Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| DHFR --- TYMS | 2-(4-{[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-methyl-amino]-methyl}-benzoylamino)-pentanedioic acid | Drug Info |
| CAII --- CAI | 4-(4-trifluoromethylsulfonamidophenylsulfonamido)-1-benzenesulfonamide | Drug Info |
| EGFR --- HER2 | 2-(2-chlorobenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile | Drug Info |
| CAII --- CAI | 4-Chloro-3-sulfamoyl-N-(4-sulfamoyl-phenyl)-benzamide | Drug Info |
| EGFR --- Src | N-Methoxy-3-{2-[3-(2-methoxycarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide | Drug Info |
| CAII --- CAI | [{2-[[(2,3-Dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| EGFR3 --- CSrc | 7-((S)-1-benzyl-2-hydroxyethylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylaminopyrazolo[1,5-a]pyrimidine-3-carboxamide | Drug Info |
| CAII --- CAI | 4-Benzoyl-1-(3-((4-hydroxyphenyl)diazenyl)phenyl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-((4-((2-(methylsulfonyl)ethylamino)methyl)phenyl)ethynyl)pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-(4-Sulfamoyl-benzoylamino)-pentanedioic acid | Drug Info |
| EGFR3 --- HER2 | 2-(2-(4-Bromobenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | {[(2,3-Dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((4-((isopropylamino)methyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| CAII --- CAI | (S)-3-Phenyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| EGFR3 --- HER2 | Tyrosol caffeate | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethyl]-benzamide | Drug Info |
| EGFR3 --- HER2 | 4-(3-Chloro-4-fluoro-phenylamino)-5-[1-[3-methyl-5-(morpholine-4-carbonyl)-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one | Drug Info |
| CAII --- CAI | Sulfamic acid butyl ester | Drug Info |
| EGFR3 --- HER2 | 2-(4-Fluorophenyl)-N-(phenylsulfonyl)acetamide | Drug Info |
| CAII --- CAI | 4-Chloro-3-sulfamoyl-N-(5-sulfamoyl-1H-1lambda*4*-[1,3,4]thiadiazol-2-yl)-benzamide | Drug Info |
| EGFR3 --- HER2 | 7-(4-(4-Fluorobenzylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | ((2-{2-[2-(Carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethoxy]-ethoxy}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-amide | Drug Info |
| CAII --- CAI | 2-Amino-N-{2-[6-(2-hydroxy-ethoxy)-benzothiazole-2-sulfonylamino]-2-oxo-ethyl}-acetamide | Drug Info |
| CAII --- CAI | 2-Methylamino-N-{4-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenesulfamoyl]-phenyl}-acetamide | Drug Info |
| CAII --- CAI | 3-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| CAII --- CAI | 5-(4-Amino-3-bromo-5-iodo-benzenesulfonylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CAII --- CAI | 2-(3-Pentafluorophenyl-ureido)-benzenesulfonamide | Drug Info |
| CAII --- CAI | N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info |
| CAII --- CAIX | 2-Sulfamoyl-benzoic acid methyl ester | Drug Info |
| CAII --- CAXII | 4-hydroxybenzonitrile | Drug Info |
| CALM2 --- Cathepsin B | N-(1-Carbamoyl-2-phenyl-ethyl)-2-[2-(4-dimethylaminomethyl-phenyl)-vinyl]-nicotinamide | Drug Info |
| CALM2 --- Cathepsin B | benzyl 2-(((S)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-4-methylpentanoate | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(3-Imidazol-1-yl-propylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Naphthalen-2-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-2,5-dimethyloxazole-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-3-tert-butyl-N-(1-(cyanomethylamino)-3-(3-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((S)-3-Hydroxy-2-oxo-1-phenethyl-propylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclopentyl-1-oxo-1-((S)-1-(4-(trifluoromethoxy)phenylamino)propan-2-ylamino)propan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | (1-phenethylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 6-(4-chlorobenzyl)-7-(3,3-dimethylbutyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-(1,3,4-thiadiazol-2-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)benzamide | Drug Info |
| Cathepsin K --- MEP | Benzoic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-4-oxo-azetidin-2-yl ester | Drug Info |
| CCKBR --- CCKAR | N-Carboxymethyl-N-[2-(2,4-dichloro-phenyl)-ethyl]-2-(1H-indol-3-ylmethyl)-2-methyl-malonamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(1H-indole-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-thioureido)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(naphthalene-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | (R)-1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide: 0.1C4H10O | Drug Info |
| CCKBR --- CCKAR | 3-{6-[3-(3-Acetyl-phenyl)-ureido]-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
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