Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | CHEMBL402339 | Drug Info |
| CAII --- CAI | Trans-1(R)S,2S(R)-2-(2,3-dibromo-4,5-dimethoxybenzyl)cyclohexanol | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(5-(pyrrolidin-1-yl)pent-1-ynyl)pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-{4-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenesulfamoyl]-phenyl}-acetamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-methoxybenzoic acid | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid piperidin-4-ylmethyl ester | Drug Info |
| CAII --- CAI | 3-(4-sulfamoylphenyl)propanoic acid | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(1-benzyl-1H-indazol-5-ylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide | Drug Info |
| CAII --- CAI | Trifluoro-methanesulfonic acid 2-sulfamoyl-benzothiazol-6-yl ester | Drug Info |
| EGFR3 --- HER2 | 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)-N-(phenylsulfonyl)acetamide | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | CHEMBL197525 | Drug Info |
| CAII --- CAI | ((2-{2-[2-(Carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethoxy]-ethoxy}-ethyl)-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- HER2 | Pentanedioic acid furan-2-ylmethyl ester 4-((E)-2-nitro-vinyl)-phenyl ester | Drug Info |
| CAII --- CAI | N-(2-Chloro-4-sulfamoyl-phenyl)-2,3,4,5,6-pentafluoro-benzenesulfonamide | Drug Info |
| CAII --- CAI | 3-(4-Chloro-3-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| CAII --- CAI | {{2-[Carboxymethyl-(2-{carboxymethyl-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | (R)-4-((3R,5S,7R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-sulfamoyl-phenyl)-amide | Drug Info |
| CAII --- CAI | (5-imino-2-sulfonic acid furane)(4-sulfonamidephenyl)ethanamine | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
| CAII --- CAI | [(2-Hydroxy-phenyl)-(2-{(2-hydroxy-phenyl)-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CAII --- CAIX | 4-(2-((2,4-Diaminopteridin-6-yl)methylamino)ethyl)benzenesulfonamide | Drug Info |
| CAII --- CAIX | Sulfamic acid but-3-ynyl ester | Drug Info |
| CAIX --- CAXII | 7-(2'-fluoroethoxy)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2-naphthalen-1-yl-vinyl)-benzamide | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(Isoquinolin-1-ylmethyl)-aminooxalyl]-propylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | CHEMBL3039860 | Drug Info |
| Cathepsin K --- Cathepsin B | tert-butyl 1-(((S)-1-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl)carbamoyl)cyclohexylcarbamate | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-cyclohexylamino-pyrimidine-5-carboxylic acid {2-[4-(4-methylpiperazin-1-yl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((2S,3S)-2-Benzyloxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 5-Bromo-4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-6-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((S)-1-cyano-2-(4-methoxyphenyl)ethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-(1,3,4-thiadiazol-2-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-3-tert-butyl-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-3-tert-butyl-N-(1-(cyanomethylamino)-3-(3-(5-(methoxymethyl)-1,3,4-oxadiazol-2-yl)phenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-{(S)-3-Cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-propyl}-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | 6-(cyclohexylamino)-9-(2-(4-methylpiperazin-1-yl)ethyl)-9H-purine-2-carbonitrile | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(6-hydroxy-naphthalene-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | [1-[2-(4-Chloro-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | [3H]L-365260 | Drug Info |
| CCKBR --- CCKAR | (2R,3R)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(3,4-dichlorophenyl)butanoic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5S,7R)-7-(4-fluoro-phenyl)-2-oxo-5-phenyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | Boc-Tyr(So3-)-Nle-Gly-Trp-Nle-psi(CH2NH)-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-trifluoromethyl-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-ethanesulfonylaminocarbonyl-phenyl)-ureido]-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-(2-Amino-3-phenyl-propionylamino)-N-(1-{[1-tert-butoxycarbonyl-2-(1H-indol-3-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-thiophen-2-yl-acryloylamino)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CD221 --- JNK1 | 2-(2-(5-(2-(dimethylamino)-N-methylacetamido)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(2-morpholinoethyl)methanesulfonamide | Drug Info |
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