2519-EP2305643A1; 2519-EP2305648A1; 2519-EP2305651A1; 2519-EP2305652A2; 2519-EP2305657A2; 2519-EP2305658A1; 2519-EP2305659A1; 2519-EP2305668A1; 2519-EP2305674A1; 2519-EP2305676A1; 2519-EP2305682A1; 2519-EP2305689A1; 2519-EP2305695A2; 2519-EP2305696A2; 2519-EP2305697A2; 2519-EP2305698A2; 2519-EP2305769A2; 2519-EP2305808A1; 2519-EP2308510A1; 2519-EP2308562A2; 2519-EP2308812A2; 2519-EP2308832A1; 2519-EP2308833A2; 2519-EP2308839A1; 2519-EP2308840A1; 2519-EP2308848A1; 2519-EP2308852A1; 2519-EP2308854A1; 2519-EP2308855A1; 2519-EP2308861A1; 2519-EP2308863A1; 2519-EP2308867A2; 2519-EP2308868A1; 2519-EP2308869A1; 2519-EP2308870A2; 2519-EP2308872A1; 2519-EP2308873A1; 2519-EP2308874A1; 2519-EP2308877A1; 2519-EP2308879A1; 2519-EP2308880A1; 2519-EP2308883A1; 2519-EP2309584A1; 2519-EP2311451A1; 2519-EP2311455A1; 2519-EP2311464A1; 2519-EP2311796A1; 2519-EP2311797A1; 2519-EP2311798A1; 2519-EP2311799A1; 2519-EP2311802A1; 2519-EP2311803A1; 2519-EP2311815A1; 2519-EP2311818A1; 2519-EP2311820A1; 2519-EP2311823A1; 2519-EP2311825A1; 2519-EP2311826A2; 2519-EP2311827A1; 2519-EP2311830A1; 2519-EP2311841A1; 2519-EP2311842A2; 2519-EP2314295A1; 2519-EP2314558A1; 2519-EP2314574A1; 2519-EP2314575A1; 2519-EP2314582A1; 2519-EP2314583A1; 2519-EP2314587A1; 2519-EP2315303A1; 2519-EP2315502A1; 2519-EP2316450A1; 2519-EP2316452A1; 2519-EP2316459A1; 2519-EP2316470A2; 2519-EP2316829A1; 2519-EP2316831A1; 2519-EP2316832A1; 2519-EP2316833A1; 2519-EP2316836A1; 2519-EP2316905A1; 2519-EP2316906A2; 2519-EP2371810A1; 2519-EP2371811A2; 2519-EP2371812A1; 2519-EP2371831A1; 2519-EP2372017A1; 2519-EP2372804A1; 2519-EP2377847A1; 2519-EP2377848A1; 2519-EP2378585A1; 2519-EP2380874A2; C01589; M-6056; 59390-EP2270011A1; 59390-EP2272846A1; 59390-EP2305808A1; 59390-EP2308852A1; 59390-EP2371806A1; 59390-EP2371812A1; 142240-EP2270010A1; 142240-EP2292593A2; Imidazole buffer Solution, BioUltra, 1 M in H2O; Q328692; J-200340; F2190-0638; Z1245636370; 4286D518-643C-4C69-BCE7-519D073F4992
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| Activity |
Ki = 175000 nM
|
[4] | |||
| Compound Name |
1H-Indazole
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Investigative | Compound Info | ||
| Synonyms |
INDAZOLE; 1H-Benzopyrazole; 2H-indazole; Isoindazole; 2-Azaindole; 1,2-Diazaindene; 1,2-Benzodiazole; 1H-indazol; Benzopyrazole; Azaindole; UNII-7C4VQE5C03; 1,2-Benzopyrazole; MFCD00005691; 7C4VQE5C03; Indazole, 96%; WLN: T56 BMNJ; 1,2-Diazaindene (VAN); EINECS 205-978-4; NSC 26336; indazol; 2-Azoindole; 1-H-indazole; Indazole, 5; Indazole, 6; NSC90357; BENZPYRAZOL; zlchem 598; ACMC-20aixv; Indazole, 98%; PubChem15665; SCHEMBL6295; KSC205O5T; CHEMBL86795; SCHEMBL3056528; SCHEMBL5376344; SCHEMBL5376627; SCHEMBL5376678; SCHEMBL5379372; SCHEMBL5383265; DTXSID4075374; SCHEMBL17515466; BDBM24627; CTK0J2806; CTK1A5759; ZLD0045; ACT05802; BCP27336; NSC26336; ANW-75473; MFCD20483705; NSC-26336; NSC-90357; RW3869; SBB040063; STL371246; ZINC16052862; AKOS000271187; CS-W008689; LS20969; MCULE-6962938625; PB23156; PS-4750; VZ21733; AK-49124; BR-49124; SC-27069; SY001125; AB0015286; DB-024400; A5299; AM20060873; BB 0219702; FT-0607899; FT-0627194; I0278; ST50177678; EN300-44212; KS-00000729; 6945-EP2270010A1; 6945-EP2272517A1; 6945-EP2272813A2; 6945-EP2272828A1; 6945-EP2272832A1; 6945-EP2275395A2; 6945-EP2275401A1; 6945-EP2275404A1; 6945-EP2275412A1; 6945-EP2277858A1; 6945-EP2280000A1; 6945-EP2280012A2; 6945-EP2281563A1; 6945-EP2281818A1; 6945-EP2284157A1; 6945-EP2284920A1; 6945-EP2285783A1; 6945-EP2289890A1; 6945-EP2292586A2; 6945-EP2292592A1; 6945-EP2292604A2; 6945-EP2292611A1; 6945-EP2295412A1; 6945-EP2295413A1; 6945-EP2295429A1; 6945-EP2295432A1; 6945-EP2295433A2; 6945-EP2295550A2; 6945-EP2298738A1; 6945-EP2298767A1; 6945-EP2298770A1; 6945-EP2301923A1; 6945-EP2301937A1; 6945-EP2305250A1; 6945-EP2305648A1; 6945-EP2305651A1; 6945-EP2305675A1; 6945-EP2308510A1; 6945-EP2308562A2; 6945-EP2308840A1; 6945-EP2308848A1; 6945-EP2308854A1; 6945-EP2311824A1; 6945-EP2311825A1; 6945-EP2314575A1; 6945-EP2316459A1; 6945-EP2316470A2; 6945-EP2316832A1; 6945-EP2316833A1; 6945-EP2371811A2; 6945-EP2372804A1; 6945-EP2378585A1; B-1767; 38318-EP2295433A2; 38318-EP2303878A1; 38318-EP2311837A1; 53182-EP2292630A1; 53182-EP2305651A1; 53182-EP2308854A1; 90623-EP2270505A1; 90623-EP2272972A1; 90623-EP2272973A1; 90623-EP2275411A2; 90623-EP2277872A1; 90623-EP2281815A1; 90623-EP2292606A1; 90623-EP2295413A1; 90623-EP2295429A1; 90623-EP2305219A1; 90623-EP2305640A2; AB00376876-02; 103668-EP2300437A1; 271I443; AC-907/25014165; Q417106; J-504679; F0918-7060; F1918-0009; Z276614452
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| Activity |
IC50 = 178000 nM
|
[21] | |||
| Compound Name |
1-(4-(2-Bromophenoxy)butyl)-1H-imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL504297; ZINC2494144; BDBM50271548; MCULE-9996174644; SR-01000207120; SR-01000207120-1
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| Activity |
Ki = 180000 nM
|
[4] | |||
| Compound Name |
N-[3-(2-Amino-5-methoxyphenyl)-3-hydroxypropyl]-N'-methylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800212; J3.549.668H
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| Activity |
IC50 = 180000 nM
|
[29] | |||
| Compound Name |
2-Benzyloxycarbonylamino-3-phenyl-propionic acid 2,4-diamino-pteridin-6-ylmethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101620; BDBM50115166
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| Activity |
IC50 = 180000 nM
|
[5] | |||
| Compound Name |
(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfinyl]-2-methylpropanoic acid;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970153
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| Activity |
IC50 = 181000 nM
|
[15] | |||
| Compound Name |
N-{5-[3-(4-Benzoyl-phenyl)-propionyl]-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-2-yl}-isobutyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL102198; BDBM50115132; N-[4-Oxo-5-[3-(4-benzoylphenyl)propionyl]-3,4,5,6,7,8-hexahydropteridine-2-yl]-2-methylpropanamide
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| Activity |
IC50 = 190000 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-6,7-diphenyl-pteridin-4-yl)-isobutyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99497; BDBM50115129
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| Activity |
IC50 = 192000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 35 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1,2-Dihydro-indazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
1H-Indazol-3-ol; 3-Indazolinone; 7364-25-2; 1H-indazol-3(2H)-one; 100922-96-1; Indazolinone; 3-Hydroxy-1H-indazole; 3-Hydroxyindazole; 1,2-dihydroindazol-3-one; 1,2-Dihydro-3H-indazol-3-one; 3-Oxo-1,2-indazole; 3H-Indazol-3-one, 1,2-dihydro-; 3-Indazolone; 2H-Indazol-3-ol; hydroxyindazole; 2,3-Dihydro-1H-indazol-3-one; NSC 9352; UNII-8E254S9S1R; CCRIS 6800; EINECS 230-904-2; CHEMBL276725; SWEICGMKXPNXNU-UHFFFAOYSA-N; 8E254S9S1R; MFCD00005685; 1H-2-hydroindazol-3-one; benzopyrazolone; 1,2-Dihydro-indazol-3-one; 3-Oxoindazoline
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| Activity |
IC50 > 1000000 nM
|
[21] | |||
| Compound Name |
2,3,3a,4,5,9b-Hexahydro-1H-cyclopenta[c]quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315359; SCHEMBL8266212; BDBM50117548; (3aR)-2,3,3aalpha,4,5,9balpha-Hexahydro-1H-cyclopenta[c]quinoline
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| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfonyl]-2-methylpropanoic acid;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933622
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| Activity |
IC50 = 220000 nM
|
[15] | |||
| Compound Name |
1H-Indazole, 3-bromo-1,5-dinitro-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596341; CTK2I6187; DTXSID70407865; BDBM50304150
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| Activity |
IC50 = 275000 nM
|
[21] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoyl]amino]-3-phenylpropanoate;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204424
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| Activity |
Ki = 290000 nM
|
[13] | |||
| Compound Name |
2,4-Diamino-7,8-dihydro-6H-pteridine-5-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL328636; BDBM50081592; 2,4-Diamino-5,6,7,8-tetrahydropteridine-5-carbaldehyde
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| Activity |
IC50 = 300000 nM
|
[5] | |||
| Compound Name |
3-Ethyl-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
1H-Indazole, 3-ethyl-; 3-ethyl-2H-indazole; CHEMBL595903; ethylindazole; SCHEMBL254885; SCHEMBL19853487; CTK1D2286; DTXSID80485831; BDBM50304146; ZINC24553239; KS-9851
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| Activity |
IC50 = 310000 nM
|
[21] | |||
| Compound Name |
(S)-6-Acetimidoylamino-2-(R)-amino-5-fluoro-hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL170864; BDBM50139795
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| Activity |
IC50 = 311000 nM
|
[18] | |||
| Compound Name |
L-Ornithine, N5-[hydrazino(methylthio)methylene]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL53060; BDBM50077251; (2S)-2-amino-5-{[(1Z)-hydrazino(methylthio)methylene]amino}pentanoic acid; (S)-2-Amino-5-[[(hydrazino)(methylthio)methylene]amino]pentanoic acid
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| Activity |
IC50 = 327000 nM
|
[30] | |||
| Compound Name |
3,5-Dimethylpyrazole-1-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
3,5-dimethylpyrazole-1-carboximidamide; 3,5-Dimethyl-1H-pyrazole-1-carboximidamide; UNII-SVV7S48NBR; SVV7S48NBR; NSC 129885; CHEMBL451397; 1H-Pyrazole-1-carboximidamide,3,5-dimethyl-; 1H-Pyrazole-1-carboximidamide, 3,5-dimethyl-; CHEMBL553974; NSC129885; 1-Guanyl-3,5-dimethylpyrazole nitrate; PubChem14759; 3,5-DIMETHYL-1H-PYRAZOLE-1-CARBOXAMIDIN&; SCHEMBL369236; 1-guanyl-3,5-dimethylpyrazole; 1-amidino-3,5-dimethylpyrazole; 1-guanyl-3,5-dimethyl-pyrazole; 3,5-dimethylpyrazolecarboxamidine; CTK4F0426; DTXSID40177447; ALBB-022815; ZINC4286592; 1-Guanyl-3,5-dimethyl-1H-pyrazole; BDBM50095174; AKOS003634632; 3,5-dimethyl-1-pyrazolecarboximidamide; 3,5-Dimethyl-pyrazole-1-carboxamidine; NSC-129885; AM100544; Pyrazole-1-carboxamidine, 3,5-dimethyl-; ST096356; DB-027490; FT-0709389; R1246; 3,5-Dimethyl-1H-pyrazole-1-carboximidamide #; A816418; 3,5-Dimethyl-pyrazole-1-carboxamidine; hydrochloride; 1H-pyrazole-1-carboximidamide, 3,5-dimethyl-, nitrate (1:1)
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| Activity |
Ki = 350000 nM
|
[4] | |||
| Compound Name |
Methyl (2S)-5-[[amino(nitramido)methylidene]amino]-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]pentanoate;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202109
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| Activity |
Ki = 370000 nM
|
[13] | |||
| Compound Name |
2-Imidazol-1-yl-1-(2-nitrophenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482492; SCHEMBL11239175; BDBM50271595; alpha-(1H-Imidazole-1-yl)-2'-nitroacetophenone; 2-(1H-imidazol-1-yl)-1-(2-nitrophenyl)ethanone
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| Activity |
Ki = 375000 nM
|
[4] | |||
| Compound Name |
3-(6-Amino-2,3,4-trimethoxyphenyl)-1-(3-phenylpropanoyl)-4,5-dihydro-1H-pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2397627; BDBM50492294
Click to Show/Hide
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||||
| Activity |
IC50 = 400000 nM
|
[31] | |||
| Compound Name |
Methyl (2R)-5-[[amino(nitramido)methylidene]amino]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]pentanoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204422
Click to Show/Hide
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||||
| Activity |
Ki = 400000 nM
|
[13] | |||
| Compound Name |
1-Phenylimidazole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
1-Phenyl-1H-imidazole; Phenylimidazole; N-Phenylimidazole; 1H-Imidazole, 1-phenyl-; 1H-Imidazole, phenyl-; MFCD00041204; CHEMBL275066; N-(phenyl)imidazole; PubChem12611; ACMC-20aos8; 1-Phenylimidazole, 97%; SCHEMBL451; 1-Phenyl-1H-imidazole #; MLS001074869; BDBM7886; KS-00000JNG; DTXSID10221885; HMS2231B15; ZINC160340; SBB055861; AKOS006223210; ACN-000837; CS-W004969; MCULE-3399371085; NCGC00247005-01; AK113470; SMR000568399; SY041937; DB-019328; FT-0608260; P2030; ST50823917; Z-0702; 12N-710; 164P989; J-505057; Q27464441; Z440825046
Click to Show/Hide
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||||
| Activity |
Ki = 430000 nM
|
[4] | |||
| Compound Name |
2-Amino-6-(ethoxymethyl)pteridin-4(1H)-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188475; 4(1H)-Pteridinone, 2-amino-6-(ethoxymethyl)-; ACMC-20m77o; SCHEMBL10849935; CTK0G6338; DTXSID20545468; BDBM50170720; 2-Amino-6-ethoxymethyl-3H-pteridin-4-one; 2-AMINO-6-(ETHOXYMETHYL)-1H-PTERIDIN-4-ONE
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[17] | |||
| Compound Name |
[(1R)-1-Acetamido-4-(diaminomethylideneamino)butyl]boronic acid;hydrochloride
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448331; BDBM50071731
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[10] | |||
| Compound Name |
Tert-butyl (2S,3S)-2-amino-3-[2-[[amino(methylsulfanyl)methylidene]amino]ethyl]hexanoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL197055; BDBM50167730; (S)-2-(S)-Amino-3-[2-(2-methyl-isothioureido)-ethyl]-hexanoic acid tert-butyl ester
Click to Show/Hide
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||||
| Activity |
IC50 = 500000 nM
|
[32] | |||
| Compound Name |
[5-(6-Amino-2,3,4-trimethoxyphenyl)-3,4-dihydropyrazol-2-yl]-phenylmethanone
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2397625; BDBM50492295
Click to Show/Hide
|
||||
| Activity |
IC50 = 530000 nM
|
[31] | |||
| Compound Name |
(2R)-2-Amino-3-[(2S)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953808
Click to Show/Hide
|
||||
| Activity |
IC50 = 539000 nM
|
[15] | |||
| Compound Name |
(S)-3-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154895; GW273629; SCHEMBL6381735; BDBM50086464; (2S)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfonyl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 630000 nM
|
[12] | |||
| Compound Name |
2-Methylamino-5,6,7,8-tetrahydro-3H-pteridin-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98655; methyl-tetrahydropterin; BDBM50115174; 2-(methylamino)-5,6,7,8-tetrahydro-1H-pteridin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 650000 nM
|
[5] | |||
| Compound Name |
1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-ethylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798324
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[29] | |||
| Compound Name |
1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-propylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799105
Click to Show/Hide
|
||||
| Activity |
IC50 = 860000 nM
|
[29] | |||
| Compound Name |
1-[5-(2-Amino-4,5-dimethoxyphenyl)-3,4-dihydropyrazol-2-yl]-3-phenylpropan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2397623; BDBM50492296
Click to Show/Hide
|
||||
| Activity |
IC50 = 880000 nM
|
[31] | |||
| Compound Name |
1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-methylthiourea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798072
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[29] | |||
| Compound Name |
1-[3-(2-Aminophenyl)-3-hydroxypropyl]-3-propylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799119
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[29] | |||
| Compound Name |
1-[3-(2-Aminophenyl)-3-hydroxypropyl]-3-methylthiourea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798114
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[29] | |||
| Compound Name |
1H-Indazol-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Aminoindazole; 6-Amino-1H-indazole; 2h-indazol-6-amine; 6-amino-indazole; 1H-indazol-6-ylamine; 6-Aminoimidazole; 1H-indazole-6-ylamine; UNII-KN72RH56SR; KN72RH56SR; MLS000069415; CHEMBL594707; MFCD00005696; Indazol-6-ylamine; SMR000059077; NSC 68265; EINECS 230-177-1; NSC 208700; BRN 0003216; 6-aminoindazol; AI3-52442; 6-Indazolamine; 6-amino indazole; 6-Aminobenzopyrazole; 1H-indazole-6-amine; 1-H-indazol-6-amine; PubChem20593; ACMC-209oab; INDAZOL-6-AMINE; Opera_ID_362; 1H-indazol-6-yl-amine; 6-Aminoindazole, 98%; Oprea1_345131; 4-25-00-02522 (Beilstein Handbook Reference); cid_81423; KSC355E0D; MLS001424157; BIDD:GT0720; SCHEMBL177260; SCHEMBL13423879; CTK2F5201; KS-00000WYN; DTXSID90219962; HMS2052M09; HMS2230F12; HMS3394M09; ACN-S003675; BCP00039; KS-000009RA; NSC16240; NSC68265; ZINC4353646; AC-052; ANW-35745; BDBM50304149; NSC-16240; NSC-68265; NSC208700; SBB002517; STK397879; AKOS000120465; AKOS000268458; AS-8503; CCG-101101; CS-W001975; MCULE-6539781080; NC00351; NSC-208700; PB18392; VZ21734; NCGC00018101-01; NCGC00018101-02; NCGC00018101-03; AK-27923; BR-27923; DA-04152; SC-15649; SY002965; AB0014065; DB-023185; ST4094295; A0798; A4258; A9214; AM20050456; BB 0304022; FT-0620937; FT-0724966; M-3411; Q-9068; 68399-EP2281563A1; 68399-EP2295432A1; 68399-EP2308855A1; 967A120; AE-562/40205851; W-104607; Q27216189; F2158-0745; Z1245635868
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[21] | |||
| Compound Name |
5-Aminoindazole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
1H-Indazol-5-amine; 5-Amino-1H-indazole; 2H-Indazol-5-amine; 1H-Indazole-5-amine; 5-Indazolamine; 1H-Indazole, 5-amino-; 5-AMINOBENZOPYRAZOLE; 1H-Indazol-5-ylamine; 5-Amino-indazole; MFCD00037975; 1~{h}-Indazol-5-Amine; UNII-A5B06TDT72; CHEMBL17551; MLS000069421; A5B06TDT72; Indazol-5-ylamine; 1H-indazole-5-ylamine; SMR000059094; EINECS 242-971-5; NSC 44676; 5aminoindazole; 5-aminoindazol; AI3-52443; 5-aminoazaindole; 5-Aminoisoindazole; PubChem8628; 1-H-indazol-5-amine; 5-Aminoindazole, 97%; Opera_ID_1647; ACMC-1C7ZX; cid_88012; KSC179Q3T; MLS001076528; SCHEMBL117208; DTXSID2066480; CTK0H9839; CTK3H5141; HMS2232B16; HMS3371D15; ZINC152290; ACN-S003653; ALBB-021330; BCP00021; NSC44676; ANW-23596; BBL104266; BDBM50304148; NSC-44676; SBB006576; STL558474; AKOS005203106; AB01685; AC-1055; BCP9000065; CS-W008621; MCULE-2886869012; SB11754; SDCCGMLS-0003169.P003; VP20129; NCGC00018111-01; NCGC00018111-02; NCGC00018111-03; NCGC00018111-04; AK-23803; BR-23803; DA-00909; SC-02100; SY002725; TS-01719; DB-013846; A0797; AM20030258; FT-0620016; FT-0762293; ST50984730; X4400; L-1479; 12836-EP2281563A1; 12836-EP2295412A1; 12836-EP2295413A1; 12836-EP2295432A1; 12836-EP2316831A1; AB00384262-15; AE-562/40222977; W-206426; F2108-0020
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[21] | |||
| Compound Name |
(R)-5-Acetimidoylamino-2-(S)-amino-3-methyl-pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370170; BDBM50167726
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[32] | |||
| Compound Name |
L-Ornithine, N5-(hydrazinothioxomethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57111; BDBM50077252; (S)-2-Amino-5-[hydrazino(thiocarbonyl)amino]pentanoic acid; (2S)-2-amino-5-[(hydrazinocarbonothioyl)amino]pentanoic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 1621000 nM
|
[30] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416103
Click to Show/Hide
|
||||
| Activity |
IC50 > 1850000 nM
|
[33] | |||
| Compound Name |
(2S)-2-Amino-5-[carbamoyl(methyl)amino]pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL408088; SCHEMBL12493127; BDBM50375815
Click to Show/Hide
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||||
| Activity |
IC50 = 7900000 nM
|
[34] | |||
| Compound Name |
1-(Prop-2-ynyl)guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-prop-2-ynylguanidine; propargylguanidine; 1-Propargylguanidine; CHEMBL1159994; ZINC29238553; AKOS009145512; MCULE-4578514197; BCB03_000457; DA-03407; FT-0733328; PK04_107207
Click to Show/Hide
|
||||
| Activity |
Ki = 12000000 nM
|
[35] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of nitric oxide synthase by benzoxazolones. Bioorg Med Chem Lett. 1997 Nov 18;7(22):2887-92. | ||||
| REF 2 | Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4228-32. | ||||
| REF 3 | Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1975-8. | ||||
| REF 4 | Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase. Bioorg Med Chem. 2008 Jun 1;16(11):6193-206. | ||||
| REF 5 | Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. J Med Chem. 2002 Jul 4;45(14):2923-41. | ||||
| REF 6 | Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. | ||||
| REF 7 | Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. | ||||
| REF 8 | N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J Med Chem. 1998 Jul 16;41(15):2858-71. | ||||
| REF 9 | 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. | ||||
| REF 10 | Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2573-6. | ||||
| REF 11 | Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. J Med Chem. 2000 Jul 27;43(15):2938-45. | ||||
| REF 12 | Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett. 2000 Mar 20;10(6):597-600. | ||||
| REF 13 | Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. J Med Chem. 1997 Aug 29;40(18):2813-7. | ||||
| REF 14 | Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem. 1997 Jun 6;40(12):1901-5. | ||||
| REF 15 | US patent application no. 20020111493A1, Amidino compounds useful as nitric oxide synthase inhibitors | ||||
| REF 16 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. | ||||
| REF 17 | Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem. 2005 Jul 28;48(15):4783-92. | ||||
| REF 18 | 5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors. J Med Chem. 2004 Feb 12;47(4):900-6. | ||||
| REF 19 | 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J Med Chem. 2004 Jun 3;47(12):3320-3. | ||||
| REF 20 | Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6888-94. | ||||
| REF 21 | Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. | ||||
| REF 22 | Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101. | ||||
| REF 23 | Dihydroquinolines as novel n-NOS inhibitors. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2561-4. | ||||
| REF 24 | Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models. J Med Chem. 2010 Nov 11;53(21):7739-55. | ||||
| REF 25 | NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with -Opioid Agonist Activity. ACS Med Chem Lett. 2012 Jan 30;3(3):227-31. | ||||
| REF 26 | Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):3037-40. | ||||
| REF 27 | Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. | ||||
| REF 28 | Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase. J Med Chem. 1998 Mar 12;41(6):775-7. | ||||
| REF 29 | N,N'-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase. Medchemcomm. 2016;7:667-78. | ||||
| REF 30 | Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase. J Med Chem. 1999 May 20;42(10):1842-8. | ||||
| REF 31 | Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group. Bioorg Med Chem. 2013 Jul 15;21(14):4132-42. | ||||
| REF 32 | Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2881-5. | ||||
| REF 33 | Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. J Med Chem. 2002 Apr 11;45(8):1686-9. | ||||
| REF 34 | N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system. Bioorg Med Chem. 2008 Mar 1;16(5):2305-12. | ||||
| REF 35 | Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine. Bioorg Med Chem Lett. 1997 Jun 3;7(11):1449-54. | ||||
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