Target General Information
Target ID T56518
Target Name HBV Reverse transcriptase
Species Hepatitis B virus genotype B (HBV-B)
UniProt ID DPOL_HBVB5(347-690)
Sequence EDWGPCTEHGEHRIRTPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGNTRVSWPK
FAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSR
IINNQHRTMQNLHNSCSRNLYVSLMLLYKTYGRKLHLYSHPIILGFRKIPMGVGLSPFLL
AQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYAAVTNFLLSLGIHLNPHKT
KRWGYSLNFMGYVIGSWGTLPQEHIVQKIKMCFRKLPVNRPIDWKVCQRIVGLLGFAAPF
TQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYLNLYPVARQ [Hepatitis B vi
rus genotype B (HBV-B)]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: A181V
Drugs
Drug Name Adefovir Dipivoxil Drug Info [1], [2]
Targeted Disease HBV infection
Mutation Prevalence 843 out of 11751 patients
Mutation Info Missense: A194T
Drugs
Drug Name Tenofovir Disoproxil Fumarate Drug Info [4]
Targeted Disease HBV infection
Mutation Prevalence 2 out of 317 patients
Mutation Info Missense: L180M
Drugs
Drug Name Famciclovir Drug Info [3]
Targeted Disease HBV infection
Mutation Info Missense: M204I
Drugs
Drug Name Telbivudine Drug Info [4]
Targeted Disease HBV infection
Mutation Info Missense: M204V
Drugs
Drug Name Lamivudine Drug Info [1]
Targeted Disease HIV infection; HBV infection
Mutation Info Missense: M204V/I + A181V
Drugs
Drug Name Entecavir + Lamivudine + Adefovir Drug Info [1]
Targeted Disease HBV infection
Mutation Info Missense: M204V/I + M250
Drugs
Drug Name Entecavir Drug Info [1]
Targeted Disease HBV infection
Mutation Info Missense: M204V/I + N236T
Drugs
Drug Name Entecavir + Lamivudine + Adefovir Drug Info [1]
Targeted Disease HBV infection
Mutation Info Missense: M204V/I + T184 + S202
Drugs
Drug Name Entecavir Drug Info [1]
Targeted Disease HBV infection
Mutation Prevalence 78 out of 11751 patients
Drug Name Adefovir Dipivoxil Drug Info [1]
Targeted Disease HBV infection
Mutation Info Missense: N236T
Drugs
Drug Name Adefovir Dipivoxil Drug Info [1], [2]
Targeted Disease HBV infection
Mutation Prevalence 538 out of 11751 patients
Mutation Info Missense: V173L
Drugs
Drug Name Famciclovir Drug Info [3]
Targeted Disease HBV infection
References
REF 1 Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China. Microb Drug Resist. 2017 Jun;23(4):516-522.
REF 2 Screening and identification of a novel adefovir dipivoxil resistance associated mutation, rtN236V, of HBV from a large cohort of HBV-infected patients. Antivir Ther. 2014;19(6):551-8.
REF 3 The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. J Virol. 2003 Nov;77(21):11833-41.
REF 4 [Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology]. Zhonghua Gan Zang Bing Za Zhi. 2016 Jan;24(1):36-9.

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