Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67684 | Target Info | |||
| Target Name | Muscarinic acetylcholine receptor M3 (CHRM3) | ||||
| Synonyms |
M3 receptor; CHRM3
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | CHRM3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 100 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Carbachol
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Carbach; Carbacholin; Carbacholine; Carbacholinum; Carbacholum; Carbacol; Carbacolina; Carbacolo; Carbamiotin; Carbamoylcholine; Carbastat; Carbochol; Carbocholin; Carbocholine; Carbyl; Carcholin; Coletyl; Doryl; Jestryl; Karbachol; Lentin; Lentine; Miostat; Moryl; Rilentol; Vasoperif; CARBACHOL CHLORIDE; Carbachol hydrochloride; Carbacholine chloride; Carbacholini chloridum; Carbacholinium chloratum; Carbacholum chloratum; Carbacolo [DCIT]; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamoylcholine chloride; Carbamylcholine chloride; Choline carbamate chloride; Choline chloride carbamate; Choline chlorine carbamate; Isopto Carbachol; Karbachol [Czech]; Karbamoylcholin chlorid; Karbamoylcholin chlorid [Czech]; Lentine [French]; Mistura C; C 4382; TL 457; C-1770; Carbacholum [INN-Latin]; Carbacol [INN-Spanish]; Carbamic acid, ester with choline chloride; Carbamoylcholine-hydrochloride; Carbastat (TN); Carboptic (TN); Choline chloride, carbamate; Doryl (VAN); Doryl (pharmaceutical); Gamma-Carbamoyl choline chloride; Isopto Carbachol (TN); Miostat (TN); Carbachol [INN:BAN:JAN]; Choline, chloride carbamate(ester); Choline, chloride, carbamate; P. V. Carbachol; Carbachol (JAN/USP/INN); Choline, chloride, carbamate, hydrochloride; Ethanaminium, 2-(aminocarbonyl)oxy-N,N,N-trimethyl-, chloride; Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride (1:1); (2-Carbamoyloxy-ethyl)-trimethyl-ammonium; (2-Carbamoyloxy-ethyl)-trimethyl-ammonium(Carbachol); (2-Carbamoyloxyethyl)trimethylammonium chloride; (2-Hydroxyethyl)trimethyl ammonium chloride carbamate; (2-Hydroxyethyl)trimethylammonium chloride carbamate; (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride; 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride; 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride; 2-carbamoyloxyethyl(trimethyl)azanium chloride
Click to Show/Hide
|
||||
| Activity |
Ki = 51000 nM
|
[1] | |||
| Compound Name |
Risperidone
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Belivon; Risperdal; Risperdone; Risperidal; Risperidona; Risperidonum; Risperin; Rispolept; Rispolin; Sequinan; Risperdal Consta; Risperidona [Spanish]; Risperidonum [Latin]; R 62 766; R 64766; R64766; Consta, Risperdal; KS-1106; R 64,766; R-118; R-64766; R64,766; Risperdal (TN); Risperdal M-Tab; Risperidal M-Tab; Risperidone (RIS); Risperidone, placebo; R 64 766, Risperdal, Risperidone; R-64,766; R-64-766; Risperidone [USAN:BAN:INN]; Risperidone (JAN/USAN/INN); 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one; 3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Aripiprazole
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
129722-12-9; Abilify; Abilitat; Abilify Discmelt; OPC-14597; Discmelt; Opc 14597; OPC 31; OPC-31; 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril; UNII-82VFR53I78; C23H27Cl2N3O2; HSDB 7320; 7-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTOXY)-3,4-DIHYDROQUINOLIN-2(1H)-ONE; CHEMBL1112; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone; CHEBI:31236; Abilify; Aripiprazol; Aripiprazolum; Aripirazole; Arpizol; Asprito; Pripiprazole; Aripiprazole [USAN]; Otsuka brand of aripiprazole; OPC 14597; ALKS-9070; Abilify (TN); BMS-337039; Bristol-Myers Squibb brand of aripiprazole; Discmelt (TN); KS-1030; S06-0010; Aripiprazole (JAN/USAN/INN); 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one; ALKS9070/ALKS9072; Aripiprazole/escitalopram fixed-dose combination
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Arecoline
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
arecoline; Arecholine; Arecaline; 63-75-2; Methylarecaiden; Methylarecaidin; Arecolin; Arekolin; Arecoline base; Arecaidine methyl ester; Arecholin; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester; Methyl N-methyltetrahydronicotinate; C8H13NO2; N-Methyltetrahydronicotinic acid, methyl ester; Methyl 1,2,5,6-tetrahydro-1-methylnicotinate; UNII-4ALN5933BH; NSC 56321; Methyl N-methyl-1,2,5,6-tetrahydronicotinate; CCRIS 7688
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[3] | |||
| Compound Name |
6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489576; BDBM50263936
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Phenylmethoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6587; SCHEMBL10653812
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476990; BDBM50263413; 2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-[1,4'']bipiperidinyl-1''-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[(E)-But-2-enoxy]-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6375
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518747; BDBM50263371
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490597; BDBM50263889; 1-(1''-Benzyl-[1,4'']bipiperidinyl-4-yl)-5-chloro-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490598; BDBM50263890; 4-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521914; BDBM50263893
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477821; SCHEMBL5476466; BDBM50263372; 1-[1''-(2-Chloro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478034; BDBM50263411; 1-[1''-(2-Nitro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2-Methoxyphenyl)-N,N,N-trimethylmethanaminium iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095774; DTXSID70503457; BDBM50246747; NSC167787; NSC-167787
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523657; BDBM50263837; 5-Chloro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(3-Methoxyphenyl)ethyl-trimethylazanium;formate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091934; BDBM50246711
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Fluoro-N-[3-[1-[7-[4-[5-[(4-fluorobenzoyl)amino]-1H-indol-3-yl]piperidin-1-yl]heptyl]piperidin-4-yl]-1H-indol-5-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503468; BDBM50271019
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4,5,6,7-Tetrahydro-[1,2]oxazolo[4,5-c]pyridin-3-one;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6373
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-Propoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6859; SCHEMBL10652707
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491818; BDBM50263937
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Benzyl-3-methoxy-6,7-dihydro-4H-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7482
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(2-Methylpropoxy)-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6377
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(2-Bromoprop-2-enoxy)-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6807
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491208; BDBM50263886; 2-[4-(5-Chloro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-[1,4'']bipiperidinyl-1''-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490797; BDBM50263892; 6-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515489; BDBM50263410; 5-Chloro-1-[1''-(2-chloro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Propan-2-yloxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6702; SCHEMBL10654807
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-Butoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6860; SCHEMBL10651499
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522451; BDBM50263891; 5-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Tbpb
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; CHEMBL522460; GTPL3258; SCHEMBL5473311; BCP13406; TBPB, >=98% (HPLC); BDBM50263887; ZINC40423557; AKOS026750197; CS-3517; NCGC00390669-01; DA-41854; HY-14562; QC-11734; FT-0746315; Y6339; A14205; BRD-K86989957-001-01-7; Q27088942; 1-(1''-(2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1''-2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1a?(2-Methylbenzyl)-1,4a?bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478662; SCHEMBL5486679; BDBM50263370; 1-(1''-(2-(trifluoromethyl)benzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-[1''-(2-Trifluoromethyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL514689; BDBM50263412; 5-Chloro-1-[1''-(2-nitro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227378; BDBM50003015
Click to Show/Hide
|
||||
| Activity |
EC50 = 50118.72 nM
|
[8] | |||
| Compound Name |
N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-2-(1-methyl-3-indolyl)-2-oxoacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294649; N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-2-(1-methylindol-3-yl)-2-oxoacetamide; NCGC00024919-01; Tocris-0988; Biomol-NT_000140; BPBio1_000200; SCHEMBL7379450; ZINC1534160; BDBM50213344; NCGC00024919-02; (R)-RS-56812; Q7277679; BRD-K20714604-001-01-5; BRD-K20714604-003-01-1; (r)-N-(quinuclidin-3-yl)-2-(1-methyl-1 h-indol-3-yl)-2-oxo-acetamide
Click to Show/Hide
|
||||
| Activity |
Ki = 50118.72 nM
|
[9] | |||
| Compound Name |
Schembl21373245
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633665; BDBM50133679
Click to Show/Hide
|
||||
| Activity |
IC50 = 51286.14 nM
|
[10] | |||
| Compound Name |
Schembl21373240
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633663; BDBM50133685
Click to Show/Hide
|
||||
| Activity |
IC50 = 51300 nM
|
[10] | |||
| Compound Name |
Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450729; BDBM50412424; ZINC40835745
Click to Show/Hide
|
||||
| Activity |
Ki = 52480.75 nM
|
[11] | |||
| Compound Name |
2-(4-Methoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL123099
Click to Show/Hide
|
||||
| Activity |
IC50 = 52495.5 nM
|
[12] | |||
| Compound Name |
1-Ethyl-4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid 4-methoxyphenethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1180343; CHEMBL123099; BDBM50073489
Click to Show/Hide
|
||||
| Activity |
IC50 = 52496 nM
|
[13] | |||
| Compound Name |
Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228144; BDBM50003014
Click to Show/Hide
|
||||
| Activity |
EC50 = 56234.13 nM
|
[8] | |||
| Compound Name |
2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391353; BDBM50435313
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[14] | |||
| Compound Name |
Schembl21373237
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633656; BDBM50133682
Click to Show/Hide
|
||||
| Activity |
IC50 = 57543.99 nM
|
[10] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404557
Click to Show/Hide
|
||||
| Activity |
Ki = 61659.5 nM
|
[15] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-1-(2-pyridinylmethylene)-1H-indene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21937; BDBM50219353
Click to Show/Hide
|
||||
| Activity |
Ki = 61659.5 nM
|
[16] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-N-methyl-1-(2-pyridinylmethylene)-1H-indene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL279225; BDBM50219350
Click to Show/Hide
|
||||
| Activity |
Ki = 63095.73 nM
|
[16] | |||
| Compound Name |
Trimethyl-[[(2R,5R)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594376
Click to Show/Hide
|
||||
| Activity |
Ki = 66069.34 nM
|
[17] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-N-methyl-1-(3-pyridinylmethylene)-1H-indene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21328; BDBM50219349
Click to Show/Hide
|
||||
| Activity |
Ki = 72443.6 nM
|
[16] | |||
| Compound Name |
3-[(1-Methylpyrrolidin-3-yl)methoxymethyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091032; BDBM50246702
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[1] | |||
| Compound Name |
[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594802
Click to Show/Hide
|
||||
| Activity |
Ki = 77624.71 nM
|
[17] | |||
| Compound Name |
Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461502; BDBM50412425; ZINC40861610
Click to Show/Hide
|
||||
| Activity |
Ki = 81283.05 nM
|
[11] | |||
| Compound Name |
[(2R,6R)-6-Ethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042401
Click to Show/Hide
|
||||
| Activity |
Ki = 81283.05 nM
|
[18] | |||
| Compound Name |
N-Isopropyl-1-piperazineacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
n-isopropyl-2-(piperazin-1-yl)acetamide; N-isopropyl-2-piperazin-1-ylacetamide; 2-piperazin-1-yl-N-propan-2-ylacetamide; 2-(piperazin-1-yl)-N-(propan-2-yl)acetamide; CHEMBL2391356; 1-Piperazineacetamide, N-(1-methylethyl)-; N-(methylethyl)-2-piperazinylacetamide; EINECS 254-676-9; NSC379438; SCHEMBL255190; CTK4I2048; KS-00003TBM; DTXSID10192925; N-isopropyl-2-piperazinoacetamide; 2-piperazinyl-N-isopropylacetamide; N-isopropyl-1-piperazine acetamide; piperazinoacetic acid isopropylamide; ALBB-006203; 2503AE; BDBM50435342; MFCD00005969; SBB027314; STK501255; ZINC19942920; AKOS000264275; MCULE-4117297184; NSC-379438; VP70271; N-Isopropyl-1-piperazineacetamide, 95%; TS-02582; 1-Piperazineacetamide,N-(1-methylethyl)-; N-Isopropyl-2-(1-piperazinyl)acetamide #; DB-049493; BB 0259628; FT-0639584; ST45024241; EN300-18601; W-6183
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[14] | |||
| Compound Name |
Esaprazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Cyclohexyl-2-piperazin-1-yl-acetamide; Exaprazole; N-cyclohexyl-2-piperazin-1-ylacetamide; N-cyclohexyl-2-(piperazin-1-yl)acetamide; N-Cyclohexyl-1-piperazineacetamide; UNII-38QSU0IB5L; 1-Piperazineacetamide, N-cyclohexyl-; Hexaprazol; 38QSU0IB5L; 1-Piperazineacetamide,N-cyclohexyl-; MFCD00865680; hexaprazole; NCGC00160434-01; DSSTox_CID_26147; DSSTox_RID_81379; DSSTox_GSID_46147; Esaprazole [INN]; Esaprazola; Esaprazolum; Esaprazolum [INN-Latin]; Esaprazola [INN-Spanish]; BRN 0785765; Prazol; N-cyclohexyl-2-piperazin-1-ylacetamide dihydrochloride; 5-23-02-00264 (Beilstein Handbook Reference); MLS004754470; SCHEMBL931007; CHEMBL1983100; DTXSID0046147; CTK5C0914; ALBB-013043; Tox21_111808; 7294AE; BDBM50435343; ZINC19737386; AKOS000209735; Tox21_111808_1; MCULE-8782683340; NE28840; N-cyclohexyl-2-(1-piperazinyl)acetamide; NCGC00160434-02; AS-44244; SMR002529465; n-(cyclohexyl-2-piperazin-1-yl)-acetamide; FT-0678584; EN300-68725; AE-641/00334033; AE-641/30178021; SR-01000883686; SR-01000883686-1; 1-piperazineacetamide, N-cyclohexyl-, dihydrochloride; BRD-K92426617-001-01-4; Q27256807; Z234896745
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[14] | |||
| Compound Name |
4-[Hydroxy(diphenyl)methyl]-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octane Bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478070; SCHEMBL4214478
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[19] | |||
| Compound Name |
Methyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-3-carboxylate;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330885
Click to Show/Hide
|
||||
| Activity |
IC50 = 88401.3 nM
|
[12] | |||
| Compound Name |
(4-Methylpiperazin-1-yl)-[(3E)-3-(pyridin-4-ylmethylidene)inden-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424214; BDBM50219397
Click to Show/Hide
|
||||
| Activity |
Ki = 97723.72 nM
|
[16] | |||
| Compound Name |
N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391367; SCHEMBL975152; BDBM50435331; AKOS032990511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441756
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
6,7,8,9-Tetrahydro-[1,2,5]thiadiazolo[3,4-h]isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL15936; [1,2,5]Thiadiazolo[3,4-h]isoquinoline, 6,7,8,9-tetrahydro; SCHEMBL7810242; BDBM50062157; 6,7,8,9-Tetrahydro-2-thia-1,3,8-triaza-cyclopenta[a]naphthalene
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309717
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441760
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Chembl4286717
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50464891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391366; SCHEMBL974224; BDBM50435332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441750
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441757
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441752
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312346; BDBM50426242
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441751
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500313; BDBM50256181
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309715
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593864
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311547; BDBM50426233
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441754; SCHEMBL21541688; (5S)-5-[(dimethylamino)methyl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441758
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL279105; BDBM50062158; 1,4-Dimethyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391352; BDBM50435314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4294617
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50464883
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391382; SCHEMBL974621; BDBM50435316
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4284346
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50464892
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4277101
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50464890
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
[(2R,5R,6S)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608985
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391374; BDBM50435324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-Naphthalen-1-ylethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312347; BDBM50426241
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220553; BDBM50194316; (5R,2''S)-5[1''-methylpyrrolidin-2''-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359597
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441753
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441759
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391368; SCHEMBL976125; BDBM50435329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391357; SCHEMBL1024404; BDBM50435341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441755
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441761
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
[(2R,5R,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593871
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
1-Ethyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491457; SCHEMBL4215990
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[19] | |||
| Compound Name |
5-(1-Azabicyclo[2.2.1]heptan-3-yl)-1,2,4-oxadiazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314737; 3-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane; 1,2,4-Oxadiazol-3-amine,5-(1-azabicyclo[2.2.1]hept-3-yl)-; 3-(5-(3-Aminoox))abch; ACMC-20c7cn; SCHEMBL9369455; CTK4A8876; DTXSID80921481; BDBM50280565; L001896; L-670207; 1,2,4-Oxadiazol-3-amine, 5-(1-azabicyclo(2.2.1)hept-3-yl)-; 5-(1-Aza-bicyclo[2.2.1]hept-3-yl)-[1,2,4]oxadiazol-3-ylamine; 5-(1-Azabicyclo[2.2.1]heptan-3-yl)-1,2,4-oxadiazol-3(2H)-imine
Click to Show/Hide
|
||||
| Activity |
EC50 = 104000 nM
|
[22] | |||
| Compound Name |
1,1-Diphenyl-2-[1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl]ethanol;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478069
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[19] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168223; BDBM50474495
Click to Show/Hide
|
||||
| Activity |
Ki = 134896.29 nM
|
[23] | |||
| Compound Name |
1-Butyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489020; SCHEMBL4216165
Click to Show/Hide
|
||||
| Activity |
IC50 = 135000 nM
|
[19] | |||
| Compound Name |
2-(1-Azabicyclo[2.2.2]octan-3-yl)-1,1-diphenylethanol;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500306
Click to Show/Hide
|
||||
| Activity |
IC50 = 145000 nM
|
[19] | |||
| Compound Name |
Pyrrolidine, 2-(5-methyl-2-furanyl)-, (2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458416; ZINC4234800; BDBM50412426; AKOS006329069
Click to Show/Hide
|
||||
| Activity |
Ki = 147910.84 nM
|
[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 35 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[Hydroxy(diphenyl)methyl]-1-propyl-1-azoniabicyclo[2.2.2]octane bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522632; SCHEMBL4221105
Click to Show/Hide
|
||||
| Activity |
IC50 = 208000 nM
|
[19] | |||
| Compound Name |
[1-(5-Phenoxypentyl)-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484476
Click to Show/Hide
|
||||
| Activity |
IC50 = 306000 nM
|
[19] | |||
| Compound Name |
4-[Hydroxy(diphenyl)methyl]-1-(2-hydroxyethyl)-1-azoniabicyclo[2.2.2]octane Bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447566; SCHEMBL4224639
Click to Show/Hide
|
||||
| Activity |
IC50 = 486000 nM
|
[19] | |||
| Compound Name |
4-[Hydroxy(diphenyl)methyl]-1-[3-(methyloxy)propyl]-1-azoniabicyclo[2.2.2]octane Bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490856; SCHEMBL4211827
Click to Show/Hide
|
||||
| Activity |
IC50 = 829000 nM
|
[19] | |||
| Compound Name |
[1-(2-Aminoethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]-diphenylmethanol;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489032
Click to Show/Hide
|
||||
| Activity |
IC50 = 850000 nM
|
[19] | |||
| Compound Name |
4-[Hydroxy(diphenyl)methyl]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516121; SCHEMBL4216151
Click to Show/Hide
|
||||
| Activity |
IC50 = 935000 nM
|
[19] | |||
| Compound Name |
1-Azabicyclo[2.2.2]octan-4-yl(diphenyl)methanol;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476436
Click to Show/Hide
|
||||
| Activity |
IC50 = 1068000 nM
|
[19] | |||
| Compound Name |
alpha,alpha-Diphenyl-3-quinuclidinemethanol hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515462; alpha-(3-Quinuclidinyl)benzhydrol hydrobromide; Benzhydrol, alpha-(3-quinuclidinyl)-, hydrobromide; 3-Quinuclidinemethanol, alpha,alpha-diphenyl-, hydrobromide; Benzhydrol, alpha-(1-azabicyclo(2.2.2)oct-3-yl)-, hydrobromide; SCHEMBL11764925; DTXSID10973317; (1-Azabicyclo[2.2.2]octan-3-yl)(diphenyl)methanol--hydrogen bromide (1/1)
Click to Show/Hide
|
||||
| Activity |
IC50 = 1104000 nM
|
[19] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane Bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491456; SCHEMBL4229706
Click to Show/Hide
|
||||
| Activity |
IC50 = 1956000 nM
|
[19] | |||
| Compound Name |
Diphenyl-[1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl]methanol;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516120
Click to Show/Hide
|
||||
| Activity |
IC50 = 2824000 nM
|
[19] | |||
| Compound Name |
2-[2-[4-[Hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-1-yl]ethoxymethyl]benzonitrile;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491252
Click to Show/Hide
|
||||
| Activity |
IC50 = 5403000 nM
|
[19] | |||
| Compound Name |
1-Azabicyclo[2.2.2]octan-2-yl(diphenyl)methanol;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476435
Click to Show/Hide
|
||||
| Activity |
IC50 = 6599000 nM
|
[19] | |||
| Compound Name |
3-[4-[Hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-1-yl]propan-1-ol;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490652
Click to Show/Hide
|
||||
| Activity |
IC50 = 29509000 nM
|
[19] | |||
| Compound Name |
3-Methoxy-4-[12-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]dodecoxy]-1,2,5-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL136027
Click to Show/Hide
|
||||
| Activity |
EC50 = 2.51E+12 nM
|
[24] | |||
| Compound Name |
4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255692
Click to Show/Hide
|
||||
| Activity |
Ki = 2.63E+12 nM
|
[25] | |||
| Compound Name |
4-[4-(4-Hydroxy-4,4-diphenylbutyl)piperazin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404866
Click to Show/Hide
|
||||
| Activity |
Ki = 1.15E+13 nM
|
[25] | |||
| Compound Name |
1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403029
Click to Show/Hide
|
||||
| Activity |
Ki = 1.41E+13 nM
|
[25] | |||
| Compound Name |
(4-Hydroxy-4,4-diphenylbutyl)-[2-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]ethyl]-dimethylazanium;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257586
Click to Show/Hide
|
||||
| Activity |
Ki = 2.29E+13 nM
|
[25] | |||
| Compound Name |
12-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]dodecyl acetate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538793; SCHEMBL4031783
Click to Show/Hide
|
||||
| Activity |
EC50 = 2.51E+13 nM
|
[24] | |||
| Compound Name |
Xanomeline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole; LY 246708; UNII-9ORI6L73CJ; LY-246708; 9ORI6L73CJ; CHEMBL21536; 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE; 141064-23-5 (oxalate); 3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole; 5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine; Xanomeline [USAN:INN]; Pyridine, 3-(4-(hexyloxy)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methyl-; Pyridine,3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-; C14H23N3OS; LY246708; Lumeron; Memcor; Hexyloxy-TZTP; Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-; Xanomeline (USAN); ACMC-20aga8; GTPL57; 3-(4-(Hexyloxy)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine; SCHEMBL121046; CTK4B7643; DTXSID60157286; BCP31492; KS-00000EZ0; ZINC1532358; ANW-72030; BDBM50003359; MFCD00867179; AKOS016007489; DB15357; SB18821; VP14766; NNC-11-0232; AK-57746; DS-15663; FT-0602214; C11767; D06330; L000694; Q8042940; LY-246708; LY246708; LY 246708; 3-(4-hexoxy-1,2,5-thiadiazol-3-yl)-1-methyl-5,6-dihydro-2H-pyridine; 3-(4-hexyloxy-1 ,2,5-thiadiazol-3-yl)-1 ,2,5,6-tetrahydro-1-methyl-pyridine
Click to Show/Hide
|
||||
| Activity |
EC50 = 3.98E+13 nM
|
[24] | |||
| Compound Name |
(4-Hydroxy-4,4-diphenylbutyl)-[3-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]propyl]-dimethylazanium;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403592
Click to Show/Hide
|
||||
| Activity |
Ki = 8.13E+13 nM
|
[25] | |||
| Compound Name |
12-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]dodecan-1-ol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545077; SCHEMBL4029826
Click to Show/Hide
|
||||
| Activity |
EC50 = 1.00E+14 nM
|
[24] | |||
| Compound Name |
4-(1-Methyl-4-phenylpiperazin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257547
Click to Show/Hide
|
||||
| Activity |
Ki = 1.32E+14 nM
|
[25] | |||
| Compound Name |
4-(4-Methylpiperazin-1-yl)-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258161
Click to Show/Hide
|
||||
| Activity |
Ki = 1.35E+14 nM
|
[25] | |||
| Compound Name |
4-[4-(4-Hydroxy-4,4-diphenylbutyl)-4-methylpiperazin-4-ium-1-yl]-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402282
Click to Show/Hide
|
||||
| Activity |
Ki = 1.82E+14 nM
|
[25] | |||
| Compound Name |
4-[4-(1-Methylpiperidin-4-yl)piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257174
Click to Show/Hide
|
||||
| Activity |
Ki = 1.91E+14 nM
|
[25] | |||
| Compound Name |
4-(4,4-Dimethylpiperazin-4-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436850
Click to Show/Hide
|
||||
| Activity |
Ki = 2.45E+14 nM
|
[25] | |||
| Compound Name |
4-[4-(1,1-Dimethylpiperidin-1-ium-4-yl)-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257804
Click to Show/Hide
|
||||
| Activity |
Ki = 2.75E+14 nM
|
[25] | |||
| Compound Name |
4-[3-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]propyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256923
Click to Show/Hide
|
||||
| Activity |
Ki = 5.75E+14 nM
|
[25] | |||
| Compound Name |
Diphenidol hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
difenidol hydrochloride; 1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride; Diphenidol HCl; Celmidol; Satanolon; Verterge; Ansmin; Cerrosa; Maniol; Yesdol; 1,1-Diphenyl-4-piperidino-1-butanol hydrochloride; SKF 478 hydrochloride; SK&F 478-A; Diphenidol (hydrochloride); UNII-DG355XWQ4T; Diphenidol hydrochloride [USAN]; DG355XWQ4T; MLS000069816; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride; Difenidolin; Cefadol; Mecalmin; Pineroro; SMR000058238; Tenesdol; Wansar; C21H28ClNO; 1,1-DIPHENYL-4-(PIPERIDIN-1-YL)BUTAN-1-OL HCL; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;hydrochloride; Diphenidol hydrochloride (USAN); SKF 478-A; 1,1-diphenyl-4-piperidylbutan-1-ol, chloride; EINECS 221-850-0; NSC 23012; Difenidol, HCl; Cephadol (TN); Prestwick_886; Vontrol (TN); 1,1-diphenyl-4-(1-piperidyl)butan-1-ol hydrochloride; alpha,alpha-Diphenyl-1-piperidinebutanol hydrochloride; alpha,alpha-Diphenylpiperidine-1-butanol hydrochloride; 1-Piperidinebutanol, alpha,alpha-diphenyl, hydrochloride; ACMC-209htu; Opera_ID_631; CHEMBL1529; Difenidol Hydrochloride,(S); MLS002222273; SCHEMBL195192; Difenidol hydrochloride (JP17); CTK8B1460; DTXSID10186248; HMS1568D06; BCP13983; HY-A0082; KS-000015TY; NSC23012; SK-478-A; AC-335; ANW-27376; MFCD00151479; NSC-23012; s4292; SBB006449; AKOS007930367; CCG-220252; DS-1389; MCULE-4932461593; AK-64514; BR-64514; ST055883; Diphenidol hydrochloride, >=98% (HPLC); AB0011648; D2062; FT-0667646; SW197007-3; A14244; D01318; S-4785; 1,1-Diphenyl-4-piperidino-1-butanolHydrochloride; 254D895; SR-01000721935; 1-Piperidinebutanol,.alpha.-diphenyl, hydrochloride; 1-Piperidinebutanol,.alpha.-diphenyl-, hydrochloride; J-018780; SR-01000721935-2; Q27276383; Z57257314; 1-(4-Hydroxy-4,4-diphenylbutyl)piperidine Hydrochloride; Butanol,1,1-diphenyl-4-(1-piperidyl)-, hydrochloride; .alpha.,.alpha.-Diphenyl-1-piperidinebutanol hydrochloride
Click to Show/Hide
|
||||
| Activity |
Ki = 8.91E+14 nM
|
[25] | |||
| Compound Name |
Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD 102807; CHEMBL59898; LSM-1888; SCHEMBL5071655; CTK8G2286; DTXSID20407355; HMS3268M09; HMS3412B04; HMS3676B04; BDBM50071171; AKOS024456739; L000465; SR-01000597510; J-014968; Q7118741; SR-01000597510-1; BRD-A89337244-001-01-1
Click to Show/Hide
|
||||
| Activity |
Ki = 1.38E+15 nM
|
[25] | |||
| Compound Name |
4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)piperidin-4-yl]piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403773
Click to Show/Hide
|
||||
| Activity |
Ki = 1.38E+15 nM
|
[25] | |||
| Compound Name |
1,1-Diphenyl-4-piperazin-1-ylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258385
Click to Show/Hide
|
||||
| Activity |
Ki = 1.51E+15 nM
|
[25] | |||
| Compound Name |
4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402207
Click to Show/Hide
|
||||
| Activity |
Ki = 2.69E+15 nM
|
[25] | |||
| Compound Name |
4-(1-Methylpiperidin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254586
Click to Show/Hide
|
||||
| Activity |
Ki = 3.63E+15 nM
|
[25] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-Based Design and Discovery of New M 2 Receptor Agonists. J Med Chem. 2017 Nov 22;60(22):9239-9250. | ||||
| REF 2 | Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect. Eur J Med Chem. 2018 Feb 10;145:74-85. | ||||
| REF 3 | Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity. J Med Chem. 1998 Jan 1;41(1):109-16. | ||||
| REF 4 | Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5439-42. | ||||
| REF 5 | A novel class of conformationally restricted heterocyclic muscarinic agonists. J Med Chem. 1986 Jun;29(6):1004-9. | ||||
| REF 6 | Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. | ||||
| REF 7 | Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5443-7. | ||||
| REF 8 | Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists. Bioorg Med Chem. 2007 Jan 15;15(2):886-96. | ||||
| REF 9 | N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg Med Chem Lett. 1995 Aug 17;5(16):1853-6. | ||||
| REF 10 | Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. J Med Chem. 2015 Nov 25;58(22):8938-51. | ||||
| REF 11 | Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. J Med Chem. 2008 Jul 10;51(13):3905-12. | ||||
| REF 12 | Identification and characterization of m1 selective muscarinic receptor antagonists1. J Med Chem. 1999 Feb 11;42(3):356-63. | ||||
| REF 13 | Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists. J Med Chem. 2013 Feb 28;56(4):1693-703. | ||||
| REF 14 | Synthesis and biological evaluation of Esaprazole analogues showing 1 binding and neuroprotective properties in vitro. Bioorg Med Chem. 2013 Jun 1;21(11):3334-47. | ||||
| REF 15 | Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. Bioorg Med Chem Lett. 2008 Jan 15;18(2):614-8. | ||||
| REF 16 | Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. Bioorg Med Chem Lett. 2001 May 7;11(9):1241-3. | ||||
| REF 17 | Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation. Bioorg Med Chem. 2009 Dec 15;17(24):8174-85. | ||||
| REF 18 | 1,4-dioxane, a suitable scaffold for the development of novel M1 muscarinic receptor antagonists. J Med Chem. 2012 Feb 23;55(4):1783-7. | ||||
| REF 19 | Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem. 2009 Apr 23;52(8):2493-505. | ||||
| REF 20 | Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6481-5. | ||||
| REF 21 | Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3255-9. | ||||
| REF 22 | A rationale for the design and synthesis of m1 selective muscarinic agonists.. Bioorg Med Chem Lett. 1992 Aug;2(8):821-6. | ||||
| REF 23 | Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. J Med Chem. 2003 Feb 27;46(5):856-67. | ||||
| REF 24 | Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders. J Med Chem. 2003 Sep 25;46(20):4273-86. | ||||
| REF 25 | Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.