Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | CHEMBL450061 | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((3R,4S)-2-Oxo-4-phenylsulfanyl-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-picolinoylazepan-4-ylamino)-3-(1-methylcyclohexyl)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-((S)-3-1H-indol-3-yl-2-isopropoxycarbonylamino-propionylamino)-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | H-Tyr-D-Ala-Gly-Phe-NH-NH-(NMe)Phe-Asp-Lys(Cpac)-Trp-Ac | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5S,7R)-5-(2-ethyl-phenyl)-2-oxo-7-phenyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | N-{1-[1-[({2-[2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-methyl)-carbamoyl]-2-(1H-indol-3-yl)-ethylcarbamoyl]-pentyl}-3-(3-phenyl-propionylamino)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 1-[(S)-2-(4-Benzoyl-piperidin-1-yl)-1-benzylsulfanylmethyl-2-oxo-ethyl]-3-m-tolyl-urea | Drug Info |
| CCKBR --- CCKAR | 1-[(S)-2-(4-Benzoyl-piperidin-1-yl)-2-oxo-1-phenylmethanesulfinylmethyl-ethyl]-3-m-tolyl-urea | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5S,7R)-2-oxo-5-phenyl-7-m-tolyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | (R)-4-{[(Isopropyl-phenyl-carbamoyl)-methyl]-phenyl-carbamoyl}-4-(3-phenyl-ureido)-butyric acid | Drug Info |
| CCKBR --- CCKAR | Boc-Tyr(So3-)-Met-Gly-Trp-Nle-Asp-psi(CH2NH)-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{[(2R,5S)-2-(1H-indol-3-ylmethyl)-2-methyl-3,13-dioxo-1,4diaza-cyclotridecane-5-carbonyl]-amino}-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{6-(3-Benzyl-ureido)-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CD135 --- Ckit | N-(4-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-ylamino)phenyl)acetamide | Drug Info |
| CD221 --- STK1 | SID137275914 | Drug Info |
| CDK1 --- CDK2 | 4-(2-(4-chloro-5-methoxy-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- CDK2 | GW589933X | Drug Info |
| CDK1 --- GSK3 | 9-Bromo-12-methyl-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK1 --- GSK3 | 6-(4-Chloro-phenyl)-7-isopropyl-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- GSK3 | (E)-3-(6-Oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-benzo[2,3]azepino[4,5-b]indol-2-yl)-acrylonitrile | Drug Info |
| CDK1 --- VEGFR | 5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-N-[2-(dimethylamino)ethyl]pyridine-3-carboxamide | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | N-Benzyl-1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-fluorobenzamide | Drug Info |
| CDK2 --- CDK1 | GW276655X | Drug Info |
| CDK2 --- CDK1 | 2-(3,4-dihydroxy-phenyl)-8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(4-isopropoxy-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-cyclohexylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (trans-4-hydroxycyclohexyl)-amide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-cycloheptylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK4 | 1-(4-{5-Bromo-4-[phenyl-(4,4,4-trifluoro-butyl)-amino]-pyrimidin-2-ylamino}-phenoxy)-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- CDK4 | 4-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-3,5-dimethyl-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | 8-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- CDK4 | N-[4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(4-Oxo-3-propyl-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-iodo-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 4-(4-tert-Butylamino-2-trifluoromethyl-quinazolin-6-yl)-phenol | Drug Info |
| CDK2 --- Cyclin E | (9-Isopropyl-2-pyrrolidin-1-yl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine | Drug Info |
| CDK2 --- Cyclin E | 3-Ethyl-4-methoxy-6-methyl-1-(2,4,6-trichloro-phenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine | Drug Info |
| CDK2 --- Cyclin E | 1-{6-[(Biphenyl-4-ylmethyl)-amino]-9-isopropyl-9H-purin-2-ylamino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | {6-[(Biphenyl-4-ylmethyl)-amino]-2-[bis-(2-hydroxy-ethyl)-amino]-purin-9-yl}-acetic acid tert-butyl ester | Drug Info |
| CDK2 --- GSK3 | 4-(5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylamino)benzenesulfonamide | Drug Info |
| CAII --- CAI | 3-Bromo-4-[(7-chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(Azepane-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | {(2-Hydroxy-phenyl)-[2-((2-hydroxy-phenyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-acetic acid | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(4,5-dihydro-1H-imidazol-2-yl)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 3-(4-(4-bromophenylsulfonyl)phenyl)-4-propyl-1H-1,2,4-triazole-5(4H)-thione | Drug Info |
| COX2 --- 5LOX | 3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-1-(3,4-dimethylphenyl)-5-phenyl-1H-pyrazole | Drug Info |
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