Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK4 | CHEMBL101311 | Drug Info |
| CDK2 --- CDK4 | ((2-chloro-5-methylphenyl)(6-(4-(3-(dimethylamino)-2-hydroxypropoxy)phenylamino)pyrimidin-4-yl)amino)acetonitrile | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | CHEMBL100979 | Drug Info |
| CDK2 --- CSrc | N-(3,5-dimethylphenyl)-4-(5-methylthiazol-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | 4-((2-nitrophenyl)diazenyl)-1H-pyrazole-3,5-diamine | Drug Info |
| CDK2 --- Cyclin E | 1-[(3-Cyclohexyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-ylcarbamoyl)-methyl]-piperidine-4-carboxylic acid amide | Drug Info |
| CDK2 --- Cyclin E | 6-(2-Methylamino-ethyl)-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(3-Cyclopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 5-Amino-3-(4-methoxy-phenyl)-2H-indeno[1,2-c]pyrazol-4-one | Drug Info |
| CDK2 --- Cyclin E | 2-{Benzyl-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- GSK3 | (Z)-2-chloro-4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)benzenesulfonamide | Drug Info |
| CAII --- CAI | N-[4-(dimethylamino)phenyl]sulfamide | Drug Info |
| CDK2 --- JNK1 | 4-(4-(1H-indol-1-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide | Drug Info |
| CAII --- CAI | {[(4-fluorophenyl)sulfonyl]amino}carbonylsulfonamide | Drug Info |
| Chk --- Met | CHEMBL1197456 | Drug Info |
| CAII --- CAI | N-(4-sulfamoylbenzyl)-2-(thiophen-2-yl)acetamide | Drug Info |
| Ckit --- BRaf | 2-((2-carbamothioylpyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| CAII --- CAI | Ethyl1-(3-((2-hydroxynaphthalen-1-yl)diazenyl)phenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1Hpyrazole-4-carboxylate | Drug Info |
| COX2 --- 5LOX | N-{3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-1-methyl-prop-2-ynyl}-N-hydroxy-acetamide | Drug Info |
| CAII --- CAI | 3-[2-(N-Methyl-guanidino)-acetylamino]-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| COX2 --- 5LOX | 3-(4-Trifluoromethylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-benzoic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| COX2 --- HRH1 | Sodium; 11-[2-(4-benzyl-piperidin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylate | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | 6-Methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | (S)-2-[3-(4-Sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| CSrc --- CABL | 4-(1-(2-chloro-2-(4-chlorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[4-(3-sulfamoyl-phenylsulfamoyl)-phenyl]-acetamide | Drug Info |
| CSrc --- CABL | N-butyl-1-(2-chloro-2-(4-fluorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9R,10S,11S,14S,17R)-3,7,12-Trihydroxy-10-(R)-methyl-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-amide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-Oxo-2H-chromene-3-carboxylic acid (4-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- CABL | 2-methoxy-4-(methylthio)-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzamide | Drug Info |
| CAII --- CAI | (S)-3-Phenyl-2-[(S)-2-(4-sulfamoyl-benzoylamino)-propionylamino]-propionic acid | Drug Info |
| CSrc --- FGFR1 | SID109174 | Drug Info |
| CAII --- CAI | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-carbamic acid 4-nitrooxy-butyl ester | Drug Info |
| DHFR --- TYMS | 2-Amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 3-(1H-Imidazol-4-yl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| EGFR --- PDGFR | N-(3,4 Dimethoxyphenyl)6,7dimethoxy quinazolin-4-amine | Drug Info |
| CAII --- CAI | {[(3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- CSrc | 3-{2-[3-(2-Carboxy-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionic acid | Drug Info |
| CAII --- CAI | 4-Hydroxymethyl-N-[2-(N-methyl-guanidino)-acetyl]-benzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | N-(4-Bromophenylsulfonyl)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetamide | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| CAII --- CAI | N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info |
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