Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T97155 Target Info
Target Name Serine/threonine-protein kinase ATR (FRP1)
Synonyms FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
Target Type Clinical trial Target
Gene Name ATR
Biochemical Class Kinase
UniProt ID
Q13535
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-185-5p miRNA Info
miRNA Mature AC
MIMAT0000455
Sequence uggagagaaaggcaguuccuga
miRNA Species Homo sapiens
Regulation Mechanism miR-185 enhances radiation-induced apoptosis and inhibition of proliferation by repressing ATR pathway. [1]
Evidence Score (E-score) 1 +
1 Western Blot [1]
Representative Target(s) Regulated by This miRNA Androgen receptor (AR) Target Info
ANDR_HUMAN
Arachidonate 12-lipoxygenase (12-LOX) Target Info
LOX12_HUMAN
miRNA Mature ID hsa-miR-383-5p miRNA Info
miRNA Mature AC
MIMAT0000738
Sequence agaucagaaggugauuguggcu
miRNA Species Homo sapiens
Regulation Mechanism miR-383 suppressed ATR expression by targeting 3'untranslated regions (3' UTR) of ATR, and STAT3 down regulates the transcription of miR-383 promoter. [2]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA A proliferation-inducing ligand (APRIL) Target Info
TNF13_HUMAN
G1/S-specific cyclin-D1 (CCND1) Target Info
CCND1_HUMAN
References  Top
REF 1 Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death Dis. 2013 Jun 27;4:e699.
REF 2 STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells. Cell Signal. 2015 Nov;27(11):2285-95.

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