Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T22118 Target Info
Target Name Dopamine D1 receptor (D1R)
Synonyms D(1A) dopamine receptor
Target Type Successful Target
Gene Name DRD1
Biochemical Class GPCR rhodopsin
UniProt ID
DRD1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Dopamine Ligand Info
Structure Description Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex PDB:7X2F
Method Electron microscopy Resolution 3.00 Å Mutation Yes [1]
PDB Sequence
SVRILTACFL
30
SLLILSTLLG
40
NTLVCAAVIR
50
FRHLRSKVTN
60
FFVISLAVSD
70

LLVAVLVMPW
80
KAVAEIAGFW
90
PFGSFCNIWV
100
AFDIMCSTAS
110
ILNLCVISVD
120

RYWAISSPFR
130
YERKMTPKAA
140
FILISVAWTL
150
SVLISFIPVQ
160
LSWHKAKDNC
186

DSSLSRTYAI
196
SSSVISFYIP
206
VAIMIVTYTR
216
IYRIAQKQIR
226
RIAALERAAV
236

HAKNCFKRET
268
KVLKTLSVIM
278
GVFVCCWLPF
288
FILNCILPFC
298
GFCIDSNTFD
314

VFVWFGWANS
324
SLNPIIYAFN
334
ADFRKAFSTL
344
LG
Residue
Distance (Å)
ASP103
2.521
ILE104
4.225
SER107
3.138
THR108
3.490
LEU190
4.560
TYR194
4.789
SER198
2.166
SER199
4.058
Residue
Distance (Å)
SER202
2.963
TRP285
4.819
PHE288
3.390
PHE289
3.610
ASN292
3.143
VAL317
3.722
TRP321
4.294
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Apomorphine Ligand Info
Structure Description Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein PDB:7JVQ
Method Electron microscopy Resolution 3.00 Å Mutation No [2]
PDB Sequence
SVRILTACFL
30
SLLILSTLLG
40
NTLVCAAVIR
50
FRHLRSKVTN
60
FFVISLAVSD
70

LLVAVLVMPW
80
KAVAEIAGFW
90
PFGSFCNIWV
100
AFDIMCSTAS
110
ILNLCVISVD
120

RYWAISSPFR
130
YERKMTPKAA
140
FILISVAWTL
150
SVLISFIPVQ
160
LSWHKAKPID
184

NCDSSLSRTY
194
AISSSVISFY
204
IPVAIMIVTY
214
TRIYRIAQKQ
224
IRRIAALERA
234

AVHAKNCQFK
265
RETKVLKTLS
275
VIMGVFVCCW
285
LPFFILNCIL
295
PFCFCIDSNT
312

FDVFVWFGWA
322
NSSLNPIIYA
332
FNADFRKAFS
342
TLLGCY
Residue
Distance (Å)
ASP103
3.297
ILE104
4.027
SER107
3.886
THR108
4.026
LEU190
3.577
TYR194
4.955
ALA195
4.922
SER198
2.445
Residue
Distance (Å)
SER199
3.433
SER202
2.974
TRP285
4.100
PHE288
3.562
PHE289
3.618
ASN292
3.074
VAL317
3.673
TRP321
3.349
Ligand Name: PF-06649751 Ligand Info
Structure Description Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-Gs complex PDB:7X2D
Method Electron microscopy Resolution 3.30 Å Mutation Yes [1]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKAKDN
185

CDSSLSRTYA
195
ISSSVISFYI
205
PVAIMIVTYT
215
RIYRIAQKQI
225
RRIAALERAA
235

VHAFKRETKV
270
LKTLSVIMGV
280
FVCCWLPFFI
290
LNCILPFCGF
306
CIDSNTFDVF
316

VWFGWANSSL
326
NPIIYAFNAD
336
FRKAFSTLLG
346
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .86W or .86W2 or .86W3 or :386W;style chemicals stick;color identity;select .F:81 or .F:96 or .F:99 or .F:100 or .F:103 or .F:104 or .F:107 or .F:108 or .F:111 or .F:186 or .F:187 or .F:188 or .F:190 or .F:194 or .F:198 or .F:199 or .F:202 or .F:285 or .F:288 or .F:289 or .F:292 or .F:313 or .F:314 or .F:317 or .F:321; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LYS81
2.838
CYS96
4.885
TRP99
3.987
VAL100
3.692
ASP103
3.029
ILE104
2.262
SER107
3.410
THR108
3.581
ILE111
4.410
CYS186
2.688
ASP187
3.936
SER188
2.904
LEU190
3.136
Residue
Distance (Å)
TYR194
4.579
SER198
3.367
SER199
4.087
SER202
4.083
TRP285
3.877
PHE288
3.224
PHE289
3.689
ASN292
3.521
PHE313
3.410
ASP314
4.234
VAL317
3.744
TRP321
4.427
Ligand Name: A 77636 Ligand Info
Structure Description Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex PDB:7CKX
Method Electron microscopy Resolution 3.54 Å Mutation Yes [3]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKNCDS
188

SLSRTYAISS
198
SVISFYIPVA
208
IMIVTYTRIY
218
RIAQKQIRRI
228
AALERAAVHS
263

FKRETKVLKT
273
LSVIMGVFVC
283
CWLPFFILNC
293
ILPFCCIDSN
311
TFDVFVWFGW
321

ANSSLNPIIY
331
AFNADFRKAF
341
STL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G3O or .G3O2 or .G3O3 or :3G3O;style chemicals stick;color identity;select .R:99 or .R:100 or .R:103 or .R:104 or .R:107 or .R:108 or .R:188 or .R:189 or .R:190 or .R:195 or .R:198 or .R:199 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:313 or .R:317 or .R:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
TRP99
4.957
VAL100
3.672
ASP103
3.119
ILE104
3.631
SER107
2.676
THR108
4.546
SER188
3.259
SER189
4.732
LEU190
3.715
ALA195
4.762
Residue
Distance (Å)
SER198
2.528
SER199
3.406
SER202
3.501
TRP285
3.824
PHE288
3.462
PHE289
3.465
ASN292
3.553
PHE313
3.534
VAL317
3.713
TRP321
3.746
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein PDB:7JVP
Method Electron microscopy Resolution 2.90 Å Mutation No [2]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKAKPN
185

CDSSLSRTYA
195
ISSSVISFYI
205
PVAIMIVTYT
215
RIYRIAQKQI
225
RRIAALERAA
235

VHAKFKRETK
269
VLKTLSVIMG
279
VFVCCWLPFF
289
ILNCILPFCG
299
CIDSNTFDVF
316

VWFGWANSSL
326
NPIIYAFNAD
336
FRKAFSTLLG
346
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .R:55 or .R:61 or .R:64 or .R:65 or .R:68 or .R:72 or .R:76 or .R:94 or .R:95 or .R:98 or .R:102 or .R:105 or .R:141 or .R:144 or .R:148 or .R:152 or .R:156 or .R:160 or .R:196 or .R:200 or .R:204 or .R:208 or .R:268 or .R:271 or .R:272 or .R:275 or .R:276 or .R:279 or .R:280 or .R:282 or .R:283 or .R:284 or .R:286 or .R:287 or .R:290 or .R:293 or .R:294 or .R:297 or .R:308 or .R:309 or .R:312 or .R:316 or .R:326; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG55
3.354
PHE61
3.530
ILE64
3.653
SER65
4.272
VAL68
3.701
LEU72
3.777
LEU76
3.740
SER94
3.943
PHE95
3.652
ILE98
3.630
PHE102
4.285
MET105
4.561
PHE141
3.614
ILE144
3.948
TRP148
3.633
VAL152
3.757
PHE156
3.569
GLN160
3.338
ILE196
4.373
VAL200
3.951
TYR204
3.666
ALA208
4.755
Residue
Distance (Å)
THR268
4.306
LEU271
3.773
LYS272
3.743
SER275
3.258
VAL276
3.732
GLY279
4.817
VAL280
3.734
VAL282
4.410
CYS283
3.684
CYS284
4.743
LEU286
4.413
PRO287
4.086
ILE290
3.801
CYS293
3.894
ILE294
4.198
PHE297
3.621
ILE308
3.835
ASP309
4.649
THR312
4.668
PHE316
4.060
LEU326
4.186
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Razpipadon Ligand Info
Structure Description Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex PDB:7CKY
Method Electron microscopy Resolution 3.20 Å Mutation Yes [3]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKADNC
186

DSSLSRTYAI
196
SSSVISFYIP
206
VAIMIVTYTR
216
IYRIAQKQIR
226
RIAALERAAV
236

HSFKRETKVL
271
KTLSVIMGVF
281
VCCWLPFFIL
291
NCILPFCFCI
308
DSNTFDVFVW
318

FGWANSSLNP
328
IIYAFNADFR
338
KAFSTL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G3U or .G3U2 or .G3U3 or :3G3U;style chemicals stick;color identity;select .R:81 or .R:96 or .R:99 or .R:100 or .R:103 or .R:104 or .R:107 or .R:108 or .R:154 or .R:186 or .R:187 or .R:188 or .R:189 or .R:190 or .R:195 or .R:198 or .R:199 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:313 or .R:314 or .R:317 or .R:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LYS81
2.484
CYS96
4.852
TRP99
3.274
VAL100
3.857
ASP103
3.326
ILE104
3.622
SER107
3.253
THR108
4.577
ILE154
4.820
CYS186
2.817
ASP187
3.395
SER188
3.007
SER189
3.156
Residue
Distance (Å)
LEU190
3.373
ALA195
4.512
SER198
2.699
SER199
2.684
SER202
3.305
TRP285
4.230
PHE288
3.395
PHE289
3.491
ASN292
3.344
PHE313
3.401
ASP314
4.201
VAL317
3.998
TRP321
4.166
Ligand Name: 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, (1S)- Ligand Info
Structure Description Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex PDB:7CRH
Method Electron microscopy Resolution 3.30 Å Mutation Yes [3]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKNCDS
188

SLSRTYAISS
198
SVISFYIPVA
208
IMIVTYTRIY
218
RIAQKQIRRI
228
AALERAAVHS
263

FKRETKVLKT
273
LSVIMGVFVC
283
CWLPFFILNC
293
ILPFCCIDSN
311
TFDVFVWFGW
321

ANSSLNPIIY
331
AFNADFRKAF
341
STL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GBU or .GBU2 or .GBU3 or :3GBU;style chemicals stick;color identity;select .R:100 or .R:103 or .R:104 or .R:107 or .R:108 or .R:188 or .R:190 or .R:195 or .R:198 or .R:199 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:313 or .R:317 or .R:321; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
VAL100
3.728
ASP103
2.831
ILE104
3.559
SER107
3.717
THR108
4.744
SER188
4.698
LEU190
3.477
ALA195
4.493
SER198
3.022
Residue
Distance (Å)
SER199
4.378
SER202
4.025
TRP285
4.953
PHE288
3.120
PHE289
3.304
ASN292
3.772
PHE313
3.074
VAL317
3.039
TRP321
3.811
Ligand Name: Fenoldopam, (R)- Ligand Info
Structure Description Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-Gs complex PDB:7X2C
Method Electron microscopy Resolution 3.20 Å Mutation Yes [1]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKANCD
187

SSLSRTYAIS
197
SSVISFYIPV
207
AIMIVTYTRI
217
YRIAQKQIRR
227
IAALERAAVH
237

AKNCFKRETK
269
VLKTLSVIMG
279
VFVCCWLPFF
289
ILNCILPFCG
299
FCIDSNTFDV
315

FVWFGWANSS
325
LNPIIYAFNA
335
DFRKAFSTL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G3C or .G3C2 or .G3C3 or :3G3C;style chemicals stick;color identity;select .F:81 or .F:99 or .F:100 or .F:103 or .F:104 or .F:107 or .F:108 or .F:111 or .F:164 or .F:187 or .F:188 or .F:189 or .F:190 or .F:194 or .F:195 or .F:198 or .F:199 or .F:202 or .F:285 or .F:288 or .F:289 or .F:292 or .F:310 or .F:313 or .F:314 or .F:317 or .F:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
LYS81
3.168
TRP99
3.350
VAL100
4.410
ASP103
2.424
ILE104
3.522
SER107
3.314
THR108
3.424
ILE111
4.525
HIS164
4.956
ASP187
4.480
SER188
2.788
SER189
3.287
LEU190
3.453
TYR194
4.025
Residue
Distance (Å)
ALA195
4.598
SER198
2.255
SER199
4.024
SER202
3.501
TRP285
4.147
PHE288
3.412
PHE289
3.509
ASN292
3.534
SER310
3.572
PHE313
4.043
ASP314
2.869
VAL317
4.268
TRP321
3.421
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, (1R)- Ligand Info
Structure Description Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein PDB:7JVP
Method Electron microscopy Resolution 2.90 Å Mutation No [2]
PDB Sequence
FSVRILTACF
29
LSLLILSTLL
39
GNTLVCAAVI
49
RFRHLRSKVT
59
NFFVISLAVS
69

DLLVAVLVMP
79
WKAVAEIAGF
89
WPFGSFCNIW
99
VAFDIMCSTA
109
SILNLCVISV
119

DRYWAISSPF
129
RYERKMTPKA
139
AFILISVAWT
149
LSVLISFIPV
159
QLSWHKAKPN
185

CDSSLSRTYA
195
ISSSVISFYI
205
PVAIMIVTYT
215
RIYRIAQKQI
225
RRIAALERAA
235

VHAKFKRETK
269
VLKTLSVIMG
279
VFVCCWLPFF
289
ILNCILPFCG
299
CIDSNTFDVF
316

VWFGWANSSL
326
NPIIYAFNAD
336
FRKAFSTLLG
346
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SK9 or .SK92 or .SK93 or :3SK9;style chemicals stick;color identity;select .R:100 or .R:103 or .R:104 or .R:107 or .R:108 or .R:164 or .R:188 or .R:190 or .R:194 or .R:195 or .R:198 or .R:199 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:313 or .R:317 or .R:321; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
VAL100
3.661
ASP103
3.297
ILE104
3.571
SER107
3.645
THR108
3.500
HIS164
4.962
SER188
3.412
LEU190
3.372
TYR194
4.060
ALA195
4.596
Residue
Distance (Å)
SER198
2.527
SER199
3.914
SER202
3.090
TRP285
4.366
PHE288
3.554
PHE289
3.520
ASN292
3.132
PHE313
3.551
VAL317
3.615
TRP321
3.681
Ligand Name: (1R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Ligand Info
Structure Description Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein PDB:7JV5
Method Electron microscopy Resolution 3.00 Å Mutation No [2]
PDB Sequence
SVRILTACFL
30
SLLILSTLLG
40
NTLVCAAVIR
50
FRHLRSKVTN
60
FFVISLAVSD
70

LLVAVLVMPW
80
KAVAEIAGFW
90
PFGSFCNIWV
100
AFDIMCSTAS
110
ILNLCVISVD
120

RYWAISSPFR
130
YERKMTPKAA
140
FILISVAWTL
150
SVLISFIPVQ
160
LSWHKAKPNC
186

DSSLSRTYAI
196
SSSVISFYIP
206
VAIMIVTYTR
216
IYRIAQKQIR
226
RIAALERAAV
236

HAKNSFKRET
268
KVLKTLSVIM
278
GVFVCCWLPF
288
FILNCILPFC
298
CIDSNTFDVF
316

VWFGWANSSL
326
NPIIYAFNAD
336
FRKAFSTLLG
346
CY
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SK0 or .SK02 or .SK03 or :3SK0;style chemicals stick;color identity;select .R:100 or .R:103 or .R:104 or .R:107 or .R:108 or .R:188 or .R:190 or .R:194 or .R:195 or .R:198 or .R:199 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:313 or .R:317 or .R:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
VAL100
4.072
ASP103
3.008
ILE104
4.154
SER107
3.541
THR108
4.027
SER188
3.459
LEU190
3.367
TYR194
4.437
ALA195
4.431
SER198
3.037
Residue
Distance (Å)
SER199
3.754
SER202
3.579
TRP285
4.743
PHE288
3.589
PHE289
3.724
ASN292
3.228
PHE313
3.821
VAL317
4.804
TRP321
3.797
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Mevidalen Ligand Info
Structure Description Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein PDB:7LJC
Method Electron microscopy Resolution 3.00 Å Mutation No [4]
PDB Sequence
SVRILTACFL
30
SLLILSTLLG
40
NTLVCAAVIR
50
FRHLRSKVTN
60
FFVISLAVSD
70

LLVAVLVMPW
80
KAVAEIAGFW
90
PFGSFCNIWV
100
AFDIMCSTAS
110
ILNLCVISVD
120

RYWAISSPFR
130
YERKMTPKAA
140
FILISVAWTL
150
SVLISFIPVQ
160
LSWHKAKPNC
186

DSSLSRTYAI
196
SSSVISFYIP
206
VAIMIVTYTR
216
IYRIAQKQIR
226
RIAALERAAV
236

HAKNFKRETK
269
VLKTLSVIMG
279
VFVCCWLPFF
289
ILNCILPFCC
307
IDSNTFDVFV
317

WFGWANSSLN
327
PIIYAFNADF
337
RKAFSTLLGC
347
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G4C or .G4C2 or .G4C3 or :3G4C;style chemicals stick;color identity;select .R:123 or .R:127 or .R:130 or .R:131 or .R:134 or .R:135 or .R:138 or .R:139 or .R:142 or .R:143; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
TRP123
3.391
SER127
3.605
ARG130
2.965
TYR131
3.908
LYS134
3.660
Residue
Distance (Å)
MET135
3.810
LYS138
2.667
ALA139
4.007
ILE142
3.801
LEU143
4.141
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione Ligand Info
Structure Description Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist PDB:7JOZ
Method X-ray diffraction Resolution 3.80 Å Mutation No [5]
PDB Sequence
IFEMLRIDEG
1012
LRLKIYKDTE
1022
GYYTIGIGHL
1032
LTKSPSLNAA
1042
KSELDKAIGR
1052

NTNGVITKDE
1062
AEKLFNQDVD
1072
AAVRGILRNA
1082
KLKPVYDSLD
1092
AVRRAALINM
1102

VFQMGETGVA
1112
GFTNSLRMLQ
1122
QKRWDEAAVN
1132
LAKSRWYNQT
1142
PNRAKRVITT
1152

FRTGTWDAYA
1162
SVRILTACFL
30
SLLILSTLLG
40
NTLVCAAVIR
50
FRHLRSKVTN
60

FFVISLAVSD
70
LLVAVLVMPW
80
KAVAEIAGFW
90
PFGSFCNIWV
100
AFDIMCSTAS
110

ILNLCVISVD
120
RYWAISSPFR
130
YERKMTPKAA
140
FILISVAWTL
150
SVLISFIPVQ
160

LSWHNCDSSL
190
SRTYAISSSV
200
ISFYIPVAIM
210
IVTYTRIYRI
220
AQKQIRRIAA
230

LERAAVHAKN
240
CMSFKRETKV
270
LKTLSVIMGV
280
FVCCWLPFFI
290
LNCILPFCGS
300

GETQPFCIDS
310
NTFDVFVWFG
320
WANSSLNPII
330
YAFNADFRKA
340
FSTLLG
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .VFP or .VFP2 or .VFP3 or :3VFP;style chemicals stick;color identity;select .R:99 or .R:100 or .R:103 or .R:104 or .R:107 or .R:108 or .R:186 or .R:187 or .R:188 or .R:189 or .R:190 or .R:198 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:313 or .R:317 or .R:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
TRP99
4.204
VAL100
3.753
ASP103
2.943
ILE104
3.998
SER107
3.070
THR108
4.337
CYS186
2.837
ASP187
4.004
SER188
2.621
SER189
4.472
Residue
Distance (Å)
LEU190
3.504
SER198
3.387
SER202
3.820
TRP285
4.868
PHE288
3.187
PHE289
3.256
ASN292
3.456
PHE313
4.134
VAL317
3.980
TRP321
4.837
References  Top
REF 1 Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun. 2022 Jun 8;13(1):3186.
REF 2 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18.
REF 3 Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 Feb 18;184(4):943-956.e18.
REF 4 Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res. 2021 May;31(5):593-596.
REF 5 Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist. Nat Commun. 2021 Jun 3;12(1):3305.

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