Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47941 | Target Info | |||
| Target Name | Phosphodiesterase 4 (PDE4) | ||||
| Synonyms |
PDE-4
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|
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 132 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Inamrinone Lactate
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|
Approved | Compound Info | ||
| Synonyms |
Amrinone; inamrinone; 60719-84-8; Wincoram; Inocor; Cordemcura; Cartonic; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Amrinonum [INN-Latin]; Amrinonum; Amrinona; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Amcoral; 5-Amino-(3,4'-bipyridin)-6(1H)-one; WIN 40680; AWD 08-250; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; UNII-JUT23379TN; CCRIS 3794; Amrinone lactate; MLS000069829; EINECS 262-390-0; 5-amino-3,4'-bipyridin-6(1H)-one; BRN 0744819; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; Amrinone Lactate
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|
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| Activity |
IC50 = 101000 nM
|
[1] | |||
| Compound Name |
Enoximone
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Approved | Compound Info | ||
| Synonyms |
ENOXIMONE; Perfan; 77671-31-9; Fenoximone; Enoximonum [Latin]; MDL-17043; Enoximona [Spanish]; MDL 17,043; UNII-C7Z4ITI7L7; MDL-17,043; RMI-17043; 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one; C7Z4ITI7L7; 4-Methyl-5-(p-(methylthio)benzoyl)-4-imidazolin-2-one; CHEMBL249856; 2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-; NCGC00015400-02; Enoximonum; Enoximona; 1,3-Dihydro-4-methyl-5-[4-methylthiobenzoyl]-2H-imidazol-2-one; DSSTox_RID_80702; DSSTox_CID_25147; DSSTox_GSID_45147; Perfane; Enoximona; E 1279; Perfan (TN); Enoximone (USAN/INN); Enoximone [USAN:BAN:INN]; 1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one; FENOXIMONE
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| Activity |
IC50 ~ 150000 nM
|
[2] | |||
| Compound Name |
PMID28870136-Compound-48
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Patented | Compound Info | ||
| Activity |
Ki = 56800 nM
|
[3] | |||
| Compound Name |
ZAPRINAST
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|
Terminated | Compound Info | ||
| Activity |
IC50 = 53000 nM
|
[4] | |||
| Compound Name |
1-Butyl-3,7-dihydro-purine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
1-Butylxanthine; CHEMBL68278; 1-Butyl-3,7-dihydro-purine-2,6-dione; SCHEMBL6233166
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| Activity |
Ki = 71100 nM
|
[5] | |||
| Compound Name |
N6 benzyl-cAMP
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|
Investigative | Compound Info | ||
| Synonyms |
N6-benzyl cyclic AMP
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| Activity |
IC50 = 130000 nM
|
[6] | |||
| Compound Name |
9-BENZYL-9H-ADENINE
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|
Investigative | Compound Info | ||
| Synonyms |
9-Benzyladenine; 4261-14-7; 9-benzyl-9H-purin-6-amine; N9-Benzyladenine; 9-Benzylaminopurine; ADENINE, 9-BENZYL-; 9-Bap; 9-Benzyl-6-aminopurine; N(sup 9)-Benzyladenine; 9-BENZYL-9H-ADENINE; 9-Benzyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 9-(phenylmethyl)-; CCRIS 6908; SQ 21611; 9-benzylpurin-6-amine; NSC 35649; 9-(Phenylmethyl)-9H-purin-6-amine; CHEMBL266094; 9H-Purin-6-amine,9-(phenylmethyl)-; AC1L2FWA; MLS000660735; SCHEMBL104932; 9-Benzyl-9H-purine-6-amine; CTK4I6467; DTXSID70195371; MRHCSNNEUHXNIC-UHFFFAOYSA-N; HMS2676M21
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|
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| Activity |
IC50 = 160000 nM
|
[7] | |||
| Compound Name |
1-METHYLXANTHINE
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|
Investigative | Compound Info | ||
| Synonyms |
1-Methylxanthine; 6136-37-4; 1-Methyl-3,7-dihydro-purine-2,6-dione; 1-Methyl-1H-purine-2,6(3H,7H)-dione; Methylxanthine; Xanthine, 1-methyl-; UNII-7EE8WCA32U; 2,6-Dihydroxy-1-methylpurine; CCRIS 5816; 1-methyl-7H-xanthine; EINECS 228-108-5; 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-; 7EE8WCA32U; CHEMBL1250; 2,6 Dihydroxy-1-methylpurine; CHEBI:68444; 3,7-Dihydro-1-methyl-1H-purine-2,6-dione; MVOYJPOZRLFTCP-UHFFFAOYSA-N; 1-methyl-3,7-dihydropurine-2,6-dione; 1-methyl-3,9-dihydropurine-2,6-dione
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|
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| Activity |
Ki = 163000 nM
|
[5] | |||
| Compound Name |
9-[(4Ar,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-8-amino-3H-purine-6-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142438
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
Triazolothiadiazine, 5H
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400856; BDBM30056; NCGC00165303-01
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|
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-2-hydroxy-6-[6-(methylamino)purin-9-yl]-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142446
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(2-pyridin-2-ylethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539783
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|
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
8-Benzylthio-N-butyl cyclic AMP
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|
Investigative | Compound Info | ||
| Synonyms |
8-Btbca; N(6)-n-Butyl-8-btcamp; SCHEMBL9507382; CHEMBL3142439; 8-Benzylthio-N(6)-n-butyladenosine cyclic-3,5'-monophosphate; SQ-80122; Adenosine, N-butyl-8-((phenylmethyl)thio)-, cyclic 3',5'-(hydrogen phosphate)
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
3,4-Dimethoxy-N-methylsulfonyl-N-(pyridin-3-ylmethyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL92362; SCHEMBL7425188; BDBM50216271
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|
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6,8-bis(methylsulfanyl)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142488
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430828; ZINC4363773; BDBM50216259; CCG-246272; MCULE-5071496293; N-(2-Cyanoethyl)-3,4-dimethoxybenzenesulfonamide #
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|
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)-3-(2-ethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 5J; CHEMBL252787; BDBM30058; ZINC13828737; AKOS016887047; MCULE-6247469728; NCGC00165314-01; Z90279873
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|
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
1,3-Bis(cyclopropylmethyl)-7-methyl-8-[(phenylsulfonyl)amino]xanthine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344720; SCHEMBL7446384; BDBM50040373; N-[1,3-bis(cyclopropylmethyl)-7-methyl-2,6-dioxopurin-8-yl]benzenesulfonamide
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|
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| Activity |
IC50 = 52000 nM
|
[4] | |||
| Compound Name |
9-[(4Ar,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3H-purine-6-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142496
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|
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| Activity |
IC50 = 53000 nM
|
[6] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6-benzylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142479
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|
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| Activity |
IC50 = 53000 nM
|
[6] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-(butylamino)-8-methylsulfanylpurin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142441
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|
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| Activity |
IC50 = 53000 nM
|
[6] | |||
| Compound Name |
N-Butyl-9-[(2-fluorophenyl)methyl]purin-6-amine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542617
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|
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| Activity |
IC50 = 53000 nM
|
[7] | |||
| Compound Name |
2-Pyrrolidinone, 4-(3,4-dimethoxyphenyl)-
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9175; 4-(3,4-dimethoxyphenyl)pyrrolidin-2-one; SCHEMBL7293719; AAL-122; BDBM50017099; AKOS015158031; 4-(3,4-dimethoxyphenyl)-2-pyrrolidone; 4-(3,4-Dimethoxy-phenyl)-pyrrolidin-2-one
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|
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| Activity |
IC50 = 53000 nM
|
[11] | |||
| Compound Name |
1-Methyl-3-propyl-7-[2-(dimethylamino)ethyl]xanthine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286741; BDBM50047243; 7-(2-Dimethylamino-ethyl)-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione
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|
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| Activity |
Ki = 53000 nM
|
[3] | |||
| Compound Name |
8-S-Benzyl cyclic AMP
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|
Investigative | Compound Info | ||
| Synonyms |
8-Benzylthio-camp; 8-Thio-benzyl cyclic amp; CHEMBL3142470; DTXSID70954228; 8-Benzylthioadenosine 3',5'-phosphoric acid; 8-((Phenylmethyl)thio)adenosine, cyclic 3',5'-(hydrogen phosphate)
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|
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| Activity |
IC50 = 53000 nM
|
[6] | |||
| Compound Name |
9-[(2-Fluorophenyl)methyl]-N,8-dimethylpurin-6-amine;methanesulfonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295315
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|
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| Activity |
IC50 = 54000 nM
|
[7] | |||
| Compound Name |
1,3-Bis(cyclopropylmethyl)-7-[[4-(trifluoromethyl)phenyl]sulfonyl]-8-aminoxanthine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358721; SCHEMBL7399332; BDBM50040353; 8-amino-1,3-bis(cyclopropylmethyl)-7-[4-(trifluoromethyl)phenyl]sulfonylpurine-2,6-dione
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|
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| Activity |
IC50 = 54000 nM
|
[4] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-(benzylamino)-8-benzylsulfanylpurin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142447
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|
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| Activity |
IC50 = 56000 nM
|
[6] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[8-benzylsulfanyl-6-(hexylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142453
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|
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| Activity |
IC50 = 56000 nM
|
[6] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6-amino-8-propan-2-ylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142442
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|
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| Activity |
IC50 = 56000 nM
|
[6] | |||
| Compound Name |
1-Benzyl-3-(3-methylsulfinylphenyl)-7H-purine-2,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98654; BDBM50213840; MCULE-8778329280
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| Activity |
IC50 = 56000 nM
|
[12] | |||
| Compound Name |
1,3-Bis(cyclopropylmethyl)-7-(3,4,5-trimethoxybenzyl)-8-[[(4-methoxyphenyl)sulfonyl]amino]xanthine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142922; SCHEMBL7451337; BDBM50040347
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|
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| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
3-(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31838; BDBM50047242; 3-[(3-Propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-1-yl]propanamide
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| Activity |
Ki = 56300 nM
|
[3] | |||
| Compound Name |
(11R,15S)-4-(Cyclopentylmethyl)-8-methyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL305988; BDBM50059024
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|
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| Activity |
IC50 = 57000 nM
|
[13] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6-amino-8-phenylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142465
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|
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| Activity |
IC50 = 57000 nM
|
[6] | |||
| Compound Name |
1-Benzoyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL287311; BDBM50017097
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| Activity |
IC50 = 58000 nM
|
[11] | |||
| Compound Name |
Tocladesine
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Investigative | Compound Info | ||
| Synonyms |
8-Chloro-cAMP; 8-Cl-cAMP; 8-Chloroadenosine 3',5'-monophosphate; UNII-BQ94Z7E5OR; BQ94Z7E5OR; ICN-1256; 8-Chloroadenosine-cyclic-3',5'-monophosphate dihydrate; 8-chloro-cyclic AMP; CCRIS 846; NCS 614491; 8-Chloro-cyclic adenosine monophosphate; Tocladesine [USAN:INN:BAN]; ADENAZOLE; 8-Chloroadenosine 3',5'-cyclic-monophosphate; 8-Chloroadenosine 3',5'-cyclic phosphate; 8-Chloroadenosine-3',5'-O-monophosphate; NSC-614491; Tocladesine (USAN/INN); SCHEMBL125595; CHEMBL2107085; Adenosine, 8-chloro-, cyclic 3',5'-(hydrogen phosphate); ZINC4214493; MFCD00153938; DB13046; NSC 614491; D06173; W-202723; Q27274811
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| Activity |
IC50 = 59000 nM
|
[6] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-amino-8-(4-bromophenyl)sulfanyl-purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
8-p-Bromophenylthio-cAMP; CHEMBL3142492
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|
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| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL509969; BDBM50273985
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|
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| Activity |
IC50 = 60000 nM
|
[14] | |||
| Compound Name |
2-[6-[3-(3,4-Dimethoxyphenyl)-6-oxopyridazin-1-yl]hexyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL192779; BDBM50475192
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|
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| Activity |
IC50 = 60000 nM
|
[15] | |||
| Compound Name |
3-(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL28419; BDBM50047254; 3-[(3-Propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-1-yl]propanoic acid
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| Activity |
Ki = 60000 nM
|
[3] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-(benzylamino)-8-bromopurin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142449
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|
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| Activity |
IC50 = 61000 nM
|
[6] | |||
| Compound Name |
5-(1-Methyl-6-oxo-4,5-dihydropyridazin-3-yl)-1,3-dihydroindol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL37981; SCHEMBL10596136; BDBM50228248
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| Activity |
Ki = 61400 nM
|
[16] | |||
| Compound Name |
3-Ethylxanthine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131181; 3-Ethyl-1H-purine-2,6(3H,7H)-dione; 3-ethyl-7H-purine-2,6-dione; 3-ethylxanthin; NSC515505; SCHEMBL7466316; CTK8I6477; DTXSID80325667; BDBM50001502; AKOS023092889; NSC-515505; 3-Ethyl-3,7-dihydro-purine-2,6-dione
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| Activity |
Ki = 63000 nM
|
[5] | |||
| Compound Name |
4-Spiro[1,3-benzodioxole-2,1'-cyclohexane]-5-ylpyrrolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL52401
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| Activity |
Ki = 63900 nM
|
[17] | |||
| Compound Name |
4-Methyl-5-[4-(4-methylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL27416; SCHEMBL7341617; BDBM50226875; 1,3-Dihydro-4-methyl-5-[4-(4-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one
Click to Show/Hide
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| Activity |
IC50 = 65000 nM
|
[18] | |||
| Compound Name |
N-Benzyl-2-piperidin-1-ylthieno[3,2-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL434822; BDBM50471846
Click to Show/Hide
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| Activity |
IC50 = 65000 nM
|
[19] | |||
| Compound Name |
N-Benzyl-2-(piperidinomethyl)thieno[3,2-d]pyrimidine-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30567; BDBM50223098
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| Activity |
IC50 = 65000 nM
|
[20] | |||
| Compound Name |
T 0156 Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
T-0156 hydrochloride; t-0156; CHEMBL540294; SR-01000076180; SCHEMBL1148363; CTK8I2006; AKOS024456743; NCGC00094459-01; EU-0101212; T 8067; SR-01000076180-1; SR-01000076180-3; Q15634075
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-(butylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142440
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[6] | |||
| Compound Name |
N,N-Diethyladenosine 3',5'-phosphoric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142452
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[6] | |||
| Compound Name |
8-Thiomethyl cyclic AMP
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-503016JFDQ; 503016JFDQ; 8-Thiomethyl-camp; 8-Methylthio-cAMP; 8-(Methylthio)cyclic amp; CHEMBL3306988; SQ 80002; 8-(Methylthio)cyclic 3',5'-adenosine monophosphate; Q27260743; 8-(Methylthio)adenosine cyclic 3',5'-(hydrogen phosphate); adenosine, 8-(methylthio)-cyclic 3',5'-(hydrogen phosphate)
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[6] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447757; BDBM50273987
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[14] | |||
| Compound Name |
1-Methyl-3-propyl-7-(2-methoxyethyl)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28298; BDBM50047240; 7-(2-Methoxy-ethyl)-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
Ki = 72700 nM
|
[3] | |||
| Compound Name |
N-(6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl)pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112996; SCHEMBL6440075; BDBM50147630; N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triaza-benzo[cd]azulen-8-yl)-nicotinamide; N-(4-methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triazabenzo[cd]azulen-8-yl)nicotinamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[21] | |||
| Compound Name |
4-Ethyl-5-[2-methyl-4-(2-methylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26137; BDBM50226864
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[18] | |||
| Compound Name |
N-Ethyl-N-[[4-[2-(tetrazol-2-yl)phenyl]phenyl]methyl]-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150038; BDBM50216458
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[22] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-(butylamino)-8-[(4-chlorophenyl)methylsulfanyl]purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142475
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[6] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-amino-8-[(2-methylphenyl)methylsulfanyl]purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142499
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[6] | |||
| Compound Name |
8-(Ethylthio)adenosine 3',5'-phosphoric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142489
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[6] | |||
| Compound Name |
1-(6-Chloro-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranose 3,5-phosphoric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4737566; CHEMBL3142435
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[6] | |||
| Compound Name |
Triazolothiadiazine, 5E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399422; BDBM30053; ZINC13828696; AKOS008045544; MCULE-8389953648; NCGC00165282-01; 3-(2,4-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[8] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-chloro-8-(diethylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142436
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[6] | |||
| Compound Name |
6-Methylthioinosine-3',5'-cyclic monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-5UB4T9892Z; 5UB4T9892Z; SQ-80025; Cyclic 6-methylthioinosine 3',5'-monophosphate; CHEMBL3142461; 6-Methylthio-9beta-D-ribofuranosylpurine 3',5'-cyclic phosphate; 9-(beta-D-Ribofuranosyl)-6-methylthiopurine-3,5-cyclophosphate; 6-(Methylthio)-9-beta-D-ribofuranosylpurine cyclic 3',5'-monophosphate; 9H-Purine, 6-(methylthio)-9-(3,5-o-phosphinico-beta-D-ribofuranosyl)-; Q27262896
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[6] | |||
| Compound Name |
5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278644; SCHEMBL236619; BDBM50059028; 2,5-dimethyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one; 2,5-Dimethyl-7alpha,8alpha-propano-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purine-4-one; (6aR,9aS)-5,6a,7,8,9,9a-Hexahydro-2,5-dimethyl-cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[13] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6,8-diaminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Amino-cyclic amp; 8-Aminoadenosine 3',5'-monophosphate; SCHEMBL9702440; CHEMBL3142466; CTK4G5577; DTXSID60952930; 8-Aminoadenosine 3',5'-phosphoric acid; 8-AMINOADENOSINE 3:5-CYCLICMONOPHOSPHA TE FREE AC; Adenosine, 8-amino-, cyclic 3',5'-(hydrogen phosphate); Adenosine, 8-amino-,cyclic 3',5'-(hydrogen phosphate) (9CI)
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[6] | |||
| Compound Name |
Methyl 4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-yl(methyl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594160; SCHEMBL4726261; BDBM50304788
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[23] | |||
| Compound Name |
3-Butyl-1-(4-fluorophenyl)-6-phenyl-4,5-dihydropyrazolo[3,4-c]pyridin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307511; BDBM50471679
Click to Show/Hide
|
||||
| Activity |
IC50 = 84700 nM
|
[24] | |||
| Compound Name |
1-(4-Fluorophenyl)-6-(4-methoxyphenyl)-3-propyl-4,5-dihydropyrazolo[3,4-c]pyridin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306335; BDBM50471663
Click to Show/Hide
|
||||
| Activity |
IC50 = 84900 nM
|
[24] | |||
| Compound Name |
4-N,4-N-Diethyl-6,7-dimethoxy-2-N-(2-phenylethyl)quinazoline-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295479; SCHEMBL9199076; BDBM50225323
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[25] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 5C; CHEMBL404633; BDBM30051; ZINC1417183; STK877960; AKOS001996811; CCG-176214; MCULE-5128793377; NCGC00165268-01; ST50422073
Click to Show/Hide
|
||||
| Activity |
IC50 = 88900 nM
|
[8] | |||
| Compound Name |
2-Butyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3144657; BDBM50218421
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[26] | |||
| Compound Name |
N-Benzyl-N-butyl-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL145925; BDBM50216461
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[22] | |||
| Compound Name |
1-(3-Dimethylamino-propyl)-3-propyl-3,7-dihydro-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282160; BDBM50047235; 1-[3-(Dimethylamino)propyl]-3-propylxanthine
Click to Show/Hide
|
||||
| Activity |
Ki = 92000 nM
|
[3] | |||
| Compound Name |
3-(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28684; BDBM50047251; 3-[(1-Methyl-3-propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-7-yl]propanamide
Click to Show/Hide
|
||||
| Activity |
Ki = 92400 nM
|
[3] | |||
| Compound Name |
4-(2-Methoxy-4-pentanoylphenoxy)piperidine-1-carboxylic Acidtert-Butyl Ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL455962; BDBM50273984
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[14] | |||
| Compound Name |
4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289253; SCHEMBL3547095; CTK1E0792; DTXSID80561427; BDBM50017096; 4-(3-Benzyloxy-4-methoxyphenyl)-2-pyrrolidone; 4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one; 4-(3-Benzyloxy-4-methoxy-phenyl)-pyrrolidin-2-one; 4-(4-methoxy-3-phenylmethoxyphenyl)pyrrolidin-2-one; 2-Pyrrolidinone, 4-[4-methoxy-3-(phenylmethoxy)phenyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[11] | |||
| Compound Name |
3-Cyclopentyloxy-N-[(3,4-dimethoxyphenyl)methyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628680; BDBM50129821
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(3,4-dimethoxyphenyl)methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628784; BDBM50129816
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-(3-Chloro-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26348; BDBM50075705
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-[(3,4-dimethoxyphenyl)methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628787; BDBM50129813
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
CCK antagonist synthetic 14
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306760; SCHEMBL8746513; BDBM50019252; PDSP1_000937; PDSP2_000923; N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283360; BDBM50075684
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-[6-Chloro-9-(2-fluorophenyl)-12-oxo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331051; BDBM50217554; L003399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
3-(Cyclopropylmethoxy)-N-[(3,4-dimethoxyphenyl)methyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628682; BDBM50129820
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL456366; BDBM50273331
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
4-[4-(2,3-Dimethylimidazol-3-ium-1-yl)benzoyl]-5-ethyl-1,3-dihydroimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25862; BDBM50226867
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-Cyclopentyl-3,4-dimethoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88119; Oprea1_083849; Oprea1_171971; ZINC5514383; BDBM50216286; STL168287; AKOS000383274; CCG-323233; MCULE-9717757505; N-cyclopentyl-3,4-dimethoxybenzene-1-sulfonamide; Z45537472
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[10] | |||
| Compound Name |
1-(4-Methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1673311; BDBM50336532
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24752; SCHEMBL19197655; BDBM50075691
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24385; BDBM50075687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24715; BDBM50075693
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(3S,4R)-4-[(4S)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295493; BDBM50212895
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
6-Propyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111990; BDBM50471415
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-Benzyl-3-(2-methylsulfinylphenyl)-7H-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328620; BDBM50214510
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
N-(13-Oxo-10-phenyl-1,11-diazatricyclo[7.4.1.05,14]tetradeca-5(14),6,8,10-tetraen-12-yl)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333585; BDBM50217548; L003400
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
4-(3,4-Ethylenedioxyphenyl)-2-pyrrolidone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56083; SCHEMBL11711284; BDBM50212976; AKOS015450664; 4-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Methyl 7-[(2-methylpyridin-4-yl)methyl]-8-oxo-2-(pyrimidin-2-ylmethoxy)-5-(3,4,5-trimethoxyphenyl)-1,7-naphthyridine-6-carboxylate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542410
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-amino-8-(pyridin-3-ylmethylsulfanyl)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142500
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
4-Propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111466; SCHEMBL8133177; BDBM50471417; 4-Propyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(1,3-Benzodioxol-5-yl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000039057; CHEMBL52460; SCHEMBL11708571; HMS2159J18; HMS3315F02; STK537730; AKOS005468232; MCULE-3310949533; SMR000037777; 4-(3,4-Methylendioxyphenyl)-2-pyrrolidon; ST51009297; 4-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
4-Propyl-7,8,9,10-tetrahydropyrimido[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111071; BDBM50471419; 4-Propyl-1,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(3R)-1-(2-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-yl]-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333994; DSSTox_CID_28712; NCGC00183006-01; NCGC00183009-01; DSSTox_RID_82981; DSSTox_GSID_48786; SCHEMBL9120074; DTXSID3048786; FK480; Tox21_113263; BDBM50084033; HY-U00363; (R)-FK-480; CS-7419; CHEMBL333994 (FK-480)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
4-Methyl-5-[4-(2,4,5-trimethylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281304; SCHEMBL7346688; BDBM50226872; 1,3-Dihydro-4-methyl-5-[4-(2,4,5-trimethyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24495; BDBM50075698
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-Propyl-8,9,10,11-tetrahydro-7H-[1,3]diazepino[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108884; BDBM50471420; 4-Propyl-1,4,7,8,9,10-hexahydro-5H-[1,3]diazepino[2,1-i]purin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-methoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25192; BDBM50075686
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-[(11R)-6-Nitro-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344726; BDBM50473091
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N-[(11S)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338657; SCHEMBL9123499; BDBM50217547
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[29] | |||
| Compound Name |
1-(4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl)butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1673313; BDBM50336530
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
N-Ethyl-N-[[2-(tetrazol-2-yl)phenyl]methyl]-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439627; BDBM50216631
Click to Show/Hide
|
||||
| Activity |
IC50 = 107000 nM
|
[22] | |||
| Compound Name |
3-(1-Benzyl-2,6-dioxo-7H-purin-3-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318705; BDBM50214508
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[12] | |||
| Compound Name |
Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-N-tetrahydrofurfuryl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327835; Cerep_004689; Oprea1_720425; SCHEMBL7419340; HMS540K11; BDBM50216264; CCG-43079; MCULE-6113874940; SR-01000633028-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[10] | |||
| Compound Name |
Triazolothiadiazine, 5D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252181; BDBM30052; NCGC00165275-01; 3-(2,3-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[8] | |||
| Compound Name |
1H-Pyridazino(4,5-b)indol-1-one, 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dihydro-, methylhydrazone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
A 80b; A-80b; CHEMBL102012; DTXSID70929052; BDBM50228874; ZINC13825013; 1-Methylhydrazin-4-(3,5-dimethyl-1-pyrazolyl)pyridazino(4,5-b)indole
Click to Show/Hide
|
||||
| Activity |
IC50 = 118000 nM
|
[32] | |||
| Compound Name |
2-(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281972; BDBM50047241; [(1-Methyl-3-propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-7-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
Ki = 119000 nM
|
[3] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[8-benzylsulfanyl-6-(methylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142445
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[6] | |||
| Compound Name |
9-[(2-Fluorophenyl)methyl]-6-piperidin-1-ylpurine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544491
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[7] | |||
| Compound Name |
8-Hydrazinyl-3,4,6,7,16-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,4,7,10,12,14-heptaene-5-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101117; BDBM50228875; 6-Hydrazino-11H-1,2,4-triazolo[4',3':2,3]pyridazino[4,5-b]indole-3-carbohydrazide
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[32] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)-3-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 5B; CHEMBL251982; SCHEMBL4349636; BDBM30050; ZINC5119971; STK795982; AKOS005622610; MCULE-5487768309; ST081706
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[8] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-[6-(ethylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142481
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[6] | |||
| Compound Name |
1-Methyl-3-propyl-7-(2-ethoxyethyl)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283024; BDBM50047232; 7-(2-Ethoxy-ethyl)-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
Ki = 136000 nM
|
[3] | |||
| Compound Name |
(3As,9bR)-7,8-dimethoxy-1,2,3a,4,5,9b-hexahydrobenzo[e]isoindol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL35053; BDBM50017101
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[11] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)-3-(2-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 5I; CHEMBL252586; SCHEMBL4346257; BDBM30057; ZINC5119457; STK795978; AKOS005622572; MCULE-3652721554; NCGC00165308-01; ST50422428
Click to Show/Hide
|
||||
| Activity |
IC50 = 141000 nM
|
[8] | |||
| Compound Name |
8-OH-cAMP
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7,8-Dihydro-8-oxoadenosine-3':5'-cyclic monophosphate; 8-Hydroxyadenosine 3':5'-cyclic monophosphate; CHEMBL3142433; MFCD00079352; ZINC38580996; 7,8-Dihydro-8-oxoadenosine 3':5'-cyclic monophosphate
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[6] | |||
| Compound Name |
3-Methylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2,6-Dihydroxy-3-methylpurine; 3-Methyl-1H-purine-2,6(3H,7H)-dione; 3-methyl-7H-purine-2,6-dione; Xanthine, 3-methyl-; 3-METHYL XANTHINE; 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-; 3,7-Dihydro-3-methyl-1H-purine-2,6-dione; UNII-WS6X982OEC; MFCD00005580; 3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 3-methyl-7H-xanthine; CHEMBL619; WS6X982OEC; 3-methyl-3,7-dihydro-1H-purine-2,6-dione; 3-Methyl-3,9-dihydro-purine-2,6-dione; 3-Methylxanthine, 97%; 3-Methyl-3,9-dihydro-1H-purine-2,6-dione; 3-methyl-1,3-dihydropurine-2,6-dione; CCRIS 5817; 3-methyl-3,7(9)-dihydro-purine-2,6-dione; EINECS 214-058-1; NSC 515466; 3-methyl-xanthine; 3-methyl-9H-xanthine; Spectrum_001898; Theophylline Impurity B; 3-methyl-1H-purine-2,6(3H,9H)-dione; SpecPlus_000737; Spectrum2_000502; Spectrum3_001652; Spectrum4_001571; Spectrum5_001544; 3-Methylxanthine, 98%; N(1)-demethyltheophylline; 2-oxo-3-methylhypoxanthine; ACMC-1BT43; Oprea1_233226; Oprea1_288071; BSPBio_003403; KBioGR_002122; KBioSS_002428; KSC492Q5R; BIDD:GT0266; DivK1c_006833; SCHEMBL237146; SPECTRUM1504182; SPBio_000423; ACMC-2098x5; SCHEMBL8663339; Theophylline Related Compound B; 3-Methyl-3H-purine-2,6-diol; 3-methyl-9H-purine-2,6-dione; CTK3J2858; KBio1_001777; KBio2_002422; KBio2_004990; KBio2_007558; KBio3_002623; KS-00000DPJ; DTXSID90148107; 1-METHYLXANTHINE (1-MX); BCP18161; ZINC4685854; ANW-15831; BBL012772; BDBM50001515; CCG-39565; GEO-01981; NSC515466; s6186; SBB002920; STK776266; WLN: T56 BM DN FNVMVJ F1; AKOS002272340; AKOS004120009; AKOS006221835; ZINC100459831; CS-W020049; DS-1280; LS21223; MCULE-1015315695; NSC-515466; 3-methyl-3,7-dihydropurine-2,6-dione; 1H-Purine-2, 3,7-dihydro-3-methyl-; NCGC00095330-01; NCGC00095330-02; NCGC00178088-01; 3-Methyl-3,7-dihydro-purine-2,6-dione; BR-72940; HY-50723; SC-14084; SY031706; AB0034663; DB-040769; ST4105010; 3,9-dihydro-3-methyl-1H-purine-2,6-dione; AM20080030; FT-0616197; M2073; X8852; C16357; S-2007; 3-Methyl-3,9-dihydro-1H-purine-2,6-dione #; 3-methyl-3,9-dihydro-2H,6H-purine-2,6-dione; 076M228; A801730; J-505016; W-108741; Q27888118; 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl- (9CI); Z1741977122
Click to Show/Hide
|
||||
| Activity |
Ki = 156000 nM
|
[5] | |||
| Compound Name |
Triazolothiadiazine, 5K
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401061; BDBM30059; NCGC00165321-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 159000 nM
|
[8] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6-amino-8-butylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142482
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[6] | |||
| Compound Name |
2-Butyl-5-phenethyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88853; BDBM50218546
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[26] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(8-amino-6-chloropurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142497
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[6] | |||
| Compound Name |
3,6-Bis(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 5G; CHEMBL252585; SCHEMBL4346091; BDBM30055; ZINC5047260; STL364040; AKOS022119194; MCULE-3615571979; NCGC00165296-01; ST50422496
Click to Show/Hide
|
||||
| Activity |
IC50 = 177000 nM
|
[8] | |||
| Compound Name |
8-(4-Chlorophenylthio)-cAMP
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Cpt-camp; 8-Parachlorophenylthio camp; 8-((4-Chlorophenyl)thio)cyclic-3',5'-amp; 8-pCPT-cAMP; CHEMBL230552; Rp-Cpt-camps; chlorophenylthio-cAMP; 8-Ctp-camp; 8-(4-Chlorothiophenyl)cyclic amp; 8-(p-Chlorophenylthio)cyclic-3',5'-amp; 8-(4-chlorophenylthio)-cyclic AMP; 8-p-Chlorophenylthio-cAMP; SCHEMBL7521869; DTXSID6040402; BDBM50215106; MFCD04113723; ZINC12508963; Adenosine, 8-((4-chlorophenyl)thio)-, cyclic 3',5'-(hydrogen phosphate); 8-(4-chlorophenylthio)-3',5'-cyclic AMP; Q27157915; 8-(4-chlorophenylthio)adenosine cyclic 3',5'-phosphate; 8-(4-Chlorophenylthio) adenosine-3',5'-cyclic monophosphate; adenosine, 8-[(4-chlorophenyl)thio]-cyclic 3',5'-(hydrogen phosphate)
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 100 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Thalidomide
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Algosediv; Asmadion; Asmaval; Bonbrain; Bonbrrin; Calmore; Calmorex; Contergan; Corronarobetin; Distaval; Distaxal; Distoval; Ectiluran; Enterosediv; Gastrinide; Glupan; Glutanon; Grippex; Hippuzon; Imidene; Isomin; Kedavon; Kevadon; Neaufatin; Neosedyn; Neosydyn; Nerosedyn; Neufatin; Neurodyn; Neurosedin; Neurosedym; Neurosedyn; Nevrodyn; Nibrol; Noctosediv; Noxodyn; Pangul; Pantosediv; Polygripan; Profarmil; Psycholiquid; Psychotablets; Quetimid; Quietoplex; Sandormin; Sedalis; Sedimide; Sedin; Sedisperil; Sedoval; Shinnibrol; Sleepan; Slipro; Softenil; Softenon; Synovir; Talargan; Talidomida; Talidomide; Talimol; Talismol; Talizer; Telagan; Telargan; Telargean; Tensival; Thaled; Thalidomidum; Thalin; Thalinette; Thalomid; Thalomide; Theophilcholine; Valgis; Valgraine; Yodomin; Celgene Brand of Thalidomide; Talidomide [DCIT]; Thalidomide Celgene; Thalidomide Pharmion; Asidon 3; ENMD 0995; IN1061; Thalidomine USP26; Alpha-Phthalimidoglutarimide; E-217; Imida-lab; Imidan (peyta); N-Phthalimidoglutamic acid imide; N-Phthaloylglutamimide; N-Phthalylglutamic acid imide; Poly-Giron; Predni-Sediv; Pro-Bam M; Pro-ban M; Sedalis sedi-lab; Shin-naito S; THALIDOMIDE (AIDS INITIATIVE); Talidomida [INN-Spanish]; Thaled (TN); Thalidomide (soluble form); Thalidomidum [INN-Latin]; Thalomid (TM); Thalomid (TN); Thalomid, Thalidomide; Alpha-N-Phthalylglutaramide; Thalidomide [USAN:INN:BAN]; Alpha-(N-Phthalimido)glutarimide; N-Phthalyl-glutaminsaeure-imid; N-Phthalyl-glutaminsaeure-imid [German]; Thalidomide (+ and-); Thalidomide (JAN/USP/INN); N-(2,6-Dioxo-3-piperidyl)phthalimide; (+)-Thalidomide; (+-)-Thalidomide; (+/-)-THALIDOMIDE; (inverted question mark)-Thalidomide; 2,6-Dioxo-3-phthalimidopiperidine; 3-Phthalimidoglutarimide
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[33] | |||
| Compound Name |
Xanthine
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
xanthine; 69-89-6; 2,6-Dihydroxypurine; Xanthin; 2,6-dioxopurine; Pseudoxanthine; Isoxanthine; 1H-Purine-2,6(3H,7H)-dione; Xanthic oxide; 1H-Purine-2,6-diol; 9H-Purine-2,6-diol; Purine-2,6-diol; 3,7-Dihydro-1H-purine-2,6-dione; 2,6(1,3)-Purinedion; 1H-Purine-2,6-dione, 3,7-dihydro-; 3,7-dihydropurine-2,6-dione; USAF CB-17; XAN; Purine-2(3H),6(1H)-dione; 2,6-Dioxo-1,2,3,6-tetrahydropurine; 3,9-dihydro-1H-purine-2,6-dione; 9H-Purine-2,6-(1H,3H)-dione; 1H-Purine-2,6-dione, 3,9-dihydro-; Purine-2,6-(1H,3H)-dione; 9H-xanthine
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
3-(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL29052; BDBM50047227; 3-[(1-Methyl-3-propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-7-yl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[3] | |||
| Compound Name |
1-Methyl-3-propyl-7-[3-(dimethylamino)propyl]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28295; BDBM50047234; 7-(3-Dimethylamino-propyl)-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[3] | |||
| Compound Name |
2-Butyl-N-[(4-phenylphenyl)methyl]thieno[3,2-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132267; BDBM50471844
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[19] | |||
| Compound Name |
(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27970; BDBM50047228; [(3-Propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-1-yl]acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[3] | |||
| Compound Name |
2-(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27915; BDBM50047244; [(3-Propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-1-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[3] | |||
| Compound Name |
(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL29209; SCHEMBL10178116; BDBM50047256; [(1-Methyl-3-propyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-7-yl]acetic acid
Click to Show/Hide
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||||
| Activity |
Ki > 200000 nM
|
[3] | |||
| Compound Name |
(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50378; (2R,3S)-EHNA; (2R,3S)-3-(6-aminopurin-9-yl)nonan-2-ol; (2R,3S)-3-(adenin-9-yl)-2-nonanol; (2R,3S)-9-(2-hydroxy-3-nonyl)adenine; erythro-9-(2-hydroxy-3-nonyl)adenine; (R,S)-6-amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; EHNA.HCl; HWC 52; eh-na; Tocris-1261; (-)-erythro-9-(2-hydroxy-3-nonyl)adenine; Lopac0_000504; BSPBio_001061; KBioGR_000401; KBioSS_000401; SCHEMBL1742893; DTXSID6043880; BCBcMAP01_000066; CTK2H9386; KBio2_000401; KBio2_002969; KBio2_005537; KBio3_000761; KBio3_000762; Bio1_000430; Bio1_000919; Bio1_001408; Bio2_000361; Bio2_000841; HMS1792E03; HMS1990E03; HMS3403E03; ZINC1614354; (R-(R*,S*))-6-Amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; BDBM50034908; CCG-36414; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R*,S*)-(+-)-; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R-(R*,S*))-; SDCCGSBI-0050488.P002; 3-(6-Amino-purin-9-yl)-nonan-2-ol; IDI1_002116; SMP2_000310; NCGC00025087-01; NCGC00025087-02; NCGC00025087-03; NCGC00025087-04; NCGC00025087-05; NCGC00025087-06; NCGC00025087-08; (EHNA)3-(6-Amino-purin-9-yl)-nonan-2-ol; 3-(6-Amino-purin-9-yl)-nonan-2-ol(EHNA); (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol; (2R,3S)-3-(6-Amino-9H-purine-9-yl)2-nonanol; (2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol; BRD-K27450477-001-03-9; (2R,3S)-rel-3-(6-Amino-9H-purin-9-yl)nonan-2-ol
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[7] | |||
| Compound Name |
7-Butyl-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131275; 7-butyl-1-methyl-3-propylpurine-2,6-dione; SCHEMBL21381260; XT-77; 1-methyl-3-propyl-7-butylxanthine; ZINC1893708; BDBM50001501; L015783
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[5] | |||
| Compound Name |
7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoindol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32807; BDBM50017104
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[11] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6-amino-8-pentylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142501
Click to Show/Hide
|
||||
| Activity |
IC50 = 290000 nM
|
[6] | |||
| Compound Name |
Sodium;2-[9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-aminopurin-8-yl]sulfanylacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142485
Click to Show/Hide
|
||||
| Activity |
IC50 = 290000 nM
|
[6] | |||
| Compound Name |
3-[2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-hydroxyethyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45542; BDBM50225317
Click to Show/Hide
|
||||
| Activity |
IC50 = 295000 nM
|
[25] | |||
| Compound Name |
(4Ar,6R,7R,7aS)-6-(6-amino-8-propylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142443
Click to Show/Hide
|
||||
| Activity |
IC50 = 310000 nM
|
[6] | |||
| Compound Name |
2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-phenylethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263936; SCHEMBL9198994; BDBM50225318
Click to Show/Hide
|
||||
| Activity |
IC50 = 328000 nM
|
[25] | |||
| Compound Name |
9-[(4Ar,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-chloro-7H-purin-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142437
Click to Show/Hide
|
||||
| Activity |
IC50 = 330000 nM
|
[6] | |||
| Compound Name |
2,2'-Bi[1H-imidazole]-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326133; SCHEMBL10720400; BDBM50228379
Click to Show/Hide
|
||||
| Activity |
IC50 = 339000 nM
|
[2] | |||
| Compound Name |
4-[2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544959; BDBM50225324
Click to Show/Hide
|
||||
| Activity |
IC50 = 339000 nM
|
[25] | |||
| Compound Name |
1H-Pyridazino(4,5-b)indol-1-one, 2,5-dihydro-4-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone, hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555954; 1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)pyridazino(4,5-b)indole; 1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)pyridazino(4,5-b)indole hydrochloride; 1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)pyridazino[4,5-b]indole hydrochloride; CCRIS 6726; 1-HYDRAZINO-4-(3,5-DIMETHYL-1-PYRAZOLYL)PYRIDAZINO[4,5-B]INDOLE; DTXSID20159468; BDBM50228876
Click to Show/Hide
|
||||
| Activity |
IC50 = 348000 nM
|
[32] | |||
| Compound Name |
2-[[2-(Diethylamino)-6,7-dimethoxyquinazolin-4-yl]amino]-1-phenylethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43717; BDBM50225322
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[25] | |||
| Compound Name |
4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL35958; BDBM50017095
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[11] | |||
| Compound Name |
4-[2-[[2-(Diethylamino)-6,7-dimethoxyquinazolin-4-yl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554432; BDBM50225321
Click to Show/Hide
|
||||
| Activity |
IC50 = 428000 nM
|
[25] | |||
| Compound Name |
5-[2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-hydroxyethyl]benzene-1,3-diol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558224; BDBM50225320
Click to Show/Hide
|
||||
| Activity |
IC50 = 432000 nM
|
[25] | |||
| Compound Name |
4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidine-2-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL35893; BDBM50017094
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[11] | |||
| Compound Name |
3-[2-[[2-(Diethylamino)-6,7-dimethoxyquinazolin-4-yl]amino]-1-hydroxyethyl]phenol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541286; BDBM50225325
Click to Show/Hide
|
||||
| Activity |
IC50 = 610000 nM
|
[25] | |||
| Compound Name |
(8Br)-6,7-dimethoxy-3,3a,4,8b-tetrahydro-1H-indeno[2,1-b]pyrrol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36196; BDBM50017116; 5,6-Dimethoxy-3,3a,8,8a-tetrahydro-1H-1-aza-cyclopenta[a]inden-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[11] | |||
| Compound Name |
4-(4-Butoxy-3-methoxy-phenyl)-pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL284399; SCHEMBL11459402; BDBM50017110; 4-(4-butoxy-3-methoxyphenyl)pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
4-(3-Butoxy-phenyl)-pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32226; BDBM50017100
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)pyrrolidine;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36187
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
2-Pyrrolidinone, 4-(3-hydroxy-4-methoxyphenyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL284081; ACMC-20muma; 2-Pyrrolidinone, 4-(3-hydroxy-4-methoxyphenyl)-, (4R)-; SCHEMBL3541828; BDBM50017119; 4-(3-hydroxy-4-methoxyphenyl)-2-pyrrolidone; 4-(3-hydroxy-4-methoxyphenyl)pyrrolidin-2-one; 4-(3-Hydroxy-4-methoxy-phenyl)-pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
4-(4-Butoxy-phenyl)-pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32597; BDBM50017121
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
4-Phenyl-2-pyrrolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Phenyl-2-pyrrolidone; 4-phenylpyrrolidin-2-one; 2-Pyrrolidinone, 4-phenyl-; 4-Phenylpyrrolidone-2; 4-Phenyl-pyrrolidin-2-one; MFCD01687226; 3-phenyl-3,4-dihydro-2H-pyrrol-5-ol; CHEMBL286419; F2147-0209; ChemDiv2_001857; MLS000762405; SCHEMBL531338; CTK8B5664; 4-PHENYL-2-PYROLLIDINONE; DTXSID90923118; HMS1374E09; HMS2800K04; BCP05253; KS-00000E0W; ANW-49506; BDBM50017106; RW3668; STK006864; STL191081; AKOS001683714; AKOS016050334; AKOS016402939; AB09758; CS-W018637; FS-3278; MCULE-4630950069; QC-2398; RAC-4-PHENYL-PYRROLIDIN-2-ONE; NCGC00246500-01; AK-23788; AM803027; BR-23788; SMR000437921; SY031841; AB0035126; DB-083274; FT-0648273; FT-0770801; ST45026099; X9402; S-4116; 198P976; J-515937
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL35392; BDBM50017105; 4-(3,4-dimethoxyphenyl)-2-oxopyrrolidine-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Triazolothiadiazine, 8F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399561; BDBM30087; NCGC00165285-01; 3-(2,5-dimethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 1700000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399759; BDBM30079; ZINC9290616; AKOS000704201; NCGC00165323-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 3200000 nM
|
[8] | |||
| Compound Name |
3-(2-Ethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 8J; CHEMBL252217; BDBM30091; ZINC13828731; AKOS016890545; MCULE-5549238903; NCGC00165311-01; Z103689078
Click to Show/Hide
|
||||
| Activity |
IC50 = 4500000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398825; BDBM30108; NCGC00165280-01; 3-(2,4-dimethoxyphenyl)-6-(2,5-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 5300000 nM
|
[8] | |||
| Compound Name |
6-(2,5-Dimethoxyphenyl)-3-(2-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 10I; CHEMBL253447; BDBM30112; ZINC5123692; STK558031; AKOS005483987; MCULE-3747111199; NCGC00165306-01; ST50422429
Click to Show/Hide
|
||||
| Activity |
IC50 = 6300000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9G
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399350; BDBM30099; NCGC00165293-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 6700000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10G
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253446; BDBM30110; MCULE-6197842772; NCGC00165294-01; ST50422497; 4-[6-(2,5-dimethoxyphenyl)(7H-1,2,4-triazolo[3,4-b]1,3,4-thiadiazin-3-yl)]-1,2 -dimethoxybenzene
Click to Show/Hide
|
||||
| Activity |
IC50 = 6900000 nM
|
[8] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 8G; CHEMBL252215; BDBM30088; ZINC5123743; STK422316; AKOS005454148; MCULE-1973245823; NCGC00165292-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 7500000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252620; BDBM30098; NCGC00165286-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 7500000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254916; BDBM30076; NCGC00165284-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 8000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 8K
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399563; BDBM30092; NCGC00165317-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 8400000 nM
|
[8] | |||
| Compound Name |
3,6-Bis(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000035296; triazolothiadiazine, 8C; MLS000077960; MLS002582756; CHEMBL399761; cid_662872; SCHEMBL4358977; BDBM30084; HMS2400E24; ZINC6793834; STK877956; AKOS005224446; MCULE-2145125597; NCGC00070405-02; EU-0060931; ST50422072; AB00401499-03
Click to Show/Hide
|
||||
| Activity |
IC50 = 8400000 nM
|
[8] | |||
| Compound Name |
6-(3-Methoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 7C; CHEMBL429843; BDBM30073; ZINC6736673; STL284190; AKOS022115570; MCULE-5419585399; NCGC00165264-01; Z55660155
Click to Show/Hide
|
||||
| Activity |
IC50 = 8400000 nM
|
[8] | |||
| Compound Name |
6-(2,5-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 10A; CHEMBL400443; BDBM30104; ZINC5099844; STK554835; AKOS005481112; MCULE-4406527218; NCGC00165253-01; ST081705
Click to Show/Hide
|
||||
| Activity |
IC50 = 8900000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6G
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253202; BDBM30066; NCGC00165290-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 8900000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7G
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428947; BDBM30077; NCGC00165291-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 9000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 8H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399562; SCHEMBL4346756; BDBM30089; NCGC00165299-01; 3-(3,5-dimethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 9500000 nM
|
[8] | |||
| Compound Name |
6-(2,5-Dimethoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 10C; CHEMBL253240; SCHEMBL4352428; BDBM30106; ZINC5071829; STK557115; AKOS005483252; MCULE-9305959682; NCGC00165266-01; ST50422074
Click to Show/Hide
|
||||
| Activity |
IC50 = 10100000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7J
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251815; BDBM30080; NCGC00165310-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 11200000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253445; BDBM30109; NCGC00165287-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 11900000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400444; BDBM30107; NCGC00165273-01; 3-(2,3-dimethoxyphenyl)-6-(2,5-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 = 11900000 nM
|
[8] | |||
| Compound Name |
3-(2-Methoxyphenyl)-6-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 7A; CHEMBL254275; SCHEMBL4341676; BDBM30071; ZINC13828657; AKOS016874219; MCULE-7581284390; NCGC00165250-01; Z55659693
Click to Show/Hide
|
||||
| Activity |
IC50 = 12000000 nM
|
[8] | |||
| Compound Name |
6-(4-Methoxyphenyl)-3-(2-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 8I; CHEMBL252216; SCHEMBL4345024; BDBM30090; ZINC529516; STK795969; AKOS005622529; MCULE-2807529376; NCGC00165305-01; ST50422427
Click to Show/Hide
|
||||
| Activity |
IC50 = 12500000 nM
|
[8] | |||
| Compound Name |
6-(2,5-Dimethoxyphenyl)-3-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000043150; triazolothiadiazine, 10B; MLS000081449; CHEMBL253239; cid_662394; BDBM30105; HMS2406L04; ZINC4325518; STK555759; AKOS005482158; MCULE-7618111435; NCGC00165260-01; ST081707
Click to Show/Hide
|
||||
| Activity |
IC50 = 12600000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254488; BDBM30072; NCGC00165257-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 12600000 nM
|
[8] | |||
| Compound Name |
3-(3-Methoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 8B; CHEMBL252015; SCHEMBL4343311; BDBM30083; ZINC4586140; STK877953; AKOS002045782; CCG-193304; MCULE-2834757152; NCGC00165258-01; ST50422864
Click to Show/Hide
|
||||
| Activity |
IC50 = 12600000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398826; BDBM30111; NCGC00165301-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 12700000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254917; BDBM30078; NCGC00165298-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 13400000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10J
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438337; BDBM30113; NCGC00165312-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 13400000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400881; BDBM30067; NCGC00165297-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 13400000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252419; BDBM30095; NCGC00165265-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 13400000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399884; BDBM30075; NCGC00165277-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 13400000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401062; BDBM30061; NCGC00165256-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 13400000 nM
|
[8] | |||
| Compound Name |
6-[6-(3-Methoxyphenyl)-2,7-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-ylidene]-1-cyclohexa-2,4-dienone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[6-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]phenol; MLS000094779; triazolothiadiazine, 7K; CHEMBL399760; BDBM30081; HMS2378F15; ZINC00424484; NCGC00052169-03; SMR000030332; SR-01000143482; SR-01000143482-1; Q27203084
Click to Show/Hide
|
||||
| Activity |
IC50 = 14100000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252789; BDBM30062; NCGC00165263-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 14100000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403566; BDBM30123; NCGC00165307-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 14100000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252418; BDBM30094; NCGC00165259-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 14100000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11G
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403565; BDBM30121; NCGC00165295-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 14100000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253203; BDBM30068; NCGC00165304-01; NCGC00165304-02
Click to Show/Hide
|
||||
| Activity |
IC50 = 14100000 nM
|
[8] | |||
| Compound Name |
6-(2,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 9A; CHEMBL401402; BDBM30093; ZINC13828659; AKOS016890544; MCULE-3634599964; NCGC00165252-01; Z103662546
Click to Show/Hide
|
||||
| Activity |
IC50 = 15000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252994; BDBM30065; NCGC00165283-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 19600000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253642; BDBM30122; NCGC00165302-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 19600000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253425; BDBM30117; NCGC00165267-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 19700000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399240; BDBM30064; NCGC00165276-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 19700000 nM
|
[8] | |||
| Compound Name |
3-(2-Methoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 8A; CHEMBL251816; SCHEMBL4340764; BDBM30082; ZINC9707920; STL284166; AKOS016362367; MCULE-1738088060; NCGC00165251-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253426; BDBM30119; NCGC00165281-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 7D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254491; BDBM30074; NCGC00165270-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253427; BDBM30120; NCGC00165288-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253029; BDBM30101
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 10K
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253220; BDBM30114; NCGC00165319-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11J
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253643; BDBM30124; NCGC00165313-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11K
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253644; BDBM30125; NCGC00165320-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 8E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252017; SCHEMBL4349946; BDBM30086; ZINC13828688; AKOS008054406; MCULE-4029444925; NCGC00165278-01; 3-(2,4-dimethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399180; BDBM30115; NCGC00165254-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252420; BDBM30097; ZINC13828690; AKOS008054435; MCULE-5593741179; NCGC00165279-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399349; BDBM30096; NCGC00165272-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253221; BDBM30116; NCGC00165261-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9K
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253238; BDBM30103; NCGC00165318-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
3,6-Bis(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 6A; CHEMBL252788; SCHEMBL4343509; BDBM30060; ZINC13828656; AKOS008023999; MCULE-2009042313; NCGC00165249-01; Z55659692
Click to Show/Hide
|
||||
| Activity |
IC50 = 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 11D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403564; BDBM30118; NCGC00165274-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6K
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253408; BDBM30070; NCGC00165316-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 8D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252016; BDBM30085; NCGC00165271-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6D
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252992; BDBM30063; NCGC00165269-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9J
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253030; BDBM30102
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 9H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252621; BDBM30100; NCGC00165300-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Compound Name |
Triazolothiadiazine, 6J
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253204; BDBM30069; NCGC00165309-01
Click to Show/Hide
|
||||
| Activity |
IC50 > 20000000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. J Med Chem. 1997 Sep 26;40(20):3248-53. | ||||
| REF 2 | Synthesis and cardiotonic activity of novel biimidazoles. J Med Chem. 1990 Jan;33(1):317-27. | ||||
| REF 3 | Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. J Med Chem. 1993 May 14;36(10):1380-6. | ||||
| REF 4 | Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem. 1994 Feb 18;37(4):476-85. | ||||
| REF 5 | Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44. | ||||
| REF 6 | Synthesis and enzymatic and inotropic activity of some new 8-substituted and 6,8-disubstituted derivatives of adenosine cyclic 3',5'-monophosphate. J Med Chem. 1980 Mar;23(3):242-51. | ||||
| REF 7 | 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. J Med Chem. 1997 Jun 6;40(12):1768-70. | ||||
| REF 8 | Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303. | ||||
| REF 9 | 1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2341-5. | ||||
| REF 10 | Aryl sulfonamides as selective PDE4 inhibitors. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2635-40. | ||||
| REF 11 | Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. J Med Chem. 1989 Jul;32(7):1450-7. | ||||
| REF 12 | PDE4 inhibitors: new xanthine analogues. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2925-30. | ||||
| REF 13 | Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity. J Med Chem. 1997 Jul 4;40(14):2196-210. | ||||
| REF 14 | Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease. Antimicrob Agents Chemother. 2010 Sep;54(9):3738-45. | ||||
| REF 15 | Design of small-sized libraries by combinatorial assembly of linkers and functional groups to a given scaffold: application to the structure-based optimization of a phosphodiesterase 4 inhibitor. J Med Chem. 2005 Jun 2;48(11):3816-22. | ||||
| REF 16 | Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites. J Med Chem. 1989 Jul;32(7):1476-80. | ||||
| REF 17 | Structure-activity relationships involving the catechol subunit of rolipram. Bioorg Med Chem Lett. 1994 Aug 11;4(15):1855-60. | ||||
| REF 18 | Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents. J Med Chem. 1987 Aug;30(8):1342-7. | ||||
| REF 19 | Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors. J Med Chem. 1998 Oct 8;41(21):4021-35. | ||||
| REF 20 | 3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1403-8. | ||||
| REF 21 | New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. | ||||
| REF 22 | Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds. Bioorg Med Chem Lett. 1998 Mar 3;8(5):505-10. | ||||
| REF 23 | Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533). Bioorg Med Chem Lett. 2010 Jan 1;20(1):383-6. | ||||
| REF 24 | 7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase. J Med Chem. 1998 Jun 18;41(13):2268-77. | ||||
| REF 25 | 2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors. J Med Chem. 1985 Jan;28(1):12-7. | ||||
| REF 26 | Synthesis and biological evaluation of 2,5-dihydropyrazol. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2661-4. | ||||
| REF 27 | Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. Bioorg Med Chem. 2015 Nov 15;23(22):7332-9. | ||||
| REF 28 | 1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. J Med Chem. 1999 Apr 8;42(7):1293-305. | ||||
| REF 29 | Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. Bioorg Med Chem Lett. 2000 Jan 3;10(1):35-8. | ||||
| REF 30 | The selective inhibition of phosphodiesterase IV by benzopyran derivatives of rolipram. Bioorg Med Chem Lett. 1993 Aug;3(8):1743-6. | ||||
| REF 31 | Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indol... J Med Chem. 2000 Dec 14;43(25):4850-67. | ||||
| REF 32 | New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics. J Med Chem. 1991 Oct;34(10):3023-9. | ||||
| REF 33 | Thalidomide analogs and PDE4 inhibition. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. | ||||
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