Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK4 | 6-Acetyl-2-{5-[bis-(2-methoxy-ethyl)-amino]-pyridin-2-ylamino}-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- CDK4 | 4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | 4-[2-(3-Hydroxy-4-methyl-phenylamino)-pyrimidin-4-yl]-3,5-dimethyl-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- Cyclin E | 2-(3-aminopyrrolidin-1-yl)-N-(biphenyl-4-ylmethyl)-9-isopropyl-9H-purin-6-amine | Drug Info |
| CDK2 --- Cyclin E | (4-Chloro-benzyl)-(2-chloro-9-trifluoromethyl-9H-purin-6-yl)-amine | Drug Info |
| CDK2 --- Cyclin E | N-((1r,4r)-4-(6-(biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)cyclohexyl)-2-cyclopropylacetamide | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-[6-(2-methoxy-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | 2-[[9-Cyclopentyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | 2-[{6-[(Biphenyl-4-ylmethyl)-amino]-9-isopropyl-9H-purin-2-yl}-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N-[3-(4-Methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-2,2-dimethyl-propionamide | Drug Info |
| CDK2 --- Cyclin E | N'-[5-(2-chlorophenyl)-2,10-dihydropyrazolo[3,4-b][1,4]benzodiazepin-7-yl]-N,N-dimethylsulfamide | Drug Info |
| CDK2 --- GSK3 | N-(6-(pyridin-3-yl)furo[2,3-d]pyrimidin-4-yl)cyclopentanecarboxamide | Drug Info |
| CAII --- CAI | 3-amino-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide | Drug Info |
| CDK4 --- Cyclin E | 1-[3-(2,4-Dimethyl-thiazol-5-yl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(3-methoxypropylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | {(2-Hydroxy-phenyl)-[2-((2-hydroxy-phenyl)-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | 3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-1-(4-methoxyphenyl)-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 4-Methyl-5-pentafluorobenzenesulfonylimino-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| COX2 --- 5LOX | (E)-1-(3-(3,7-Dimethylocta-2,6-dien-1-yl)-2,4,6-trihydroxyphenyl)ethanone | Drug Info |
| CAII --- CAI | (4-Fluoro-benzenesulfonylaminocarbonyl)-sulfamic acid | Drug Info |
| COX2 --- 5LOX | 2,6-Di-tert-butyl-4-(2-pyridin-3-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | (1S,3S)-3-Methyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-pentanoic acid methylcarbamoylmethyl with resin | Drug Info |
| CSrc --- CABL | N-(5-(4-methoxybenzylthio)-1,3,4-thiadiazol-2-yl)-4-chlorobenzamide | Drug Info |
| CAII --- CAI | 1-(3-Aminophenyl)-4-benzoyl-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazole-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| CSrc --- CABL | N-benzyl-1-(2-chloro-2-phenylethyl)-6-(propylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-ethylhexanamide | Drug Info |
| CSrc --- CABL | N4-benzyl-1-(2-chloro-2-phenylethyl)-N6,N6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid | Drug Info |
| CSrc --- CABL | N-(5-(4-bromobenzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | N-(2-bromo-4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide | Drug Info |
| CSrc --- CABL | (E)-3-(2-(Purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| CAII --- CAI | 4-isothiocyanatobenzenesulfonamide | Drug Info |
| CSrc --- Ckit | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-phenylpyridin-2(1H)-one | Drug Info |
| CAII --- CAI | 2-Amino-N-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-acetamide | Drug Info |
| DHFR --- TYMS | 4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyric acid anion | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| DHFR --- TYMS | 2-[4-(2-Amino-6-methyl-4-oxo-4,4a,7,7a-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylsulfanyl)-benzoylamino]-pentanedioic acid | Drug Info |
| CAII --- CAI | SID527148 | Drug Info |
| EGFR --- HER2 | N-(2-chlorophenyl)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | Drug Info |
| CAII --- CAI | [(2-Hydroxy-phenyl)-(2-{(2-hydroxy-phenyl)-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| EGFR3 --- CABL | (5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-m-tolyl-amine | Drug Info |
| CAII --- CAI | 4-Sulfamoyl-N-(4-sulfamoyl-phenyl)-benzamide | Drug Info |
| EGFR3 --- CSrc | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile | Drug Info |
| CAII --- CAI | 2-isopropyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| EGFR3 --- HER2 | 2-(2-(5-Chloro-2-hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | (S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-3-phenyl-propionic acid | Drug Info |
| EGFR3 --- HER2 | 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-isopropyl oxime | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-((S)-indan-1-yloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
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