Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28893 | Target Info | |||
| Target Name | Muscarinic acetylcholine receptor M1 (CHRM1) | ||||
| Synonyms |
M1 receptor
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| Target Type | Successful Target | ||||
| Gene Name | CHRM1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 89 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Carbachol
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|
Approved | Compound Info | ||
| Synonyms |
Carbach; Carbacholin; Carbacholine; Carbacholinum; Carbacholum; Carbacol; Carbacolina; Carbacolo; Carbamiotin; Carbamoylcholine; Carbastat; Carbochol; Carbocholin; Carbocholine; Carbyl; Carcholin; Coletyl; Doryl; Jestryl; Karbachol; Lentin; Lentine; Miostat; Moryl; Rilentol; Vasoperif; CARBACHOL CHLORIDE; Carbachol hydrochloride; Carbacholine chloride; Carbacholini chloridum; Carbacholinium chloratum; Carbacholum chloratum; Carbacolo [DCIT]; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamoylcholine chloride; Carbamylcholine chloride; Choline carbamate chloride; Choline chloride carbamate; Choline chlorine carbamate; Isopto Carbachol; Karbachol [Czech]; Karbamoylcholin chlorid; Karbamoylcholin chlorid [Czech]; Lentine [French]; Mistura C; C 4382; TL 457; C-1770; Carbacholum [INN-Latin]; Carbacol [INN-Spanish]; Carbamic acid, ester with choline chloride; Carbamoylcholine-hydrochloride; Carbastat (TN); Carboptic (TN); Choline chloride, carbamate; Doryl (VAN); Doryl (pharmaceutical); Gamma-Carbamoyl choline chloride; Isopto Carbachol (TN); Miostat (TN); Carbachol [INN:BAN:JAN]; Choline, chloride carbamate(ester); Choline, chloride, carbamate; P. V. Carbachol; Carbachol (JAN/USP/INN); Choline, chloride, carbamate, hydrochloride; Ethanaminium, 2-(aminocarbonyl)oxy-N,N,N-trimethyl-, chloride; Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride (1:1); (2-Carbamoyloxy-ethyl)-trimethyl-ammonium; (2-Carbamoyloxy-ethyl)-trimethyl-ammonium(Carbachol); (2-Carbamoyloxyethyl)trimethylammonium chloride; (2-Hydroxyethyl)trimethyl ammonium chloride carbamate; (2-Hydroxyethyl)trimethylammonium chloride carbamate; (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride; 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride; 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride; 2-carbamoyloxyethyl(trimethyl)azanium chloride
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| Activity |
Ki = 63000 nM
|
[1] | |||
| Compound Name |
Acetylcholine
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Approved | Compound Info | ||
| Synonyms |
acetylcholine; Choline acetate; O-Acetylcholine; Acetyl choline ion; Acetylcholinum; 51-84-3; (2-Acetoxyethyl)trimethylammonium; Acetyl choline cation; Choline acetate (ester); 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ach; Azetylcholin; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; UNII-N9YNS0M02X; BRN 1764436; CHEBI:15355; Bromoacetylcholine; EINECS 200-128-9; CHEMBL667; N9YNS0M02X; [2-(acetyloxy)ethyl]trimethylazanium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- (9CI); 2-acetyloxyethyl-trimethylazanium; [3H]acetylcholine; Miochol; Miochol-e
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| Activity |
EC50 = 100000 nM
|
[2] | |||
| Compound Name |
6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468176; BDBM50261729
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
8-Hydroxy-2-(dimethylamino)-1,2,3,4-tetrahydronaphthalene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146953; SCHEMBL8891132; BDBM50246626; 7-(dimethylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391353; BDBM50435313
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
(2R)-2-(Furan-2-yl)-1,1-dimethylpyrrolidin-1-ium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL527880
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| Activity |
Ki = 51286.14 nM
|
[5] | |||
| Compound Name |
2-(3-Methoxyphenyl)ethyl-trimethylazanium;formate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091934; BDBM50246711
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| Activity |
Ki = 52000 nM
|
[1] | |||
| Compound Name |
(2R)-1,1-Dimethyl-2-[(2S,4R)-2-methyl-1,3-dioxolan-4-yl]pyrrolidin-1-ium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259131; BDBM50478147
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| Activity |
Ki = 52480.75 nM
|
[6] | |||
| Compound Name |
3-(4-Imidazol-1-ylbutoxy)-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL272468; BDBM50423608
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| Activity |
IC50 = 52480.75 nM
|
[7] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL168223; BDBM50474495
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| Activity |
Ki = 53703.18 nM
|
[8] | |||
| Compound Name |
2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391352; BDBM50435314
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| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
1-[3-[4-[9-[[4-(1-Methyl-1,2,5,6-tetrahydropyridine-3-yl)-1,2,5-thiadiazole-3-yl]oxy]nonyl]piperidino]propyl]-3,4-dihydro-2(1H)-quinolinone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354069; BDBM50030224
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| Activity |
EC50 = 61659.5 nM
|
[9] | |||
| Compound Name |
(2S)-2-(Furan-2-yl)pyrrolidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL451335; Pyrrolidine, 2-(2-furanyl)-, (2S)-; SCHEMBL6181015; ZINC2582574; BDBM50412428
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| Activity |
Ki = 63095.73 nM
|
[5] | |||
| Compound Name |
Trimethyl-[[(2R,6S)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594803
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| Activity |
Ki = 67608.3 nM
|
[10] | |||
| Compound Name |
Trimethyl-[[(2S,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227429; BDBM50003016
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| Activity |
Ki = 74131.02 nM
|
[11] | |||
| Compound Name |
Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2R)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461502; BDBM50412425; ZINC40861610
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| Activity |
Ki = 77624.71 nM
|
[5] | |||
| Compound Name |
5-(4-Butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101054; Pyridine, 3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methyl-; ACMC-20mubh; SCHEMBL6906658; CTK0F5222; DTXSID40567268; BDBM50003351; L004167; 1,2,5,6-Tetrahydro-1-methyl-3-[4-butoxy-1,2,5-thiadiazol-3-yl]pyridine; 3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyridine; 3-butoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole; 5-(4-Butoxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine
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| Activity |
IC50 = 77624.71 nM
|
[7] | |||
| Compound Name |
4-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]butan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL255793; BDBM50423617
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| Activity |
IC50 = 77624.71 nM
|
[7] | |||
| Compound Name |
1-Aza-bicyclo[2.2.1]heptan-3-one O-methyl-oxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL85678; BDBM50065215; L005676
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| Activity |
IC50 = 85050 nM
|
[12] | |||
| Compound Name |
(2R,3R,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093084; BDBM50475678
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| Activity |
Ki = 93325.43 nM
|
[13] | |||
| Compound Name |
(2R,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541424; BDBM50478149
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| Activity |
Ki = 93325.43 nM
|
[6] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595022
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| Activity |
Ki = 95499.26 nM
|
[10] | |||
| Compound Name |
N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391367; SCHEMBL975152; BDBM50435331; AKOS032990511
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441756
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
6,7,8,9-Tetrahydro-[1,2,5]thiadiazolo[3,4-h]isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL15936; [1,2,5]Thiadiazolo[3,4-h]isoquinoline, 6,7,8,9-tetrahydro; SCHEMBL7810242; BDBM50062157; 6,7,8,9-Tetrahydro-2-thia-1,3,8-triaza-cyclopenta[a]naphthalene
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| Activity |
IC50 = 100000 nM
|
[15] | |||
| Compound Name |
Ethyl 1-[2-(4-methoxyphenyl)ethyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311977; BDBM50426228
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309717
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| Activity |
Ki ~ 100000 nM
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[17] | |||
| Compound Name |
(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441760
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| Activity |
Ki ~ 100000 nM
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[14] | |||
| Compound Name |
N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391366; SCHEMBL974224; BDBM50435332
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(2S)-1-(4-Methoxyphenyl)propan-2-yl] 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312390; BDBM50426273
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| Activity |
Ki ~ 100000 nM
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[16] | |||
| Compound Name |
2-(4-Methoxyphenyl)ethyl 1-[(4-methoxyphenyl)methyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312385; BDBM50426257
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| Activity |
Ki ~ 100000 nM
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[16] | |||
| Compound Name |
(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441750
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| Activity |
Ki ~ 100000 nM
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[14] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441757
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| Activity |
Ki ~ 100000 nM
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[14] | |||
| Compound Name |
Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441752
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 1-butyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312363; BDBM50426251
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| Activity |
Ki ~ 100000 nM
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[16] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312380; BDBM50426262
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| Activity |
Ki ~ 100000 nM
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[16] | |||
| Compound Name |
(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441751
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL500313; BDBM50256181
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| Activity |
Ki ~ 100000 nM
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[14] | |||
| Compound Name |
Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309715
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| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593864
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 4-(3-methoxyphenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312356; BDBM50426231
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| Activity |
Ki ~ 100000 nM
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[16] | |||
| Compound Name |
Esaprazole
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Investigative | Compound Info | ||
| Synonyms |
N-Cyclohexyl-2-piperazin-1-yl-acetamide; Exaprazole; N-cyclohexyl-2-piperazin-1-ylacetamide; N-cyclohexyl-2-(piperazin-1-yl)acetamide; N-Cyclohexyl-1-piperazineacetamide; UNII-38QSU0IB5L; 1-Piperazineacetamide, N-cyclohexyl-; Hexaprazol; 38QSU0IB5L; 1-Piperazineacetamide,N-cyclohexyl-; MFCD00865680; hexaprazole; NCGC00160434-01; DSSTox_CID_26147; DSSTox_RID_81379; DSSTox_GSID_46147; Esaprazole [INN]; Esaprazola; Esaprazolum; Esaprazolum [INN-Latin]; Esaprazola [INN-Spanish]; BRN 0785765; Prazol; N-cyclohexyl-2-piperazin-1-ylacetamide dihydrochloride; 5-23-02-00264 (Beilstein Handbook Reference); MLS004754470; SCHEMBL931007; CHEMBL1983100; DTXSID0046147; CTK5C0914; ALBB-013043; Tox21_111808; 7294AE; BDBM50435343; ZINC19737386; AKOS000209735; Tox21_111808_1; MCULE-8782683340; NE28840; N-cyclohexyl-2-(1-piperazinyl)acetamide; NCGC00160434-02; AS-44244; SMR002529465; n-(cyclohexyl-2-piperazin-1-yl)-acetamide; FT-0678584; EN300-68725; AE-641/00334033; AE-641/30178021; SR-01000883686; SR-01000883686-1; 1-piperazineacetamide, N-cyclohexyl-, dihydrochloride; BRD-K92426617-001-01-4; Q27256807; Z234896745
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
N-Isopropyl-1-piperazineacetamide
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Investigative | Compound Info | ||
| Synonyms |
n-isopropyl-2-(piperazin-1-yl)acetamide; N-isopropyl-2-piperazin-1-ylacetamide; 2-piperazin-1-yl-N-propan-2-ylacetamide; 2-(piperazin-1-yl)-N-(propan-2-yl)acetamide; CHEMBL2391356; 1-Piperazineacetamide, N-(1-methylethyl)-; N-(methylethyl)-2-piperazinylacetamide; EINECS 254-676-9; NSC379438; SCHEMBL255190; CTK4I2048; KS-00003TBM; DTXSID10192925; N-isopropyl-2-piperazinoacetamide; 2-piperazinyl-N-isopropylacetamide; N-isopropyl-1-piperazine acetamide; piperazinoacetic acid isopropylamide; ALBB-006203; 2503AE; BDBM50435342; MFCD00005969; SBB027314; STK501255; ZINC19942920; AKOS000264275; MCULE-4117297184; NSC-379438; VP70271; N-Isopropyl-1-piperazineacetamide, 95%; TS-02582; 1-Piperazineacetamide,N-(1-methylethyl)-; N-Isopropyl-2-(1-piperazinyl)acetamide #; DB-049493; BB 0259628; FT-0639584; ST45024241; EN300-18601; W-6183
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441754; SCHEMBL21541688; (5S)-5-[(dimethylamino)methyl]-1,3-oxazolidin-2-one
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Trimethyl-[[(2R,5R)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594376
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
2,3-Dihydro-1-benzofuran-5-ylmethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312365; BDBM50426249
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441758
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL279105; BDBM50062158; 1,4-Dimethyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 4-(2-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312355; BDBM50426232
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Ethyl 1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311978; BDBM50426227
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
5-(1-Azabicyclo[2.2.1]heptan-3-yl)-1,2,4-oxadiazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314737; 3-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane; 1,2,4-Oxadiazol-3-amine,5-(1-azabicyclo[2.2.1]hept-3-yl)-; 3-(5-(3-Aminoox))abch; ACMC-20c7cn; SCHEMBL9369455; CTK4A8876; DTXSID80921481; BDBM50280565; L001896; L-670207; 1,2,4-Oxadiazol-3-amine, 5-(1-azabicyclo(2.2.1)hept-3-yl)-; 5-(1-Aza-bicyclo[2.2.1]hept-3-yl)-[1,2,4]oxadiazol-3-ylamine; 5-(1-Azabicyclo[2.2.1]heptan-3-yl)-1,2,4-oxadiazol-3(2H)-imine
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[12] | |||
| Compound Name |
[(2R,6R)-6-Ethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042401
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312351; BDBM50426237
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391382; SCHEMBL974621; BDBM50435316
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(2,4,6-Trimethylphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312381; BDBM50426261
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Trimethyl-[[(2R)-5,5,6,6-tetramethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593861
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 4-(2-methoxyphenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312357; BDBM50426230
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404557
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
[(2R,5R,6S)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608985
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391374; BDBM50435324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(2R)-1,4-Dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309718
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Ethyl 1-[1-(2,6-dimethylbenzoyl)piperidin-4-yl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311980; BDBM50426225
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Ethyl 1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311979; BDBM50426226
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Trimethyl-[[(2R,5S)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593443
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Ethyl 1-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311982; BDBM50426223
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(4-Methoxyphenyl)ethyl 1-butyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312360; BDBM50426254
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312345; BDBM50426279
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 4-phenyl-1-propyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312362; BDBM50426252
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(2-Methoxy-2-phenylethyl) 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312348; BDBM50426240
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220553; BDBM50194316; (5R,2''S)-5[1''-methylpyrrolidin-2''-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359597
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441753
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 4-phenyl-1-(2-phenylethyl)-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311976; BDBM50426229
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(4-Methoxyphenyl)ethyl 4-phenyl-1-propyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312359; BDBM50426255
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441759
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594802
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(4-Methylsulfonylphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312375; BDBM50426267
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391368; SCHEMBL976125; BDBM50435329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441755
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 1-[1-(2,6-dichlorobenzoyl)piperidin-4-yl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311981; BDBM50426224
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441761
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
[(2R,5R,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593871
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391357; SCHEMBL1024404; BDBM50435341
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[4] | |||
| Compound Name |
2-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406570; BDBM50423612
Click to Show/Hide
|
||||
| Activity |
IC50 = 109647.82 nM
|
[7] | |||
| Compound Name |
5-[[(E)-1-Azabicyclo[2.2.2]octan-3-ylmethylideneamino]oxymethyl]-1,2-oxazole-3-carbonitrile;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99244
Click to Show/Hide
|
||||
| Activity |
IC50 = 132700 nM
|
[19] | |||
| Compound Name |
Pyrrolidine, 2-(5-methyl-2-furanyl)-, (2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458416; ZINC4234800; BDBM50412426; AKOS006329069
Click to Show/Hide
|
||||
| Activity |
Ki = 154881.66 nM
|
[5] | |||
| Compound Name |
Flaxedil
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Triethylgallamine; UNII-VYJ027LZ05; Gallamine triiodoethylate; CHEMBL360055; VYJ027LZ05; Benzkurin; Gallamine iodide; Benzcurine iodide; Gallamin triethiodide; Gallamone triethiodide; Triiodoethylate de gallamine; 2,2',2''-(benzene-1,2,3-triyltris(oxy))tris(N,N,N-triethylethan-1-aminium); NCGC00163245-01; Lopac G-8134; Gallamine Triethiiodide; Spectrum_000823; Prestwick0_000157; Prestwick1_000157; Prestwick2_000157; Prestwick3_000157; Spectrum2_001078; Spectrum3_000439; Spectrum4_000561; Spectrum5_000748; Lopac G 8134; Lopac-G-8134; Lopac0_000550; BSPBio_000294; BSPBio_002058; GTPL356; KBioGR_000962; KBioSS_001303; DivK1c_000650; SPBio_001096; SPBio_002233; BPBio1_000324; DTXSID5048392; SCHEMBL12638600; KBio1_000650; KBio2_001303; KBio2_003871; KBio2_006439; KBio3_001278; NINDS_000650; HMS2089F21; ZINC3830882; 2-[2,3-bis[2-(triethylazaniumyl)ethoxy]phenoxy]ethyl-triethylazanium; BDBM50149891; Ethanaminium, 2,2',2''-(benzene-1,2,3-triyltris(oxy))tris(N,N,N-triethyl-; CCG-204640; MCULE-9106832696; IDI1_000650; NCGC00015482-01; NCGC00015482-02; NCGC00015482-03; NCGC00015482-04; NCGC00015482-05; NCGC00015482-16; NCGC00162183-01; SBI-0050533.P004; AB00053799; AB00053799-08; AB00053799-09; AB00053799_10; AB00053799_11; L001056; Q27077765; 2-[2,3-bis[2-(triethylammonio)ethoxy]phenoxy]ethyl-triethylammonium; 2-[2,6-bis(2-triethylazaniumylethoxy)phenoxy]ethyl-triethylazanium; 2,2',2''-(1,2,3-Benzenetriyltrisoxy)tris(N,N,N-triethylethanaminium); 2,2',2''-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium); 2,2'',2''''-[1,2,3-BENZENE-TRIYLTRIS(OXY)]TRIS[N,N,N-TRIETHYLETHANAMINIUM]
Click to Show/Hide
|
||||
| Activity |
EC50 = 170000 nM
|
[20] | |||
| Compound Name |
2-(Furan-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(2-furyl)pyrrolidine; 2-Furan-2-yl-pyrrolidine; Pyrrolidine, 2-(2-furyl)-; CHEMBL461087; Pyrrolidine, 2-(2-furanyl)-; 2-pyrrolidin-2-ylfuran; 2-(2-Furanyl)pyrrolidine; 2-(2-Furyl)pyrrolidine; 2-(Furan-2-yl)pyrrolidine; 2-(2-Furanyl)pyrrolidine; Oprea1_525509; SCHEMBL2349663; (?)-2-(2-Furanyl)pyrrolidine; CTK5G7373; KS-00001OWO; (RS)-2-furan-2-yl-pyrrolidine; DTXSID60394917; (+/-)-2-(2-Furanyl)pyrrolidine; BBL020479; BDBM50412416; MFCD02663415; SBB025605; STK134526; AKOS005168094; MCULE-6604305404; PS-3493; VP60214; (S)-5-AMINOMETHYLPYRROLIDIN-2-ONE; DB-019508; BB 0249484; FT-0642156; ST45134019; EN300-74367; A26468; B-1535; 086F898; Z1335657438
Click to Show/Hide
|
||||
| Activity |
Ki = 177827.94 nM
|
[5] | |||
| Compound Name |
5-[[(E)-1-Azabicyclo[2.2.1]heptan-3-ylmethylideneamino]oxymethyl]-1,2-oxazole-3-carbonitrile;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97716
Click to Show/Hide
|
||||
| Activity |
IC50 = 189500 nM
|
[19] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 36 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[3-[4-(9-Hydroxynonyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354075; BDBM50030247
Click to Show/Hide
|
||||
| Activity |
EC50 = 245470.89 nM
|
[9] | |||
| Compound Name |
6-Acetoxy-8-methyl-8-azonia-bicyclo[3.2.1]octane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294273; BDBM50064612; Acetic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 281838.29 nM
|
[6] | |||
| Compound Name |
Ethyl (1S,5R)-3-[2-[(3-fluoro-4-methylbenzoyl)amino]ethylamino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024324; BDBM50382151
Click to Show/Hide
|
||||
| Activity |
EC50 = 470000 nM
|
[21] | |||
| Compound Name |
Acid red 52
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
C.I. Acid Red 52; Acid Rhodamine B; Amido Rhodamine B; Acid Red XB; Food Red 106; Xylene Red B; Kiton Rhodamine B; Xylene Red; Lissamine rhodamine B; UNII-821LWZ3R6R; Sulforhodamine B sodium salt; C.I. 45100; 821LWZ3R6R; Acid Red 52;Kiton Red 620; Sulforhodamine B (sodium salt); Fenazo Pink XXB; Solar Rhodamine B; Amacid Rhodamine B; Erio Acid Red XB; Erio Acid Red XBC; Pontacyl Brilliant Pink; MLS001195097; Brilliant Acid Rhodamine B; Red No. 106; Red 106; Aizen Food Red No. 106; Brilliant Superlan Rhodamine B; CCRIS 2446; Brilliant Superlan Rhodamine 2B; MFCD00010180; SMR000554424; EINECS 222-529-8; CI 45100; Kiton Red S; MLS003878226; C27H29N2NaO7S2; CHEMBL1306565; DTXSID7021235; SCHEMBL16593265; HMS2883G10; AKOS000283079; AKOS015903434; AK176284; A0600; F0143; FT-0621855; ST51016151; C20348; J-020000; sodium 4-[3,6-bis(diethylamino)xanthenium-9-yl]benzene-1,3-disulfonate; sodium;4-[3,6-bis(diethylamino)xanthen-10-ium-9-yl]benzene-1,3-disulfonate
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[20] | |||
| Compound Name |
Ethyl (4aR,8aS)-1-(2-benzamidoethyl)-2,3,4,4a,5,7,8,8a-octahydro-1,6-naphthyridine-6-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024328; BDBM50382162
Click to Show/Hide
|
||||
| Activity |
EC50 = 1200000 nM
|
[21] | |||
| Compound Name |
Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1624037; BDBM43822; cid_25010775; ML071; ZINC64696513; NCGC00386615-02
Click to Show/Hide
|
||||
| Activity |
EC50 = 1600000 nM
|
[21] | |||
| Compound Name |
Rac-N,N-dimethyl-2-(3-(1-(thiazol-2-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092767; SCHEMBL4849256; BDBM50314283; N,N-dimethyl-2-[3-[1-(1,3-thiazol-2-yl)ethyl]-1-benzothiophen-2-yl]ethanamine
Click to Show/Hide
|
||||
| Activity |
Ki = 2072000 nM
|
[22] | |||
| Compound Name |
Ethyl (4aS,8aS)-1-(2-benzamidoethyl)-2,3,4,4a,5,7,8,8a-octahydro-1,6-naphthyridine-6-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024327; BDBM50382152
Click to Show/Hide
|
||||
| Activity |
EC50 = 3200000 nM
|
[21] | |||
| Compound Name |
Ethyl (1S,5R)-6-[2-[(2-methylbenzoyl)amino]ethylamino]-3-azabicyclo[3.1.0]hexane-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024326; BDBM50382153
Click to Show/Hide
|
||||
| Activity |
EC50 = 4100000 nM
|
[21] | |||
| Compound Name |
(-)-(R)-N,N-Dimethyl-2-(3-(1-(thiazol-4-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091782; SCHEMBL4842436; BDBM50314284; N,N-dimethyl-2-[3-[(1R)-1-(1,3-thiazol-4-yl)ethyl]-1-benzothiophen-2-yl]ethanamine
Click to Show/Hide
|
||||
| Activity |
Ki = 4759000 nM
|
[22] | |||
| Compound Name |
Methyl 4-(2-benzamidoethylamino)bicyclo[2.2.2]octane-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024325; BDBM50382154
Click to Show/Hide
|
||||
| Activity |
EC50 = 6200000 nM
|
[21] | |||
| Compound Name |
(-)-(R)-2-(3-(1-(1H-Pyrazol-1-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093058; BDBM50314287
Click to Show/Hide
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||||
| Activity |
Ki > 10000000 nM
|
[22] | |||
| Compound Name |
(-)-(R)-N,N-Dimethyl-2-(3-(1-(thiazol-5-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092118; SCHEMBL4851219; BDBM50314285; N,N-dimethyl-2-[3-[(1R)-1-(1,3-thiazol-5-yl)ethyl]-1-benzothiophen-2-yl]ethanamine
Click to Show/Hide
|
||||
| Activity |
Ki > 10000000 nM
|
[22] | |||
| Compound Name |
4-[4-(4-Hydroxy-4,4-diphenylbutyl)piperazin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404866
Click to Show/Hide
|
||||
| Activity |
Ki = 1.17E+12 nM
|
[23] | |||
| Compound Name |
Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227378; BDBM50003015
Click to Show/Hide
|
||||
| Activity |
EC50 = 1.26E+12 nM
|
[24] | |||
| Compound Name |
Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228144; BDBM50003014
Click to Show/Hide
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||||
| Activity |
EC50 = 2.04E+12 nM
|
[24] | |||
| Compound Name |
1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403029
Click to Show/Hide
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||||
| Activity |
Ki = 2.75E+12 nM
|
[23] | |||
| Compound Name |
4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255692
Click to Show/Hide
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||||
| Activity |
Ki = 4.07E+12 nM
|
[23] | |||
| Compound Name |
(4-Hydroxy-4,4-diphenylbutyl)-[2-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]ethyl]-dimethylazanium;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257586
Click to Show/Hide
|
||||
| Activity |
Ki = 3.80E+13 nM
|
[23] | |||
| Compound Name |
4-(1-Methyl-4-phenylpiperazin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257547
Click to Show/Hide
|
||||
| Activity |
Ki = 5.75E+13 nM
|
[23] | |||
| Compound Name |
4-[4-(1,1-Dimethylpiperidin-1-ium-4-yl)-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257804
Click to Show/Hide
|
||||
| Activity |
Ki = 1.20E+14 nM
|
[23] | |||
| Compound Name |
Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390842
Click to Show/Hide
|
||||
| Activity |
EC50 = 1.20E+14 nM
|
[24] | |||
| Compound Name |
4-(4-Methylpiperazin-1-yl)-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258161
Click to Show/Hide
|
||||
| Activity |
Ki = 1.29E+14 nM
|
[23] | |||
| Compound Name |
(4-Hydroxy-4,4-diphenylbutyl)-[3-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]propyl]-dimethylazanium;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403592
Click to Show/Hide
|
||||
| Activity |
Ki = 1.38E+14 nM
|
[23] | |||
| Compound Name |
4-[4-(4-Hydroxy-4,4-diphenylbutyl)-4-methylpiperazin-4-ium-1-yl]-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402282
Click to Show/Hide
|
||||
| Activity |
Ki = 1.41E+14 nM
|
[23] | |||
| Compound Name |
4-[4-(1-Methylpiperidin-4-yl)piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257174
Click to Show/Hide
|
||||
| Activity |
Ki = 1.74E+14 nM
|
[23] | |||
| Compound Name |
Xanomeline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole; LY 246708; UNII-9ORI6L73CJ; LY-246708; 9ORI6L73CJ; CHEMBL21536; 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE; 141064-23-5 (oxalate); 3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole; 5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine; Xanomeline [USAN:INN]; Pyridine, 3-(4-(hexyloxy)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methyl-; Pyridine,3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-; C14H23N3OS; LY246708; Lumeron; Memcor; Hexyloxy-TZTP; Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-; Xanomeline (USAN); ACMC-20aga8; GTPL57; 3-(4-(Hexyloxy)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine; SCHEMBL121046; CTK4B7643; DTXSID60157286; BCP31492; KS-00000EZ0; ZINC1532358; ANW-72030; BDBM50003359; MFCD00867179; AKOS016007489; DB15357; SB18821; VP14766; NNC-11-0232; AK-57746; DS-15663; FT-0602214; C11767; D06330; L000694; Q8042940; LY-246708; LY246708; LY 246708; 3-(4-hexoxy-1,2,5-thiadiazol-3-yl)-1-methyl-5,6-dihydro-2H-pyridine; 3-(4-hexyloxy-1 ,2,5-thiadiazol-3-yl)-1 ,2,5,6-tetrahydro-1-methyl-pyridine
Click to Show/Hide
|
||||
| Activity |
Ki = 2.51E+14 nM
|
[25] | |||
| Compound Name |
4-(4,4-Dimethylpiperazin-4-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436850
Click to Show/Hide
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||||
| Activity |
Ki = 3.39E+14 nM
|
[23] | |||
| Compound Name |
Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD 102807; CHEMBL59898; LSM-1888; SCHEMBL5071655; CTK8G2286; DTXSID20407355; HMS3268M09; HMS3412B04; HMS3676B04; BDBM50071171; AKOS024456739; L000465; SR-01000597510; J-014968; Q7118741; SR-01000597510-1; BRD-A89337244-001-01-1
Click to Show/Hide
|
||||
| Activity |
Ki = 4.37E+14 nM
|
[23] | |||
| Compound Name |
4-[3-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]propyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256923
Click to Show/Hide
|
||||
| Activity |
Ki = 7.41E+14 nM
|
[23] | |||
| Compound Name |
4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)piperidin-4-yl]piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403773
Click to Show/Hide
|
||||
| Activity |
Ki = 1.26E+15 nM
|
[23] | |||
| Compound Name |
4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402207
Click to Show/Hide
|
||||
| Activity |
Ki = 1.66E+15 nM
|
[23] | |||
| Compound Name |
1,1-Diphenyl-4-piperazin-1-ylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258385
Click to Show/Hide
|
||||
| Activity |
Ki = 1.66E+15 nM
|
[23] | |||
| Compound Name |
Diphenidol hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
difenidol hydrochloride; 1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride; Diphenidol HCl; Celmidol; Satanolon; Verterge; Ansmin; Cerrosa; Maniol; Yesdol; 1,1-Diphenyl-4-piperidino-1-butanol hydrochloride; SKF 478 hydrochloride; SK&F 478-A; Diphenidol (hydrochloride); UNII-DG355XWQ4T; Diphenidol hydrochloride [USAN]; DG355XWQ4T; MLS000069816; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride; Difenidolin; Cefadol; Mecalmin; Pineroro; SMR000058238; Tenesdol; Wansar; C21H28ClNO; 1,1-DIPHENYL-4-(PIPERIDIN-1-YL)BUTAN-1-OL HCL; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;hydrochloride; Diphenidol hydrochloride (USAN); SKF 478-A; 1,1-diphenyl-4-piperidylbutan-1-ol, chloride; EINECS 221-850-0; NSC 23012; Difenidol, HCl; Cephadol (TN); Prestwick_886; Vontrol (TN); 1,1-diphenyl-4-(1-piperidyl)butan-1-ol hydrochloride; alpha,alpha-Diphenyl-1-piperidinebutanol hydrochloride; alpha,alpha-Diphenylpiperidine-1-butanol hydrochloride; 1-Piperidinebutanol, alpha,alpha-diphenyl, hydrochloride; ACMC-209htu; Opera_ID_631; CHEMBL1529; Difenidol Hydrochloride,(S); MLS002222273; SCHEMBL195192; Difenidol hydrochloride (JP17); CTK8B1460; DTXSID10186248; HMS1568D06; BCP13983; HY-A0082; KS-000015TY; NSC23012; SK-478-A; AC-335; ANW-27376; MFCD00151479; NSC-23012; s4292; SBB006449; AKOS007930367; CCG-220252; DS-1389; MCULE-4932461593; AK-64514; BR-64514; ST055883; Diphenidol hydrochloride, >=98% (HPLC); AB0011648; D2062; FT-0667646; SW197007-3; A14244; D01318; S-4785; 1,1-Diphenyl-4-piperidino-1-butanolHydrochloride; 254D895; SR-01000721935; 1-Piperidinebutanol,.alpha.-diphenyl, hydrochloride; 1-Piperidinebutanol,.alpha.-diphenyl-, hydrochloride; J-018780; SR-01000721935-2; Q27276383; Z57257314; 1-(4-Hydroxy-4,4-diphenylbutyl)piperidine Hydrochloride; Butanol,1,1-diphenyl-4-(1-piperidyl)-, hydrochloride; .alpha.,.alpha.-Diphenyl-1-piperidinebutanol hydrochloride
Click to Show/Hide
|
||||
| Activity |
Ki = 2.34E+15 nM
|
[23] | |||
| Compound Name |
4-(1-Methylpiperidin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254586
Click to Show/Hide
|
||||
| Activity |
Ki = 5.01E+15 nM
|
[23] | |||
| Compound Name |
1-Methyl-5-(4-(2-(2-(2-(2-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)-1,2,5-thiadiazol-3-yl)-1,2,3,6-tetrahydropyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335542; SCHEMBL4030575; CDD-0273; BDBM50107697; L020961
Click to Show/Hide
|
||||
| Activity |
Ki = 1.00E+16 nM
|
[25] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-Based Design and Discovery of New M 2 Receptor Agonists. J Med Chem. 2017 Nov 22;60(22):9239-9250. | ||||
| REF 2 | Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1546-51. | ||||
| REF 3 | Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4267-74. | ||||
| REF 4 | Synthesis and biological evaluation of Esaprazole analogues showing 1 binding and neuroprotective properties in vitro. Bioorg Med Chem. 2013 Jun 1;21(11):3334-47. | ||||
| REF 5 | Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. J Med Chem. 2008 Jul 10;51(13):3905-12. | ||||
| REF 6 | Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding. Bioorg Med Chem. 2008 Mar 15;16(6):3049-58. | ||||
| REF 7 | Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor. Bioorg Med Chem. 2008 Feb 1;16(3):1376-92. | ||||
| REF 8 | Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. J Med Chem. 2003 Feb 27;46(5):856-67. | ||||
| REF 9 | Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1). J Med Chem. 2014 Nov 13;57(21):9065-77. | ||||
| REF 10 | Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation. Bioorg Med Chem. 2009 Dec 15;17(24):8174-85. | ||||
| REF 11 | Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. Bioorg Med Chem Lett. 2008 Jan 15;18(2):614-8. | ||||
| REF 12 | A rationale for the design and synthesis of m1 selective muscarinic agonists.. Bioorg Med Chem Lett. 1992 Aug;2(8):821-6. | ||||
| REF 13 | Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. J Med Chem. 2006 Mar 23;49(6):1925-31. | ||||
| REF 14 | Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6481-5. | ||||
| REF 15 | Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity. J Med Chem. 1998 Jan 1;41(1):109-16. | ||||
| REF 16 | Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists. J Med Chem. 2013 Feb 28;56(4):1693-703. | ||||
| REF 17 | Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3255-9. | ||||
| REF 18 | 1,4-dioxane, a suitable scaffold for the development of novel M1 muscarinic receptor antagonists. J Med Chem. 2012 Feb 23;55(4):1783-7. | ||||
| REF 19 | Synthesis and In vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2855-7. | ||||
| REF 20 | Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. J Med Chem. 2012 Mar 8;55(5):2125-43. | ||||
| REF 21 | Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor. Bioorg Med Chem Lett. 2012 May 15;22(10):3467-72. | ||||
| REF 22 | Novel benzothiophene H1-antihistamines for the treatment of insomnia. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2316-20. | ||||
| REF 23 | Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. | ||||
| REF 24 | Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists. Bioorg Med Chem. 2007 Jan 15;15(2):886-96. | ||||
| REF 25 | Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras. J Med Chem. 2006 Dec 14;49(25):7518-31. | ||||
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