Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-(2-(4-fluorophenylamino)ethyl)propanamide | Drug Info |
| Cathepsin K --- MEP | [1-((3S,4S)-2-Oxo-4-phenoxy-azetidin-3-ylcarbamoyl)-cyclohexyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 3-Acetyl-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | [1-(1-Acetyl-4-oxo-pyrrolidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-{(S)-2-Cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-4-(4,6-dimethyl-pyrimidin-2-ylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | pyrrolidine-1-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(indolin-1-yl)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((2S,3S)-2-Butoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(4-methoxy-2,6-dimethylphenylamino)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | 6-Cyclohexylamino-9-((2R,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-furan-2-yl)-9H-purine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | 4-(neopentylamino)-5-(3-(pyridin-3-yloxy)prop-1-ynyl)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-(1,3,4-oxadiazol-2-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-3-tert-butyl-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | 2-((E)-2-Benzenesulfonyl-vinylamino)-N-[3-methyl-1-(3-morpholin-4-yl-ureidocarbonyl)-butyl]-4-phenyl-butyramide | Drug Info |
| Cathepsin K --- MEP | 4-(4-Amino-benzenesulfonylamino)-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methylcyclopentyl)-ethyl]-benzamide | Drug Info |
| Cathepsin K --- MEP | Naphthalene-2-carboxylic acid {(S)-2-cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-{(S)-2-Cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-4-[1,2,4]triazol-1-yl-benzamide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(4-isopropyl-thiazole-2-sulfonylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((S)-1-cyano-2-(4-(trifluoromethyl)phenyl)ethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-4-methyl-2-(2-(5-methyl-1H-imidazol-4-yl)acetamido)pentanamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-3-(1-methylcyclohexyl)-1-oxopropan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | Quinoline-8-carboxylic acid{3-methyl-1-[(S)-(S)-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclohexyl-1-((S)-1-(5-fluoroindolin-1-yl)-4-morpholinobutan-2-ylamino)-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| Cathepsin K --- MEP | 3-Bromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclopentyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxobutan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-pentanoic acid ((S)-cyano-methyl-methyl)-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | (R)-2-{3'-[2-(3-dimethylamino-pyrrolidin-1-yl)-thiazol-4-yl]-biphenyl-yl}-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | (S)-2-(6-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(5-fluoroindolin-1-yl)-4-(methylsulfonyl)butan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | 2-[2-(2-Biphenyl-4-yl-acetylamino)-3-mercapto-propionylamino]-5-guanidino-pentanoic acid [2-(4-hydroxy-phenyl)-1-phenethylcarbamoyl-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-2-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[3-(2-imidazol-1-yl-ethoxy)-4-methoxy-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((S)-1-cyano-2-p-tolylethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 5-(3-(3,4-dihydroisoquinolin-2(1H)-yl)prop-1-ynyl)-4-(neopentylamino)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclopentyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxobutan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | 6-Cyclohexylamino-9-cyclopentyl-9H-purine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | N-[(3R,5S)-1-Cyano-5-methyl-3-pyrrolidinyl]-2,5-bis(methyloxy)benzenesulfonamide | Drug Info |
| Cathepsin K --- MEP | 5-Isopropyl-pyridine-2-carboxylic acid {1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | ((S)-3-Methyl-1-{2-[4-(pyridin-4-ylmethoxy)-phenylamino]-ethylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(3-(methylsulfonyl)phenylamino)propan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(4-methoxyphenylamino)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid (1S,3S,5R)-3,5-dimethyl-cyclohexyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-(7,7-dimethylbicyclo[2.2.1]heptan-1-yl)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopropan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-oxo-1-((3R,4R)-2-oxo-4-phenoxyazetidin-3-ylamino)-3-phenylpropan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-((S)-1-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl)-4-methyl-2-(2,2,2-trifluoroethylamino)pentanamide | Drug Info |
| Cathepsin K --- MEP | (R)-2-{3'-[2-(4-tert-butyl-piperazin-1-yl)-thiazol-4-yl]-biphenyl-3-yl}-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclohexyl-1-((S)-1-(5-fluoroindolin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | 2',3',4'-trifluoro-biphenyl-2-yloxy-acetaldehyde | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-cyclohexyl-1-oxo-1-(2-(4-(trifluoromethoxy)phenylamino)ethylamino)propan-2-yl)furan-3-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-3-cyclohexyl-1-morpholino-1-oxopropan-2-yl (S)-4-phenyl-1-(4-(trifluoromethoxy)phenylamino)butan-2-ylcarbamate | Drug Info |
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