Resistance mutation info of target

Target General Information

Target ID

T56915

Target Name

HIV Protease

Species

Human immunodeficiency virus type 1 (HIV-1)

UniProt ID

POL_HV1B1(501-599)

Sequence

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF [Human immunodeficie
ncy virus type 1 (HIV-1)]

Drug and Corresponding Resistance Mutations

Mutation Info

Missense: D30N

Drugs

Drug Name	Nelfinavir			Drug Info			[3]
Targeted Disease	HIV infection

Mutation Info

Missense: F53L

Drugs

Drug Name	Nelfinavir			Drug Info			[4], [5], [7]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: G48A

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: G48L

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: G48M

Drugs

Drug Name	Nelfinavir			Drug Info			[7], [15], [16]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: G48Q

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: G48S

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: G48T

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: G48V

Drugs

Drug Name	Nelfinavir			Drug Info			[5]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: G73A

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Mutation Info

Missense: G73C

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Mutation Info

Missense: G73S

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Mutation Info

Missense: G73T

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Mutation Info

Missense: I47A

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Mutation Info

Missense: I47V

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I50L

Drugs

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I50V

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Mutation Info

Missense: I54A

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [18], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I54L

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28], [29]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I54M

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28], [29]

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I54S

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [29]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I54T

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28], [29]

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I54V

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28], [29]

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I84A

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I84C

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: I84V

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: K20T

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Mutation Info

Missense: K65R

Drugs

Drug Name	Nelfinavir	Drug Info	[23]
Targeted Disease	HIV infection
Mutation Prevalence	7 out of 37 samples

Mutation Info

Missense: L10F

Drugs

Drug Name	Nelfinavir			Drug Info			[8], [9], [10]
Targeted Disease	HIV infection

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Mutation Info

Missense: L23I

Drugs

Drug Name	Nelfinavir			Drug Info			[21]
Targeted Disease	HIV infection

Mutation Info

Missense: L24F

Drugs

Drug Name	Nelfinavir			Drug Info			[20], [5]
Targeted Disease	HIV infection

Mutation Info

Missense: L24I

Drugs

Drug Name	Nelfinavir			Drug Info			[6]
Targeted Disease	HIV infection

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Mutation Info

Missense: L33F

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: L76V

Drugs

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Mutation Info

Missense: L89V

Drugs

Drug Name	Nelfinavir			Drug Info			[4], [13], [14]
Targeted Disease	HIV infection

Mutation Info

Missense: L90M

Drugs

Drug Name	Nelfinavir			Drug Info			[1]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28], [29]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: L90M

Drugs

Drug Name	Nelfinavir	Drug Info	[22]
Targeted Disease	HIV infection
Mutation Prevalence	1 out of 31 samples

Mutation Info

Missense: M36I + H69K + L89M

Drugs

Drug Name	Tipranavir			Drug Info			[25]
Targeted Disease	HIV infection

Mutation Info

Missense: M41L

Drugs

Drug Name	Tenofovir + Emtricitabine + Efavirenz			Drug Info			[34]

Mutation Info

Missense: M46*

Drugs

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Mutation Info

Missense: M46I

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: M46L

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: M46V

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Mutation Info

Missense: N83D

Drugs

Drug Name	Nelfinavir			Drug Info			[5], [11], [12]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Mutation Info

Missense: N88D

Drugs

Drug Name	Nelfinavir			Drug Info			[2]
Targeted Disease	HIV infection

Mutation Info

Missense: N88G

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: N88S

Drugs

Drug Name	Nelfinavir			Drug Info			[2]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: N88T

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: Q58E

Drugs

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Mutation Info

Missense: T74P

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Mutation Info

Missense: T74S

Drugs

Drug Name	Ritonavir			Drug Info			[24]
Targeted Disease	HIV infection

Mutation Info

Missense: V32I

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28], [29]

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: V82A

Drugs

Drug Name	Nelfinavir			Drug Info			[4]
Targeted Disease	HIV infection

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: V82C

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [29]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: V82F

Drugs

Drug Name	Nelfinavir			Drug Info			[5]
Targeted Disease	HIV infection

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30]

Drug Name	Darunavir + Ritonavir			Drug Info			[32], [17]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: V82L

Drugs

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [31]

Mutation Info

Missense: V82M

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [29]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [31]

Mutation Info

Missense: V82S

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30], [31]

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

Mutation Info

Missense: V82T

Drugs

Drug Name	Nelfinavir			Drug Info			[17], [19]
Targeted Disease	HIV infection

Drug Name	Saquinavir + Ritonavir			Drug Info			[17], [26], [27]

Drug Name	Fosamprenavir + Ritonavir			Drug Info			[17], [30], [31]

Drug Name	Tipranavir + Ritonavir			Drug Info			[17], [31]

Drug Name	Lopinavir + Ritonavir			Drug Info			[17], [28]

Drug Name	Indinavir + Ritonavir			Drug Info			[17], [27]

Drug Name	Atazanavir + Ritonavir			Drug Info			[17], [33]

References

REF 1

The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients. Ann Intern Med. 1996 Jun 15;124(12):1039-50.

REF 2

Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir. Antimicrob Agents Chemother. 1998 Oct;42(10):2637-44.

REF 3

Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS. 2010 Jan 2;24(1):45-53.

REF 4

Human immunodeficiency virus reverse transcriptase and protease sequence database. Nucleic Acids Res. 2003 Jan 1;31(1):298-303.

REF 5

HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrob Agents Chemother. 2010 Oct;54(10):4253-61.

REF 6

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol. 1996 Dec;70(12):8270-6.

REF 7

Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling. J Virol Methods. 2007 Oct;145(1):47-55.

REF 8

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol. 2008 Jan;82(2):764-74.

REF 9

Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res. 2008 Nov;80(2):213-22.

REF 10

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol. 2008 Nov;82(21):10366-74.

REF 11

Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inh... J Virol. 2006 Nov;80(21):10794-801.

REF 12

Improving the prediction of virological response to tipranavir: the development and validation of a tipranavir-weighted mutation score. Antivir Ther. 2010;15(7):1011-9.

REF 13

Factors associated with the selection of mutations conferring resistance to protease inhibitors (PIs) in PI-experienced patients displaying treatme... Antimicrob Agents Chemother. 2008 Feb;52(2):491-6.

REF 14

Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen. AIDS. 2008 Sep 12;22(14):1809-13.

REF 15

Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance. AIDS. 2003 May 2;17(7):955-61.

REF 16

HIV-1 subtype B protease and reverse transcriptase amino acid covariation. PLoS Comput Biol. 2007 May;3(5):e87.

REF 17

The HIVdb system for HIV-1 genotypic resistance interpretation. Intervirology. 2012;55(2):98-101.

REF 18

Tackling the problem of HIV drug resistance. Postepy Biochem. 2016;62(3):273-279.

REF 19

How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher Biochem J. 2017 Apr 26;474(10):1559-1577.

REF 20

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