Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- AuroraA | 8-[(2-Fluorophenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N,1,4,4-Tetramethyl-8-{[3-(morpholin-4-ylmethyl)phenyl]-amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CD135 | (16E)-4,14-Dimethyl-20-oxa-5,7,14,26-tetraazatetracyclo-[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8-(27),9,11,16,21,23-decaene | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(cyclopentylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | 4-(2-(4-chloro-5-methoxy-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(6-ethyl-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-dimethyl-benzamide | Drug Info |
| CDK2 --- CDK1 | ((S)-3-(cyclopropylamino)pyrrolidin-1-yl)(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)phenyl)methanone | Drug Info |
| CDK2 --- CDK1 | 4-(4-Amino-6-cyclohexylmethoxy-5-nitroso-pyrimidin-2-ylamino)-benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}-6-bromoisoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | [4-(2-Allylamino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | (4-Chloro-3-trifluoromethyl-phenyl)-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- CDK4 | [4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-[5-((R)-3-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | 1-(4-Methoxy-phenyl)-3-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-urea | Drug Info |
| CDK2 --- Cyclin E | 2-{(2-Hydroxy-ethyl)-[6-(4-methoxy-benzylamino)-9-naphthalen-2-ylmethyl-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | N6-(2,2'-bithiophen-5-ylmethyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 7-chloro-5-(2-fluorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | 6-(4-Dimethylamino-benzyl)-3-ethyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-3-isopropyl-7-nitro-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | 2-Amino-1-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-ethanol | Drug Info |
| CDK2 --- GSK3 | [4-(6-Methyl-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(4-trifluoromethyl-phenyl)-amine | Drug Info |
| CAII --- CAI | sodium 4-fluorobenzoate | Drug Info |
| CDK2 --- JNK1 | 4-(5-chloro-4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide | Drug Info |
| CAII --- CAI | (S)-2-[3-(4-Chloro-3-sulfamoyl-benzoylamino)-propionylamino]-3-(3H-imidazol-4-yl)-propionic acid | Drug Info |
| Chk --- Met | CHEMBL1197320 | Drug Info |
| CAII --- CAI | 2-ethyl-N-(4-sulfamoylphenyl)hexanamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-hydroxyethyl)picolinamide | Drug Info |
| CAII --- CAI | 3-Hydroxy-2-[3-(4-sulfamoyl-phenyl)-thioureido]-butyric acid | Drug Info |
| COX2 --- 5LOX | 4-[2-(4-Fluoro-phenyl)-hex-1-enyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | 2-ethyl-N-hydroxyhexanamide | Drug Info |
| COX2 --- 5LOX | 2,6-Diethyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | Phosphoric acid ethyl ester methyl ester 4-nitro-phenyl ester | Drug Info |
| COX2 --- HRH1 | 11-[2-(4-Benzyl-piperazin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(1H-imidazol-1-yl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 2-{3-(1H-Imidazol-4-yl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionylamino}-3-phenyl-propionic acid | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-{[(morpholin-4-ylcarbonothioyl)thio]amino}benzenesulfonamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N,N-diethyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | {(2-{2-[2-(Bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethyl)-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile | Drug Info |
| CAII --- CAI | 4-[2-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-ethyl]-benzenesulfonamide | Drug Info |
| CSrc --- CD221 | N'-(4-tert-Butylbenzoyl)-2-(1H-indol-3-yl)-2-oxoacetohydrazide | Drug Info |
| CAII --- CAI | N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info |
| CSrc --- TEK | 1-Methyl-1H-indole-2-carboxylic acid (4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxy-phenyl)-amide | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester | Drug Info |
| DHFR --- TYMS | 2-Amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | Drug Info |
| CAII --- CAI | Diethyl-2-((3-(4-benzoyl-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)diazenyl)malonate | Drug Info |
| EGFR --- HER2 | 2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile | Drug Info |
| CAII --- CAI | 4-Carbamoyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-butyric acid | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.