Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15823 Target Info
Target Name Breast cancer type 2 susceptibility protein (BRCA2)
Synonyms Fanconi anemia group D1 protein; FANCD1; FACD
Target Type Literature-reported Target
Gene Name BRCA2
UniProt ID
BRCA2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [1]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [4]
4 Yeast two hybrid [6]
Interacting Protein Name BRCA1-associated RING domain protein 1 (BARD1) Interacting Protein Interacting Protein Info
UniProt ID
BARD1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-purification [8]
3 Reconstituted Complex [8]
Histones [+] 1 Histones +
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [10]
Kinases [+] 3 Kinases +
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [3]
3 Reconstituted Complex [3]
Interacting Protein Name Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) Interacting Protein Interacting Protein Info
UniProt ID
BUB1B_HUMAN 
Synonyms BUB1beta; BUBR1; Bub1A; MAD3L; MVA1; SSK1; hBUBR1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [12]
3 Yeast two hybrid [12]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Protein-peptide [14]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name SMARCE1-related protein (HMG20B) Interacting Protein Interacting Protein Info
UniProt ID
HM20B_HUMAN 
Synonyms BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [16]
4 Affinity Capture-Western [17]
5 Co-localization [15]
6 Co-purification [15]
7 Reconstituted Complex [15]
Other proteins [+] 6 Other proteins +
Interacting Target Name DNA repair protein RAD51 homolog 1 (RAD51) Clinical trial Target Interacting Protein Info
UniProt ID
RAD51_HUMAN 
Synonyms RECA; RAD51A; RAD51 homolog A; HsRAD51; HRAD51
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [18]
3 Affinity Capture-Western [19]
4 Affinity Capture-Western [8]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [17]
7 Affinity Capture-Western [3]
8 Affinity Capture-Western [18]
9 Affinity Capture-Western [20]
10 Affinity Capture-Western [21]
11 Affinity Capture-Western [22]
12 Affinity Capture-Western [23]
13 Affinity Capture-Western [24]
14 Affinity Capture-Western [25]
15 Affinity Capture-Western [26]
16 Affinity Capture-Western [27]
17 Affinity Capture-Western [28]
18 Affinity Capture-Western [29]
19 Affinity Capture-Western [30]
20 Affinity Capture-Western [31]
Interacting Protein Name Partner and localizer of BRCA2 (PALB2) Interacting Protein Interacting Protein Info
UniProt ID
PALB2_HUMAN 
Synonyms FANCN; PNCA3
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [20]
5 Affinity Capture-Western [21]
6 Affinity Capture-Western [32]
7 Affinity Capture-Western [22]
8 Protein-peptide [33]
9 Reconstituted Complex [4]
10 Reconstituted Complex [21]
Interacting Protein Name Fanconi anemia group D2 protein (FANCD2) Interacting Protein Interacting Protein Info
UniProt ID
FACD2_HUMAN 
Synonyms FA.D2; FA4; FACD; FAD; FAD2; FANCD
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [35]
3 Affinity Capture-Western [36]
4 Affinity Capture-Western [37]
5 Affinity Capture-Western [38]
6 Yeast two hybrid [34]
Interacting Protein Name Fanconi anemia group G protein (FANCG) Interacting Protein Interacting Protein Info
UniProt ID
FANCG_HUMAN 
Synonyms FAG; XRCC9
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [35]
3 Affinity Capture-Western [36]
4 Affinity Capture-Western [40]
5 Yeast two hybrid [39]
6 Yeast two hybrid [40]
Interacting Protein Name Split hand/foot deleted protein 1 (SEM1) Interacting Protein Interacting Protein Info
UniProt ID
SEM1_HUMAN 
Synonyms DSS1; ECD; SEM1; SHFD1; SHSF1; Shfdg1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Affinity Capture-Western [42]
3 Co-crystal Structure [43]
4 Co-purification [44]
5 Reconstituted Complex [21]
6 Yeast two hybrid [41]
Interacting Protein Name Microcephalin (MCPH1) Interacting Protein Interacting Protein Info
UniProt ID
MCPH1_HUMAN 
Synonyms BRIT1; MCT
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Co-localization [46]
3 Co-localization [45]
References  Top
REF 1 BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene. 1998 Nov 12;17(19):2531-4.
REF 2 HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing. FEBS J. 2017 Dec;284(23):4035-4050.
REF 3 M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex. J Biol Chem. 2003 Sep 19;278(38):35979-87.
REF 4 PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7155-60.
REF 5 Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals. J Biol Chem. 2001 Oct 5;276(40):37640-8.
REF 6 Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Exp Cell Res. 2003 Oct 1;289(2):211-21.
REF 7 Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res. 2009 Feb 1;69(3):1125-34.
REF 8 Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003 Nov;12(5):1087-99.
REF 9 FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008 Apr 11;30(1):86-97.
REF 10 BRCA1 Forms a Functional Complex with -H2AX as a Late Response to Genotoxic Stress. J Nucleic Acids. 2010 Sep 27;2010. pii: 801594.
REF 11 Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 2004 Jan 29;23(4):865-72.
REF 12 Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1. Cancer Res. 2000 Mar 15;60(6):1531-5.
REF 13 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6.
REF 14 Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies. Biochem Biophys Res Commun. 2003 Nov 28;311(4):803-8.
REF 15 A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Cell. 2001 Jan 26;104(2):247-57.
REF 16 A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7420-5.
REF 17 A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. Oncogene. 2011 Jul 28;30(30):3360-9.
REF 18 Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell. 2006 Jun 23;22(6):719-29.
REF 19 CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature. 2005 Mar 31;434(7033):598-604.
REF 20 APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. EMBO J. 2012 Mar 7;31(5):1160-76.
REF 21 Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. Mol Cell. 2016 Feb 18;61(4):535-546.
REF 22 Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer. Clin Cancer Res. 2017 Nov 1;23(21):6708-6720.
REF 23 Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell. 2003 Oct;12(4):1029-41.
REF 24 The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5287-92.
REF 25 Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51. Genes Chromosomes Cancer. 1998 Mar;21(3):217-22.
REF 26 Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene. 2001 Jan 18;20(3):336-45.
REF 27 Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998 Sep;2(3):317-28.
REF 28 The BRCA2 gene product functionally interacts with p53 and RAD51. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13869-74.
REF 29 Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem. 2005 Apr 15;280(15):14877-83.
REF 30 A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange. Nucleic Acids Res. 2006;34(14):4000-11.
REF 31 Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol. 2010 Oct;17(10):1260-2.
REF 32 Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res. 2011 Apr 5;13(2):R40.
REF 33 Structural basis for recruitment of BRCA2 by PALB2. EMBO Rep. 2009 Sep;10(9):990-6.
REF 34 Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet. 2004 Jun 15;13(12):1241-8.
REF 35 Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance. Mutat Res. 2010 Jul 7;689(1-2):12-20.
REF 36 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene. 2008 Jun 12;27(26):3641-52.
REF 37 Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol. 2004 Jul;24(13):5850-62.
REF 38 Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. Cancer Res. 2009 Nov 15;69(22):8775-83.
REF 39 Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1. Hum Mol Genet. 2003 Oct 1;12(19):2503-10.
REF 40 Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2. DNA Repair (Amst). 2006 May 10;5(5):629-40.
REF 41 Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Mol Cell Biol. 1999 Jul;19(7):4633-42.
REF 42 DSS1 is required for the stability of BRCA2. Oncogene. 2006 Feb 23;25(8):1186-94.
REF 43 BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002 Sep 13;297(5588):1837-48.
REF 44 Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Mol Cell. 2015 Jul 16;59(2):176-87.
REF 45 Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res. 2009 Jul 1;69(13):5531-6.
REF 46 BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 2010 Jan 22;6(1):e1000826.

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