Drug General Information |
Drug ID |
D04NDO
|
Former ID |
DNC010047
|
Drug Name |
4-(2-(2-fluorobenzyloxy)phenyl)piperidine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C18H20FNO
|
Canonical SMILES |
C1CNCCC1C2=CC=CC=C2OCC3=CC=CC=C3F
|
InChI |
1S/C18H20FNO/c19-17-7-3-1-5-15(17)13-21-18-8-4-2-6-16(18)14-9-11-20-12-10-14/h1-8,14,20H,9-13H2
|
InChIKey |
CDVPUDLPRZVZHB-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Dopaminergic synapse
|
Parkinson's disease
|
Cocaine addiction
|
Amphetamine addiction
|
Alcoholismhsa04024:cAMP signaling pathway
|
Neuroactive ligand-receptor interaction
|
Serotonergic synapsehsa04726:Serotonergic synapse
|
NetPath Pathway
|
TCR Signaling Pathway
|
PANTHER Pathway
|
Adrenaline and noradrenaline biosynthesis
|
Parkinson disease
|
Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
|
5HT2 type receptor mediated signaling pathway
|
5HT3 type receptor mediated signaling pathway
|
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
Pathway Interaction Database
|
Alpha-synuclein signaling
|
Reactome
|
Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
|
G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
|
WikiPathways
|
Monoamine Transport
|
NRF2 pathway
|
Dopaminergic Neurogenesis
|
Parkinsons Disease Pathway
|
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
|
Neurotransmitter Clearance In The Synaptic CleftWP722:Serotonin HTR1 Group and FOS Pathway
|
SIDS Susceptibility Pathways
|
Monoamine GPCRs
|
GPCRs, Class A Rhodopsin-like
|
GPCR ligand binding
|
GPCR downstream signalingWP727:Monoamine Transport
|
Synaptic Vesicle Pathway
|
Serotonin Transporter ActivityWP727:Monoamine Transport
|
References |
REF 1 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. Epub 2009 Oct 12.Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |